Projects funded by the NCN

Information on the principal investigator and host institution

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Estrogen dependent signal transduction associated with PELP1 protein in male reproductive system

2016/23/D/NZ5/02604

Keywords:

estrogen receptors - ESR1 ESR2 male infertility Proline Glutamic Acid Leucine Rich Protein 1 - PELP1 signal transduction SRC kinase

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ4_6: Endocrinology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Nauk o Zdrowiu

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Izabela Skibińska 

Number of co-investigators in the project: 3

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 239 998 PLN

Project start date (Y-m-d): 2017-07-14

Project end date (Y-m-d): 2022-07-13

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Increased expression of PELP1 in human sperm is correlated with decreased semen quality.
    Authors:
    Skibińska Izabela, Andrusiewicz Mirosław, Soin Michał, Jendraszak Magdalena, Urbaniak Paulina, Jędrzejczak Piotr, Kotwicka Małgorzata
    Academic press:
    Asian Journal of Andrology (rok: 2018, tom: n/a, strony: 425-431), Wydawca: Shanghai Materia Medica, Shanghai Jiao Tong University
    Status:
    Published
    DOI:
    10.4103/aja.aja_11_18. - link to the publication
  2. Expression of ESRs, PELP1, and SRC in human spermatozoa and their associations with semen quality
    Authors:
    Skibińska, Izabela; Andrusiewicz, Mirosław; Jendraszak, Magdalena; Żbikowska, Aleksandra; Jędrzejczak, Piotr; Kotwicka, Małgorzata
    Academic press:
    Human Cell (rok: 2022, tom: 36(2), strony: 554-567), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13577-022-00847-6 - link to the publication
  3. PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis
    Authors:
    Skibińska, Izabela; Andrusiewicz, Mirosław; Jendraszak, Magdalena; Żbikowska, Aleksandra; Żaba, Czesław; Kotwicka, Małgorzata
    Academic press:
    Acta Biochimica Polonica , Wydawca: Polish Biochemical Society
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication

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