Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Regulation of carnitine transporters secretory pathway by AKT - a kinase hyperactivated in cancer cells

2018/31/B/NZ3/00669

Keywords:

Carnitine transporters AKT kinase Breast cancer cells

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction
  • NZ3_2: Cell physiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Katarzyna Nałęcz 

Number of co-investigators in the project: 3

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 275 200 PLN

Project start date (Y-m-d): 2019-07-01

Project end date (Y-m-d): 2022-12-31

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cieplarka 37oC do hodowli bakteryjnych (8 000 PLN)
  2. Aparat do elektroforezy (2 468 PLN)
  3. Inkubator CO2 do hodowli komórkowych typu "Cell Locker" z wnętrzem z miedzi, z filtrami (94 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. SLC22A5 (OCTN2) Carnitine Transporter - Indispensable for Cell metabolism, a Jekyll and Hyde of Human Cancer
    Authors:
    Juraszek B.,, Nałęcz K.A.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 14), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25010014 - link to the publication
  2. The activity and surface presence of organic cation/carnitine transporter OCTN2 (SLC22A5) in breast cancer cells depends on AKT kinase
    Authors:
    Papierniak-Wyglądała A., Lamch W., Jurewicz E. , Nałęcz K.A.
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2023, tom: 742, strony: 109616), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.106/j.abb.2023.109616 - link to the publication
  3. Trafficking of the cell surface amino acid transporter SLC6A14 upregulated in cancer is controlled by phosphorylation of SEC24C protein by AKT knase
    Authors:
    Kovalchuk V., Nalecz K.A.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 18000), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390?cells10071800 - link to the publication
  4. Amino acid transporter SLCA14 (ATB0,+) – A target in combined anti-cancer therapy
    Authors:
    Nałęcz K.A.
    Academic press:
    Front. Cell Dev. Biol. (rok: 2020, tom: 8, strony: 45304), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcell.2020.594464. - link to the publication

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