Projects funded by the NCN
The role of sphingosine kinases/sphingosine-1-phosphate dependent signaling in mice brains exposed to type II diabetes mellitus and high-fat diet. Searching for potential neuroprotective effects of fingolimod and metformin.
2018/29/N/NZ4/00616
Keywords:
type II diabetes sphingosine-1-phosphate fingolimod metformin brain
Descriptors:
- NZ4_11: Metabolism
- NZ4_9: Systems neurobiology
- NZ3_7: Signal transduction
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 15 - announced on 2018-03-15
Amount awarded: 209 940 PLN
Project start date (Y-m-d): 2019-01-31
Project end date (Y-m-d): 2023-01-30
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Glukometr (300 PLN)
Information in the final report
- Publication in academic press/journals (1)
- Articles in post-conference publications (4)
- Fingolimod Modulates the Gene Expression of Proteins Engaged in Inflammation and Amyloid-Beta Metabolism and Improves Exploratory and Anxiety-Like Behavior in Obese MiceAuthors:Przemyslaw Leonard Wencel, Kamilla Blecharz-Klin, Agnieszka Piechal, Justyna Pyrzanowska, Dagmara Mirowska-Guzel, Robert Piotr StrosznajderAcademic press:Neurotherapeutics (rok: 2023, tom: online, strony: 45308), Wydawca: Springer NatureStatus:PublishedDOI:10.1007/s13311-023-01403-2 - link to the publication