Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered modified nucleosides: ct6A, ms2ct6A, ges2U

2017/25/B/ST5/00971

Keywords:

tRNA modified nucleosides oligoribonucleotide synthesis geranylated 2-thiouridines modified adenosines ct6A ms2ct6A RNA structure biomolecular NMR spectroscopy,

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Łódzka, Wydział Chemiczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Sochacka 

Number of co-investigators in the project: 9

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 390 200 PLN

Project start date (Y-m-d): 2018-02-21

Project end date (Y-m-d): 2022-02-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw HPLC (340 000 PLN)
  2. pompa próżniowa (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Computational and NMR studies of RNA duplexes with an internal pseudouridine-adenosine base pair
    Authors:
    Indrajit Deb, Łukasz Popenda, Joanna Sarzyńska, Magdalena Małgowska, Ansuman Lahiri, Zofia Gdaniec, Ryszard Kierzek
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 16278), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-52637-0 - link to the publication
  2. Chemical synthesis of oligoribonucleotide (ASL of tRNALys T.brucei) containing a recently discovered cyclic form of 2-methylthio-N6-threonylcarbamoyladenosine (ms2ct6A)
    Authors:
    Debiec K, Matuszewski M, Podskoczyj K, Leszczynska G, Sochacka E.
    Academic press:
    Chemistry, A European Journal (rok: 2019, tom: 25, strony: 13309-13317), Wydawca: Wiley – VCH
    Status:
    Published
    DOI:
    10.1002/chem.201902411 - link to the publication
  3. Nano LC-MS using capillary columns enables accurate quantification of modified ribonucleosides at low femtomol levels
    Authors:
    L. P. Sarin, S. D. Kienast, J. Leufken, R. L. Ross, A. Dziergowska, K. Debiec, E. Sochacka, P. A. Limbach,
    Academic press:
    RNA (rok: 2018, tom: 24, strony: 1403-1417), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.065482.117 - link to the publication
  4. New efficient synthesis of tRNA related adenosines bearing the hydantoin ring (ct6A, ms2ct6A) by intramolecular cyclization of N6-Boc-α-aminoacyl)adenosine derivatives-
    Authors:
    Katarzyna Frankowska, Elżbieta Sochacka
    Academic press:
    ChemBioChem (rok: 2022, tom: 23, strony: e2002100655), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/cbic.202100655 - link to the publication
  5. Synthesis of nucleobase-modified RNA oligonucleotides by post-synthetic approach
    Authors:
    Karolina Bartosik, Katarzyna Debiec, Anna Czarnecka, Elzbieta Sochacka, grazyna Leszczynska
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3344), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25153344 - link to the publication
  6. Efficient access to 3'-O-phosphoramidite derivatives of tRNA related N6-threonylcarbamoyladenosine (t6A) and 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)
    Authors:
    Katarzyna Debiec, Elzbieta Sochacka
    Academic press:
    RSC Advances (rok: 2021, tom: 11, strony: 1992-1999), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0ra09803e - link to the publication
  7. Thermodynamic and structural contributions of the 6-thioguanosine residue to helical properties of RNA
    Authors:
    Michał Gładysz, Witold Andrałojć , Tomasz Czapik , Zofia Gdaniec, Ryszard Kierzek
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 4385), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-40715-2 - link to the publication

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