Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of sphingosine kinases/sphingosine-1-phosphate dependent signaling in mice brains exposed to type II diabetes mellitus and high-fat diet. Searching for potential neuroprotective effects of fingolimod and metformin.

2018/29/N/NZ4/00616

Keywords:

type II diabetes sphingosine-1-phosphate fingolimod metformin brain

Descriptors:

  • NZ4_11: Metabolism
  • NZ4_9: Systems neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Przemysław Wencel 

Number of co-investigators in the project: 2

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 209 940 PLN

Project start date (Y-m-d): 2019-01-31

Project end date (Y-m-d): 2023-01-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Glukometr (300 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Fingolimod Modulates the Gene Expression of Proteins Engaged in Inflammation and Amyloid-Beta Metabolism and Improves Exploratory and Anxiety-Like Behavior in Obese Mice
    Authors:
    Przemyslaw Leonard Wencel, Kamilla Blecharz-Klin, Agnieszka Piechal, Justyna Pyrzanowska, Dagmara Mirowska-Guzel, Robert Piotr Strosznajder
    Academic press:
    Neurotherapeutics (rok: 2023, tom: online, strony: 45308), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s13311-023-01403-2 - link to the publication
  1. Anti-inflammatory role of metformin in brain cortex of pre-diabetic obese mice
    Authors:
    Przemyslaw Wencel, Robert Piotr Strosznajder
    Conference:
    35th ECNP Congress 2022 (rok: 2022, ), Wydawca: Elsevier, Neuroscience Applied
    Data:
    konferencja 15-18 October 2022
    Status:
    Published
  2. Fingolimod modulates genes expression of sphingosine-1-phoshate receptors and Sirt1 in diabetic mice brain
    Authors:
    Przemyslaw Wencel, Robert Piotr Strosznajder
    Conference:
    33rd ECNP Congress Virtual (rok: 2020, ), Wydawca: European Neuropsychopharmacology, Elsevier
    Data:
    konferencja 12-15 września 2020
    Status:
    Published
  3. Metformin modulates gene expression of inflammatory proteins and sphingosine kinase 2 in diabetic mice hippocampus
    Authors:
    Przemysław Leonard Wencel, Robert Piotr Strosznajder
    Conference:
    Neuropatologia Neuroscience (rok: 2021, ), Wydawca: Termedia, Folia Neuropathologica 2021; 59/4
    Data:
    konferencja 19 November, 2021
    Status:
    Published
  4. Fingolimod exerts anxiolytic effect and upregulates genes involved in neuronal survival and amyloid beta metabolism in diabetic mice hippocampus
    Authors:
    Przemysław Wencel, Kamilla Blecharz-Klin, Magdalena Świerczyńska, Agnieszka Piechal, Justyna Pyrzanowska, Dagmara Mirowska-Guzel, Robert Piotr Strosznajder
    Conference:
    34 th ECNP Congress, Hybrid (rok: 2021, ), Wydawca: Elsevier, European Neuropsychopharmacology, Volume 53, Supplement 1
    Data:
    konferencja 2-5 October 2021
    Status:
    Published

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