Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Adaptations of cardiac myocyte energy metabolism in atherosclerosis - implications for pathology and therapeutic strategies

2016/23/B/NZ4/03877

Keywords:

Cardiac energy metabolism Nucleotides Mitochondria Atherosclerosis Ischemia

Descriptors:

  • NZ4_11: Metabolism
  • NZ5_3: Pathogenesis of human diseases
  • NZ1_2: Biochemistry

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ryszard Smoleński 

Number of co-investigators in the project: 7

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 997 250 PLN

Project start date (Y-m-d): 2017-08-03

Project end date (Y-m-d): 2022-08-02

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System klatek indywidualnie wentylowanych z wyposażeniem (110 000 PLN)
  2. Analizator przepływów metabolicznych Seahorse.

Information in the final report

  • Publication in academic press/journals (16)
  1. Cardiac Mitochondria Dysfunction in Dyslipidemic Mice
    Authors:
    Alicja Braczko 1,† , Barbara Kutryb-Zajac 1,*,† , Agata Jedrzejewska 1 , Oliwia Krol 1 , Paulina Mierzejewska 1, Magdalena Zabielska-Kaczorowska 1,2, Ewa M. Slominska 1 and Ryszard T. Smolenski
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 11488), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231911488 - link to the publication
  2. Enhanced Muscle Strength in Dyslipidemic Mice and Its Relation to Increased Capacity for Fatty Acid Oxidation
    Authors:
    Marta Tomczyk 1,*, Alicja Braczko 1, Patrycja Jablonska 1, Adriana Mika 2, Kamil Przyborowski 3, Agata Jedrzejewska 1, Oliwia Krol 1, Filip Kus 1,4,, Tomasz Sledzinski 2, Stefan Chlopicki 3,5, Ewa M. Slominska 1 and Ryszard T. Smolenski 1,*
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 222, strony: 2251), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222212251 - link to the publication
  3. The effects of pro- and anti-atherosclerotic factors on intracellular nucleotide concentration in murine endothelial cells
    Authors:
    Barbara Kutryb-Zajaca, Patrycja Koszalkab, Ewa M. Slominskaa, and Ryszard T. Smolenskia
    Academic press:
    NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS (rok: 2018, tom: 37, strony: 645-652), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2018.1498513 - link to the publication
  4. The new insight into extracellular NAD+ degradation-the contribution of CD38 and CD73 in calcific aortic valve disease
    Authors:
    Patrycja Jablonska, Barbara Kutryb-Zajac, Paulina Mierzejewska, Agnieszka Jasztal, Barbara Bocian, Romuald Lango, Jan Rogowski, Stefan Chlopicki, Ryszard T. Smolenski, Ewa M. Slominska
    Academic press:
    Journal of Cellular and Molecular Med.icine (rok: 2021, tom: 25, strony: 5884–5898), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jcmm.15912 - link to the publication
  5. Inhibition of LPS-stimulated ecto-adenosine deaminase attenuates endothelial cell activation
    Authors:
    Barbara Kutryb-Zajac, Paulina Mierzejewska, Elzbieta Sucajtys-Szulc, Alicja Bulinska, Magdalena A. Zabielska, Patrycja Jablonska, Marcin Serocki, Patrycja Koszalka, Ryszard Milczarek, Agnieszka Jasztal, Rafal Bartoszewski, Stefan Chlopicki, Ewa M. Slominska, Ryszard T. Smolenski
    Academic press:
    Journal of Molecular and Cellular Cardiology (rok: 2019, tom: 128, strony: 62-76), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.yjmcc.2019.01.004 - link to the publication
  6. Multi‑omic signatures of atherogenic dyslipidaemia: pre‑clinical target identification and validation in humans
    Authors:
    Mariola Olkowicz, Izabela Czyzynska‑Cichon, Natalia Szupryczynska, Renata B. Kostogrys, Zdzislaw Kochan, Janusz Debski, Michal Dadlez, Stefan Chlopicki and Ryszard T. Smolenski
    Academic press:
    Journal of Translational Medicine (rok: 2021, tom: 19, strony: 6), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12967-020-02663-8 - link to the publication
  7. Enhanced cardiac hypoxic injury in atherogenic dyslipidaemia results from alterations in the energy metabolism pattern
    Authors:
    Mariola Olkowicz, Marta Tomczyk, Janusz Debski, Urszula Tyrankiewicz, Kamil Przyborowski, Tomasz Borkowski, Magdalena Zabielska-Kaczorowska, Natalia Szupryczynska, Zdzislaw Kochan, Marta Smeda, Michal Dadlez, Stefan Chlopicki, Ryszard T. Smolenski
    Academic press:
    Metabolism Clinical and Experimental (rok: 2021, tom: 114, strony: 154400), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.metabol.2020.154400 - link to the publication
  8. High Throughput Procedure for Comparative Analysis of In Vivo Cardiac Glucose or Amino Acids Use in Cardiovascular Pathologies and Pharmacological Treatments
    Authors:
    Marta Tomczyk, Mariola Olkowicz, Ewa M. Slominska and Ryszard T. Smolenski
    Academic press:
    Metabolites (rok: 2021, tom: 11, strony: 497), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  9. Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease
    Authors:
    Filip Kus 1,2 , Ryszard T. Smolenski 2,* and Marta Tomczyk
    Academic press:
    Biomedicines (rok: 2022, tom: 10, strony: 913), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines10040913 - link to the publication
  10. Metabolic Pattern of Systemic Sclerosis: Association of Changes in Plasma Concentrations of Amino Acid-Related Compounds With Disease Presentation
    Authors:
    Zaneta Smolenska, Magdalena Zabielska-Kaczorowska, Anna Wojteczek, Barbara Kutryb-Zajac and Zbigniew Zdrojewski
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2020, tom: 7, strony: 585161), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2020.585161 - link to the publication
  11. Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside
    Authors:
    Łukasz Mateuszuk, Roberto Campagna, Barbara Kutryb-Zając, Kamil Kuś, Ewa M. Słominska, Ryszard T. Smolenski, Stefan Chlopicki
    Academic press:
    Biochemical Pharmacology (rok: 2020, tom: 178, strony: 114019), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2020.114019 - link to the publication
  12. Rosiglitazone Ameliorates Cardiac and SkeletalMuscle Dysfunction by Correction of Energetics in Huntington's Disease
    Authors:
    Marta Tomczyk 1,2,* , Alicja Braczko 1 , Paulina Mierzejewska 1, Magdalena Podlacha 2, Oliwia Krol 1 , Patrycja Jablonska 1, Agata Jedrzejewska 1 , Karolina Pierzynowska 1,2, Grzegorz Wegrzyn 2 , Ewa M. Slominska 1 and Ryszard T. Smolenski
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 2662), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11172662 - link to the publication
  13. The effect of trehalose on intracellular and extracellular nucleotide metabolism. A pilot study
    Authors:
    Mikolaj Opielka , Bartosz Sobocki , Paulina Mierzejewska, and Ryszard T. Smolenski
    Academic press:
    NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS (rok: 2020, tom: 39, strony: 1400–1409), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2020.1772492 - link to the publication
  14. Effect of estradiol on enzymes of vascular extracellular nucleotide metabolism
    Authors:
    Areta Hebanowska1 & Paulina Mierzejewska1 & Alicja Braczko1
    Academic press:
    Hormones (rok: 2021, tom: 20, strony: 111-117), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s42000-020-00242-6 - link to the publication
  15. Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases
    Authors:
    Barbara Kutryb-Zajac Paulina Mierzejewska, Ewa M. Slominska and Ryszard T. Smolenski
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4562), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204652 - link to the publication
  16. Vascular extracellular adenosine metabolism in mice correlates with susceptibility to atherosclerosis
    Authors:
    Barbara Kutryb-Zajac, Alicja Bulinska, Magdalena A. Zabielska, Paulina Mierzejewska, Ewa M. Slominska, and Ryszard T. Smolenski
    Academic press:
    NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS (rok: 2018, tom: 37, strony: 653-662), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2018.1489051 - link to the publication

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