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Application of LCMS to quantitative analysis of composition of in vitro transcribed RNAs containing chemically modified adenine nucleotides

2016/23/N/ST4/03186

Keywords:

mass spectrometry liquid chromatography nucleotides mRNA ATP and AMP analogues

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_6: Instrumental methods in chemistry
  • NZ1_1: Molecular biology

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Dominika Strzelecka 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 99 960 PLN

Project start date (Y-m-d): 2017-07-27

Project end date (Y-m-d): 2019-07-26

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions
    Authors:
    Przemysław Wanat, Renata Kasprzyk, Michał Kopciał, Paweł J. Sikorski, Dominika Strzelecka, Jacek Jemielity, Joanna Kowalska
    Academic press:
    Chemical Communications (rok: 2018, tom: 54, strony: 9773-9776), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8cc04968h - link to the publication
  2. Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression
    Authors:
    Dominika Strzelecka, Miroslaw Smietanski, Pawel J. Sikorski, Marcin Warminski, Joanna Kowalska, Jacek Jemielity
    Academic press:
    RNA (rok: 2020, tom: in press, strony: in press), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.077099.120 - link to the publication
  1. Analysis of thiophosphate RNA modification using LC-MS
    Authors:
    D. Strzelecka, M. Smietanski, M. Warminski, P. Sikorski, J. Jemielity, J.Kowalska
    Conference:
    6th Conference of Polish Mass Spectrometry Society (rok: 2018, ), Wydawca: Institute of Organic Chemistry, Polish Academy of Sciences
    Data:
    konferencja 23-26.04.2018
    Status:
    Published
  2. DEVELOPMENT OF THE LC-MS METHOD FOR THE ANALYSIS AND CHARACTERIZATION CHEMICALLY MODIFIED RNA
    Authors:
    D. Strzelecka, M. Smietanski, M. Warminski, P. Sikorski, J. Jemielity, J.Kowalska
    Conference:
    22nd INTERNATIONAL MASS SPECTROMETRY CONFERENCE (IMSC) (rok: 2018, ), Wydawca: International Mass Spectrometry Foundation
    Data:
    konferencja 26-31.08.2018
    Status:
    Published
  3. Development of the LC-MS method for the analysis and characterization chemically modified RNA with therapeutic potential
    Authors:
    D. Strzelecka, M. Smietanski, M. Warminski, P. Sikorski, J. Jemielity, J.Kowalska
    Conference:
    Young Scientist Symposium 11th Edition (rok: 2018, ), Wydawca: Institut Europeen de Chimie et Biologie
    Data:
    konferencja 24-25.05.2018
    Status:
    Published
  4. LC-MS/MS-based analysis of mRNA 5' cap metabolism and its analogs in cytoplasmic extracts of mammalian cells
    Authors:
    D. Strzelecka, M. Bednarczyk, K. Kaczmarska, P. Sikorski, J. Jemielity, J. Kowalska
    Conference:
    Young Scientist Symposium 12th Edition (rok: 2019, ), Wydawca: Institut Europeen de Chimie et Biologie
    Data:
    konferencja 23-24.05.2019
    Status:
    Published

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