Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pro-nucleotides based on mRNA cap structure - synthesis, biological and biophysical evaluation

2016/21/D/ST5/01654

Keywords:

cap structure mRNA lyposomes pro-nucleotides pro-drugs amidophosphates amidodiphospates phosphotriesters

Descriptors:

  • ST5_16:
  • ST5_23:
  • NZ1_1: Molecular biology

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Karolina Piecyk 

Number of co-investigators in the project: 6

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 476 450 PLN

Project start date (Y-m-d): 2017-01-27

Project end date (Y-m-d): 2021-07-26

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer.
  2. Liofilizator (70 000 PLN)
  3. Laptop z projektorem multimedialnym (8 954 PLN)
  4. Tablet.
  5. Monitory.
  6. Pompa olejowa (15 000 PLN)
  7. Spektrofotometr (35 000 PLN)
  8. Waga analityczna (2 szt.) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Modified ARCA analogs providing enhanced translational properties of capped mRNAs.
    Authors:
    Kocmik I, Piecyk K, Rudzinska M, Niedzwiecka A, Darzynkiewicz E, Grzela R, Jankowska-Anyszka M
    Academic press:
    Cell Cycle (rok: 2018, tom: 17, strony: 1624-1636), Wydawca: Taylor
    Status:
    Published
    DOI:
    10.1080/15384101.2018.1486164. - link to the publication
  2. Effect of HIV-1 TAT Peptide Fusion on 5′ mRNA Cap Analogs Cell Membrane Permeability and Translation Inhibition
    Authors:
    Karolina Piecyk Karolina Piecyk Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland More by Karolina Piecyk , Paulina Pietrow, Thomas Arnold, Remigiusz Worch, Nadejda L. Korneeva, and Marzena Jankowska-Anyszka
    Academic press:
    Bioconjugate Chemistry (rok: 2020, tom: 31, strony: 1156-1166), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.0c00080 - link to the publication
  3. "Synthesis of the first double-functionalized dinucleotide mRNA cap analogue for its specific labeling"
    Authors:
    Piecyk K., Krynska P., Kaluzna J., Jankowska-Anyszka M.,
    Academic press:
    Tetrahedron Letters (rok: 2017, tom: 58, strony: 3037-3040), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetlet.2017.06.060 - link to the publication
  4. Isoxazole-containing 5′ mRNA cap analogues as inhibitors of the translation initiation process
    Authors:
    Karolina Piecyk, Maciej Lukaszewicz, Karol Kamel, Maria Janowska, Paulina Pietrow, Sebastian Kmiecik, Marzena Jankowska-Anyszka
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 96, strony: 45298), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103583 - link to the publication
  5. Application of phosphoramidate ProTide technology for the synthesis of 5' mRNA cap analogs modified within exocyclic amine group
    Authors:
    Izabela Siekierska, Maciej Lukaszewicz, Remigiusz Worch, Marzena Jankowska-Anyszka, Karolina Piecyka
    Academic press:
    ChemMedChem , Wydawca: European Chemical Societies Publishing
    Status:
    Submitted
    DOI:
    brak - link to the publication

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