Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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DEVELOPMENT OF NEW CLASS PHOTOACTIVATED ANTICANCER-ANTIFUNGAL COMPOUNDS: CONJUGATES OF GOLD NANOPARTICLE-SUPPORTED QUINONE METHIDES-ANTICANCER DRUGS, FOR MULTIMODAL TREATMENT OF URINARY BLADDER TUMORS

2019/33/B/NZ7/01608

Keywords:

QUINONE METHIDE QUINONE OXIMES SYNTHETIC ELECTROCHEMISTRY ANTIFUNGAL ANTIBIOTIC ANTICANCER PROTEIN KINASE BIOISOSTERISM DRUG CANDIDATES PHOTOSENSIBILISATION GOLD NANOPARTICLES MULTIMODAL DRUGS

Descriptors:

  • ST4_8: Organic chemistry
  • NZ1_1: Molecular biology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Katolicki Uniwersytet Lubelski Jana Pawła II, Wydział Medyczny

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Oleh M. Demchuk 

Number of co-investigators in the project: 10

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 2 546 120 PLN

Project start date (Y-m-d): 2020-03-25

Project end date (Y-m-d): 2026-03-24

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (23)
  1. Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity
    Authors:
    Kula, K.; Nagatsky, R.; Sadowski, M.; Siumka, Y.; Demchuk, O.M.
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 5229), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28135229 - link to the publication
  2. Silver Is Not Equal to Silver: Synthesis and Evaluation of Silver Nanoparticles with Low Biological Activity, and Their Incorporation into C12Alanine-Based Hydrogel
    Authors:
    Konrad Kubiński, Kamila Górka, Monika Janeczko, Aleksandra Martyna, Mateusz Kwaśnik, Maciej Masłyk, Emil Zięba, Joanna Kowalczuk, Piotr Kuśtrowski, Mariusz Borkowski, Anna Boguszewska-Czubara, Agnieszka Klimeczek, Oleg M. Demchuk
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 1194), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28031194 - link to the publication
  3. Low-Molecular-Weight Organogelators Based on N-dodecanoyl-L-amino Acids—Energy Frameworks and Supramolecular Synthons
    Authors:
    Barbara Miroslaw, Oleg M. Demchuk, Roman Luboradzki, Katarzyna Tyszczuk-Rotko
    Academic press:
    Materials (rok: 2023, tom: 16, strony: 702), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma16020702 - link to the publication
  4. New supramolecular drug carriers: The study of organogel conjugated gold nanoparticles
    Authors:
    Joanna Kowalczuk, Andrzej Łapiński, Elżbieta Stolarczyk, Oleg M. Demchuk, Konrad Kubiński, Monika Janeczko, Aleksandra Martyna, Maciej Masłyk, Sylwia Turczyniak-Surdacka 4
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 7462), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26247462 - link to the publication
  5. Experimental and theoretical study of adsorption of synthesized amino acid core derived surfactants at an air/water interface
    Authors:
    M. Borkowski, S. Orvalho, P. Warszyński, Oleg M. Demchuk, E. Jareka, J. Zawala
    Academic press:
    Phys. Chem. Chem. Phys. (rok: 2022, tom: 24, strony: 3854), Wydawca: RCS
    Status:
    Published
    DOI:
    10.1039/D1CP05322A - link to the publication
  6. New supramolecular drug carriers: The study of organogel conjugated gold nanoparticles
    Authors:
    Joanna Kowalczuk, Andrzej Łapiński, Elżbieta Stolarczyk, Oleg M. Demchuk, Konrad Kubiński, Monika Janeczko, Aleksandra Martyna, Maciej Masłyk, Sylwia Turczyniak-Surdacka 4
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 7462), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26247462 - link to the publication
  7. Low-Molecular-Weight Organogelators Based on N-dodecanoyl-L-amino Acids—Energy Frameworks and Supramolecular Synthons
    Authors:
    Barbara Miroslaw, Oleg M. Demchuk, Roman Luboradzki, Katarzyna Tyszczuk-Rotko
    Academic press:
    Materials (rok: 2023, tom: 16, strony: 702), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma16020702 - link to the publication
  8. A Modular Approach to Atropisomeric Bisphosphines of Diversified Electronic Density on Phosphorus Atoms
    Authors:
    Demchuk, O.M.; Martyna, A.; Kwaśnik, M.; Szwaczko, K.; Strzelecka, D.; Mirosław, B.; Pietrusiewicz, K.M.; Urbanczyk-Lipkowska, Z.
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 5504), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27175504 - link to the publication
  9. An Efficient Asymmetric Cross-Coupling Reaction in Aqueous Media Mediated by Chiral Chelating Mono Phosphane Atropisomeric Biaryl Ligand
    Authors:
    Katarzyna Kapłon, Sławomir Frynas, Barbara Mirosław, Janusz Lipkowski, Oleg M. Demchuk
    Academic press:
    Catalysts (rok: 2023, tom: 13, strony: 353), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal13020353 - link to the publication
  10. New supramolecular drug carriers: The study of organogel conjugated gold nanoparticles
    Authors:
    Joanna Kowalczuk, Andrzej Łapiński, Elżbieta Stolarczyk, Oleg M. Demchuk, Konrad Kubiński, Monika Janeczko, Aleksandra Martyna, Maciej Masłyk, Sylwia Turczyniak-Surdacka 4
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 7462), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26247462 - link to the publication
  11. Arylcyanomethylenequinone Oximes: An Overview of Synthesis, Chemical Transformations, and Biological Activity
    Authors:
    Kula, K.; Nagatsky, R.; Sadowski, M.; Siumka, Y.; Demchuk, O.M.
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 5229), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28135229 - link to the publication
  12. Silver Is Not Equal to Silver: Synthesis and Evaluation of Silver Nanoparticles with Low Biological Activity, and Their Incorporation into C12Alanine-Based Hydrogel
    Authors:
    Konrad Kubiński, Kamila Górka, Monika Janeczko, Aleksandra Martyna, Mateusz Kwaśnik, Maciej Masłyk, Emil Zięba, Joanna Kowalczuk, Piotr Kuśtrowski, Mariusz Borkowski, Anna Boguszewska-Czubara, Agnieszka Klimeczek, Oleg M. Demchuk
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 1194), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28031194 - link to the publication
  13. An Efficient Asymmetric Cross-Coupling Reaction in Aqueous Media Mediated by Chiral Chelating Mono Phosphane Atropisomeric Biaryl Ligand
    Authors:
    Katarzyna Kapłon, Sławomir Frynas, Barbara Mirosław, Janusz Lipkowski, Oleg M. Demchuk
    Academic press:
    Catalysts (rok: 2023, tom: 13, strony: 353), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal13020353 - link to the publication
  14. Silver Is Not Equal to Silver: Synthesis and Evaluation of Silver Nanoparticles with Low Biological Activity, and Their Incorporation into C12Alanine-Based Hydrogel
    Authors:
    Konrad Kubiński, Kamila Górka, Monika Janeczko, Aleksandra Martyna, Mateusz Kwaśnik, Maciej Masłyk, Emil Zięba, Joanna Kowalczuk, Piotr Kuśtrowski, Mariusz Borkowski, Anna Boguszewska-Czubara, Agnieszka Klimeczek, Oleg M. Demchuk
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 1194), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28031194 - link to the publication
  15. A Single Biaryl Monophosphine Ligand Motif—The Multiverse of Coordination Modes
    Authors:
    Miroslaw, B.; Dybala, I.; Jasiński, R.; Demchuk, O.M.
    Academic press:
    Inorganics (rok: 2023, tom: 11, strony: 399), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/inorganics11100399 - link to the publication
  16. A Single Biaryl Monophosphine Ligand Motif—The Multiverse of Coordination Modes
    Authors:
    Miroslaw, B.; Dybala, I.; Jasiński, R.; Demchuk, O.M.
    Academic press:
    Inorganics (rok: 2023, tom: 11, strony: 399), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/inorganics11100399 - link to the publication
  17. New supramolecular drug carriers: The study of organogel conjugated gold nanoparticles
    Authors:
    Joanna Kowalczuk, Andrzej Łapiński, Elżbieta Stolarczyk, Oleg M. Demchuk, Konrad Kubiński, Monika Janeczko, Aleksandra Martyna, Maciej Masłyk, Sylwia Turczyniak-Surdacka 4
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 7462), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26247462 - link to the publication
  18. A Modular Approach to Atropisomeric Bisphosphines of Diversified Electronic Density on Phosphorus Atoms
    Authors:
    Demchuk, O.M.; Martyna, A.; Kwaśnik, M.; Szwaczko, K.; Strzelecka, D.; Mirosław, B.; Pietrusiewicz, K.M.; Urbanczyk-Lipkowska, Z.
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 5504), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27175504 - link to the publication
  19. An Efficient Asymmetric Cross-Coupling Reaction in Aqueous Media Mediated by Chiral Chelating Mono Phosphane Atropisomeric Biaryl Ligand
    Authors:
    Katarzyna Kapłon, Sławomir Frynas, Barbara Mirosław, Janusz Lipkowski, Oleg M. Demchuk
    Academic press:
    Catalysts (rok: 2023, tom: 13, strony: 353), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal13020353 - link to the publication
  20. Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity
    Authors:
    Michał Janowski, Oleg M. Demchuk, Monika Wujec
    Academic press:
    Molecules (rok: 2024, tom: 29, strony: 2855), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules29122855 - link to the publication
  21. Low-Molecular-Weight Organogelators Based on N-dodecanoyl-L-amino Acids—Energy Frameworks and Supramolecular Synthons
    Authors:
    Barbara Miroslaw, Oleg M. Demchuk, Roman Luboradzki, Katarzyna Tyszczuk-Rotko
    Academic press:
    Materials (rok: 2023, tom: 16, strony: 702), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma16020702 - link to the publication
  22. Experimental and theoretical study of adsorption of synthesized amino acid core derived surfactants at an air/water interface
    Authors:
    M. Borkowski, S. Orvalho, P. Warszyński, Oleg M. Demchuk, E. Jareka, J. Zawala
    Academic press:
    Phys. Chem. Chem. Phys. (rok: 2022, tom: 24, strony: 3854), Wydawca: RCS
    Status:
    Published
    DOI:
    10.1039/D1CP05322A - link to the publication
  23. A Modular Approach to Atropisomeric Bisphosphines of Diversified Electronic Density on Phosphorus Atoms
    Authors:
    Demchuk, O.M.; Martyna, A.; Kwaśnik, M.; Szwaczko, K.; Strzelecka, D.; Mirosław, B.; Pietrusiewicz, K.M.; Urbanczyk-Lipkowska, Z.
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 5504), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27175504 - link to the publication

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