Projects funded by the NCN


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170 projects found matching your search criteria :

  1. The role of sirtuins and AMPK protein kinase in insulin resistance of podocytes

    Call: OPUS 3 , Panel: NZ5

    Principal investigator: dr Dorota Rogacka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  2. Czy hiperaktywacja kinazy mTOR prowadzi do zaburzeń różnicowania komórek nerwowych?

    Call: FUGA 1 , Panel: NZ3

    Principal investigator: dr Bartosz Tarkowski

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  3. An attempt to elucidate the role of clusterin and lipid rafts in Alzheimer's disease etiology.

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: prof. Arkadiusz Orzechowski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  4. PIM kinases as rational therapeutic targets in lymphoid malignancies.

    Call: OPUS 2 , Panel: NZ4

    Principal investigator: dr hab. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

  5. The role of SnRK2 kinases in plant response to environmental stresses. The interplay between SnRK2 kinases, PP2C phospha...

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: prof. Grażyna Dobrowolska

    Instytut Biochemii i Biofizyki PAN

  6. Investigation of histidine phosphorylation in thymidylate synthase and searching for causative protein kinase

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: dr hab. Joanna Cieśla

    POLITECHNIKA WARSZAWSKA

  7. Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Artur Świerczek

    Uniwersytet Jagielloński, Collegium Medicum

  8. Zn2+-dependent competition between CD4 and CD8α coreceprtor for Lck tyrosine kinase

    Call: SONATA 19 , Panel: NZ1

    Principal investigator: dr Anna Kocyła

    Uniwersytet Wrocławski, Wydział Biotechnologii

  9. Deciphering the importance of the intracellular FGFR1 module for cell fate

    Call: OPUS 26 , Panel: NZ1

    Principal investigator: dr hab. Małgorzata Zakrzewska

    Uniwersytet Wrocławski, Wydział Biotechnologii

  10. First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: prof. Jadwiga Handzlik

    Uniwersytet Jagielloński, Collegium Medicum

  11. Regulation of clathrin-dependent endocytosis by mTOR kinase in neuronal development

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: prof. Jacek Jaworski

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  12. Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Magdalena Wujak

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  13. Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

    Call: OPUS 26 , Panel: NZ5

    Principal investigator: dr Tomasz Prajsnar

    Uniwersytet Jagielloński, Wydział Biologii

  14. Exploring kinase hyperactivation as an innovative approach for chemo-immunotherapy for B cell acute lymphoblastic leukem...

    Call: PRELUDIUM BIS 5 , Panel: NZ7

    Principal investigator: dr hab. Małgorzata Firczuk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  15. Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

    Call: OPUS 25 , Panel: NZ5

    Principal investigator: prof. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

  16. Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Krzysztof Domka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  17. Regulacja procesu deoksyhypuzynacji przez kinazy białkowe

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Paweł Kochanowski

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  18. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  19. INVADOPODIA IN AXL-DRIVEN CANCER INVASION AND DRUG RESISTANCE

    Call: OPUS 25 , Panel: NZ3

    Principal investigator: dr Daria Zdżalik-Bielecka

    Uniwersytet Warszawski, Wydział Biologii

  20. Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Marika Frańczak

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  21. The potassium puzzle: unraveling the connection between the potassium channel and lipid kinases in kidney functioning

    Call: OPUS 25 , Panel: NZ1

    Principal investigator: dr hab. Piotr Koprowski

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  22. The effect of PKC epsilon modification on autophagy in cancer cells.

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: prof. Maria Rybczyńska

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

  23. Dissecting the regulatory interplay between proteases and protein kinases in acute lymphoblastic leukemia using mass cyt...

    Call: OPUS 24 , Panel: NZ5

    Principal investigator: dr hab. Marcin Poręba

    Politechnika Wrocławska

  24. Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

    Call: POLONEZ BIS 3 , Panel: NZ7

    Principal investigator: dr hab. Aneta Radziwon-Balicka

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  25. A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

    Call: OPUS 24 (LAP) , Panel: NZ7

    Principal investigator: dr hab. Anna Więckowska

    Uniwersytet Jagielloński, Collegium Medicum

  26. Thermodynamic contribution of halogen bonds in protein-ligand systems. Design, synthesis, and thermodynamic studies of m...

    Call: PRELUDIUM 21 , Panel: ST4

    Principal investigator: Sławomir Kasperowicz

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  27. Smart tissue engineering to change the paradigm of diabetes treatment

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Anna Czarna

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  28. Unraveling mechanisms and physiological outcome of lipid-evoked regulation of proteostasis in the intestine.

    Call: OPUS 23 , Panel: NZ4

    Principal investigator: dr hab. Grzegorz Sumara

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  29. The SnRK2 kinases as key proteins in seeds biology- unraveling new molecular mechanisms determining seed germination abi...

    Call: OPUS 23 , Panel: NZ3

    Principal investigator: dr Anna Kulik

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  30. Analysis of molecular background of clear cell renal cell carcinoma and role of MCPIP1 in tomorigenesis

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: prof. Jolanta Jura

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  31. Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr Maciej Szydłowski

    Instytut Hematologii i Transfuzjologii

  32. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  33. Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

    Call: PRELUDIUM BIS 3 , Panel: NZ5

    Principal investigator: prof. Ireneusz Majsterek

    Uniwersytet Medyczny w Łodzi

  34. New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Anna Florczak

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  35. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

    Call: OPUS 22 (LAP) , Panel: NZ7

    Principal investigator: prof. Kinga Sałat

    Uniwersytet Jagielloński, Collegium Medicum

  36. Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

    Call: SONATA BIS 11 , Panel: NZ5

    Principal investigator: dr Anna Marusiak

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  37. RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Mikołaj Czajkowski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  38. Expression, regulation and function of super-enhancer non-coding RNAs in Diffuse Large B-Cell Lymphoma (DLBCL)

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: Sonia Dębek

    Instytut Hematologii i Transfuzjologii

  39. Investigating the role of the focal adhesion kinase and its related signaling pathways in glucocorticoid- and stress-ind...

    Call: PRELUDIUM 20 , Panel: NZ4

    Principal investigator: Michał Wilczkowski

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  40. MLK4 signaling in DNA damage response and cancer therapy

    Call: PRELUDIUM 20 , Panel: NZ3

    Principal investigator: Dawid Mehlich

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  41. AXL receptor signaling in cancer cell growth and drug resistance

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: prof. Marta Miączyńska

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  42. Iron chelators as tyrosine kinase inhibitors - a new strategy for the treatment of glioblastoma multiforme

    Call: PRELUDIUM BIS 2 , Panel: NZ5

    Principal investigator: dr hab. Anna Mrozek-Wilczkiewicz

    Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

  43. Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  44. A novel approach based on the optimized multidrug combination for glioblastoma treatment.

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: dr Małgorzata Kucińska

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  45. FAST interactions in cell death regulation

    Call: PRELUDIUM 19 , Panel: NZ1

    Principal investigator: Daria Dawidziak

    Uniwersytet Warszawski, Wydział Chemii

  46. OMENTIN1 as a new regulator of female reproduction - expression and role in the pituitary - ovary axis. Study on swine m...

    Call: OPUS 19 , Panel: NZ9

    Principal investigator: dr hab. Agnieszka Rak

    Uniwersytet Jagielloński, Wydział Biologii

  47. Towards innovative strategy for treatment of Alzheimer's Disease via dual inhibition of receptor 5-HT6 and kinase CDK5.

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Sylwia Sudoł

    Uniwersytet Jagielloński, Collegium Medicum

  48. The proangiogenic functions of PIM kinases in plasma cell myeloma

    Call: ETIUDA 8 , Panel: NZ5

    Principal investigator: Filip Garbicz

    Instytut Hematologii i Transfuzjologii

  49. New insights into multifaceted targeted therapy for treatment of glioblastoma multiforme.

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: dr Katarzyna Malarz

    Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

  50. Determination of the role of present in extracelluar space integrin-linked kinase (ILK) in adhesion, migration/invasion ...

    Call: PRELUDIUM BIS 1 , Panel: NZ3

    Principal investigator: dr hab. Antonina Mazur

    Uniwersytet Wrocławski, Wydział Biotechnologii