Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Application of targeted metabolomic approach in quantitative prospective analysis of nucleosides profiles alterations before and after bladder cancer resection

2018/29/N/NZ7/02299

Keywords:

bladder cancer modified nucleosides metabolomics mass spectrometry

Descriptors:

  • NZ5_5: Diagnostics in human diseases
  • NZ2_4: Metabolomics
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmacutyczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Małgorzata Artymowicz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 138 280 PLN

Project start date (Y-m-d): 2019-02-25

Project end date (Y-m-d): 2023-02-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer osobisty (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. Development the procedure of modified nucleosides and deoxynucleosides extraction for targeted metabolomics analysis with the use of DoE approach
    Authors:
    Małgorzata Artymowicz, Szymon Macioszek, Julia Jacyna, Joanna Dawidowska, Wiktoria Struck-Lewicka, Michał J. Markuszewski, Danuta Siluk
    Academic press:
    Sustainable Chemistry and Pharmacy (rok: 2021, tom: 21, strony: 100439), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scp.2021.100439 - link to the publication
  2. Targeted quantitative metabolomics with a linear mixed-effect model for analysis of urinary nucleosides and deoxynucleosides from bladder cancer patients before and after tumor resection
    Authors:
    Małgorzata Artymowicz, Wiktoria Struck-Lewicka, Paweł Wiczling, Marcin Markuszewski, Michał J. Markuszewski, Danuta Siluk
    Academic press:
    Analytical and Bioanalytical Chemistry (rok: 2023, tom: 415, strony: 17), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-023-04826-0 - link to the publication
  1. Artymowicz M, Macioszek Sz, Wykorzystanie metod planowania eksperymentu do optymalizacji procedury ekstrakcji modyfikowanych nukleozydów i deoksynukleozydów w celowanej analizie metabolomicznej
    Authors:
    Małgorzata Artymowicz, Szymon Macioszek, Julia Jacyna, Joanna Dawidowska, Gracjana Stachewicz, Wiktoria Struck-Lewicka, Michał J. Markuszewski, Danuta Siluk
    Conference:
    XXVI Konferencja Naukowa Wydziału Farmaceutycznego Gdańskiego Uniwersytetu Medycznego (rok: 2021, ), Wydawca: Organizator konferencji
    Data:
    konferencja 28-29.01.2021
    Status:
    Published
  2. Method development and validation for targeted analysis of modified nucleosides and deoxynucleosides in urine samples obtained from patients diagnosed with bladder cancer
    Authors:
    Małgorzata Artymowicz, Wiktoria Struck-Lewicka, Danuta Siluk, Marcin Markuszewski, Marcin Matuszewski, Michał J. Markuszewski
    Conference:
    ACCORD 2022: Interdisciplinary Conference on Drug Sciences (rok: 2022, ), Wydawca: Organizator konferencji
    Data:
    konferencja 26-28.05.2022
    Status:
    Published
  3. Method development for determination of modified nucleosides and deoxynucleosides in urine and plasma samples
    Authors:
    Małgorzata Patejko, Wiktoria Struck-Lewicka, Danuta Siluk, Michał J. Markuszewski
    Conference:
    Metabolomics 2019: 15th Annual Conference of the Metabolomics Society (rok: 2019, ), Wydawca: Organizator konferencji
    Data:
    konferencja 23-27.07.2019
    Status:
    Published

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