Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Regulation of Expression of Ecto-5'-Nucleotidase - Changes in Pathology and Therapeutic Potential

2011/01/B/NZ4/03719

Keywords:

Extrcellular enzymes Ecto-5'-nucleotidase Adenosine Nucleotides Vascular disease Valve calcification Xanotransplantation

Descriptors:

  • NZ1_2: Biochemistry

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ryszard Smoleński 

Number of co-investigators in the project: 6

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 597 400 PLN

Project start date (Y-m-d): 2011-12-15

Project end date (Y-m-d): 2016-11-14

Project duration:: 59 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Głowica/źródło jonów do detektora masowego TSQ VANTAGE (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  1. EXTRACELLULAR ADENINE NUCLEOTIDE CATABOLISM IN HEART VALVES
    Authors:
    Marta Toczek, Barbara Kutryb-Zając, Małgorzata Kapczyńska, Marcin Lipiński, Ewa M. Słomińska, Ryszard T. Smoleński
    Academic press:
    Nucleosides Nucleotides Nucleic Acids (rok: 2014, tom: 33, strony: 329-332), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2014.880479 - link to the publication
  2. Changes in cardiac nucleotide metabolism in Huntington's disease
    Authors:
    Marta Toczek, Barbara Kutryb-Zajac, Paulina Zukowska, Ewa M. Slominska, Mark Isalan, Michal Mielcarek & Ryszard T. Smolenski
    Academic press:
    Nucleosides, Nucleotides and Nucleic Acids (rok: 2016, tom: 35, strony: 707-712), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2016.1154969 - link to the publication
  3. EXTRACELLULAR NUCLEOTIDE CATABOLISM IN AORTOILIAC BIFURCATION OF ATHEROSCLEROTIC APOE/LDLR DOUBLE KNOCK OUT MICE
    Authors:
    Barbara Kutryb-Zając, Paulina Żukowska, Marta Toczek, Magdalena Zabielska, Marcin Lipiński, Iwona Rybakowska, Stefan Chłopicki, Ewa M. Słomińska, Ryszard T. Smoleński.
    Academic press:
    Nucleosides, Nucleotides and Nucleic Acids (rok: 2014, tom: 33, strony: 323-328), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2014.880478 - link to the publication
  4. Polymorphism in exon 6 of the human NT5E gene is associated with aortic valve calcification
    Authors:
    Zdzislaw Kochan, Joanna Karbowska, Patrycja Gogga, Barbara Kutryb-Zajac, Ewa M. Slominska & Ryszard T. Smolenski
    Academic press:
    Nucleosides, Nucleotides and Nucleic Acids (rok: 2016, tom: 35, strony: 726-731), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2016.1180393 - link to the publication
  5. IMMUNOHISTOCHEMICAL ANALYSIS OF ENTPD1 (CD39) AND E5NT (CD73) EXPRESSION IN PIG AORTIC VALVES
    Authors:
    Ewa Kaniewska, Alicja Sielicka, Padmini Sarathchandra, Iwona Pelikant-Małecka, Mariola Olkowicz, Ewa M. Słomińska, Adrian H. Chester, Magdi H. Yacoub, Ryszad T. Smoleński
    Academic press:
    Nucleosides Nucleotides Nucleic Acids (rok: 2014, tom: 33, strony: 305-312), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2014.885985 - link to the publication
  6. Oxidized low-density lipoproteins enhance expression and activity of CD39 and CD73 in the human aortic valve endothelium
    Authors:
    Ewa Kaniewska-Bednarczuk, Michał Mielcarek, Adrian H. Chester, Ewa M. Slominska, Magdi H Yacoub & Ryszard T. Smolenski
    Academic press:
    Nucleosides, Nucleotides and Nucleic Acids (rok: 2016, tom: 35, strony: 713-719), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2016.1163377 - link to the publication
  7. An impaired metabolism of nucleotides underpins a novel mechanismof cardiac remodeling leading to Huntington's disease related cardiomyopathy
    Authors:
    Marta Toczek, Daniel Zielonka, Paulina Zukowska, Jerzy T. Marcinkowski, Ewa Slominska, Mark Isalan, Ryszard T. Smolenski, Michal Mielcarek
    Academic press:
    Biochimica et Biophysica Acta (rok: 2016, tom: 1862, strony: 2147-2157), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2016.08.019 - link to the publication
  8. EFFECT OF NITROSATIVE STRESS ON EXTRACELLULAR NUCLEOTIDE METABOLISM IN ENDOTHELIAL CELLS
    Authors:
    A. Sielicka, I. Pelikant-Malecka, E. Kaniewska, M. Olkowicz, Z. Pankrac, M. Swiatkowska-Freund, K. Preis, M. Gorska, E. M. Slominska, R. T. Smolenski
    Academic press:
    Nucleosides Nucleotides Nucleic Acids (rok: 2014, tom: 33, strony: 342-346), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2014.898069 - link to the publication
  9. Inhibition of AMP deaminase as therapeutic target in cardiovascular pathology
    Authors:
    Zabielska MA, Borkowski T, Slominska EM, Smolenski RT
    Academic press:
    Pharmacol Rep (rok: 2015, tom: 67, strony: 682-8), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.04.007. - link to the publication
  10. Nucleotide Catabolism on the Surface of Aortic Valve Xenografts; Effects of Different Decellularization Strategies
    Authors:
    Kutryb-Zajac B, Yuen AH, Khalpey Z, Zukowska P, Slominska EM, Taylor PM, Goldstein S, Heacox AE, Lavitrano M, Chester AH, Yacoub MH, Smolenski RT
    Academic press:
    J Cardiovasc Transl Res (rok: 2016, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  11. The role of ecto-5'-nucleotidase in endothelial dysfunction and vascular pathologies
    Authors:
    Zukowska P, Kutryb-Zajac B, Toczek M, Smolenski RT, Slominska EM.
    Academic press:
    Pharmacol Rep (rok: 2015, tom: 67, strony: 675-81), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.05.002 - link to the publication

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