Projects funded by the NCN


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510 projects found matching your search criteria :

  1. Optogenetic and chemogenetic identification of brain circuits and cellular mechanisms underlying antidepressants resista...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: prof. Mariusz Papp

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  2. Analysis of a mechanism, mediators and sequence of events in the context of an assessment of stimulatory effect of senes...

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: dr hab. Krzysztof Książek

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

  3. Modulation of the N-glycosylation as a tool to improve the CAR-T immunotherapy efficacy

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Agnieszka Graczyk-Jarzynka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  4. Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Magdalena Wujak

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  5. More knowledge per hectare? Economic and environmental aspects of technological change stimulated by investments in prec...

    Call: SONATA 19 , Panel: HS4

    Principal investigator: dr Jakub Staniszewski

    Uniwersytet Ekonomiczny w Poznaniu

  6. Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza, Wydział Chemii

  7. Can extracts from Epilobium sp. inhibit proliferation of prostate cell LNCaP by influencing the activity of histone acet...

    Call: SONATA 1 , Panel: NZ4

    Principal investigator: dr hab. Anna Kiss

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

  8. Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

    Call: OPUS 26 , Panel: NZ5

    Principal investigator: dr Tomasz Prajsnar

    Uniwersytet Jagielloński, Wydział Biologii

  9. Functional and structural analysis of anticancer drugs as protein biosynthesis inhibitors

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr hab. Witold Szaflarski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

  10. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  11. Physiological significance and clinical implications of global and local inhibition of NRF2 transcriptional activity in ...

    Call: SONATA BIS 13 , Panel: NZ4

    Principal investigator: dr hab. Aleksandra Piechota-Polańczyk

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  12. Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

    Call: OPUS 25 , Panel: NZ5

    Principal investigator: prof. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

  13. Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

    Call: OPUS 25 , Panel: ST4

    Principal investigator: prof. Arkadiusz Chworoś

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  14. Compounds modulating function of telomeric proteins TRF1 and TRF2

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: prof. Maciej Bagiński

    Politechnika Gdańska, Wydział Chemiczny

  15. Unraveling protease activation in stimulated CAR-T cells to identify new biomarkers for assessing their clinical efficac...

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr hab. Małgorzata Firczuk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  16. Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr Anna Zawadzka

    Uniwersytet Warszawski, Wydział Chemii

  17. Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr hab. Magdalena Stobiecka

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

  18. Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Krzysztof Domka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  19. Understanding the contribution of immunoproteasome activation to the neuropathic pain development.

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr Natalia Małek-Chudzik

    Politechnika Wrocławska

  20. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  21. Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Marika Frańczak

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  22. The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Paulina Potok

    Uniwersytet Wrocławski, Wydział Chemii

  23. Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Alicja Braczko

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  24. Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Piotr Chyży

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  25. The effect of Tcf7l2 knockout on excitation/inhibition balance in neuronal circuits of the thalamus

    Call: PRELUDIUM 22 , Panel: NZ3

    Principal investigator: Katarzyna Hryniewiecka

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  26. Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

    Call: PRELUDIUM 22 , Panel: NZ6

    Principal investigator: dr Dorota Suszczyk

    Uniwersytet Medyczny w Lublinie

  27. Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Alex Matsuda

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  28. New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr Edyta Dyguda-Kazimierowicz

    Politechnika Wrocławska

  29. Efektywność nowatorskiej terapii inhibitorami JAK u pacjentów z reumatoidalnym zapaleniem stawów w odniesieniu do profil...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Sylwia Biały

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

  30. Construction of Candida famata flavinogenic yeast strains with improved ability to produce riboflavin in medium with lig...

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Dominik Wojdyła

    Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

  31. Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  32. Combining microfluidic-assisted biofabrication with high throughput proteomics to unravel skeletal muscle plasticity und...

    Call: SONATINA 7 , Panel: ST5

    Principal investigator: dr Nehar Celikkin

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  33. Electrical stimulation of Anterior Thalamic Nuclei for memory modulation

    Call: POLONEZ BIS 3 , Panel: NZ4

    Principal investigator: dr Maciej Jankowski

    Politechnika Gdańska

  34. Development of novel anti-cancer immunotherapy against mesothelioma comprising of oncolytic adenovirus vectors armed wit...

    Call: SONATA 18 , Panel: NZ7

    Principal investigator: dr Łukasz Kuryk

    Narodowy Instytut Zdrowia Publicznego PZH - Państwowy Instytut Badawczy

  35. Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

    Call: SONATA 18 , Panel: NZ6

    Principal investigator: dr Wioletta Rut

    Politechnika Wrocławska

  36. Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

    Call: POLONEZ BIS 3 , Panel: NZ7

    Principal investigator: dr hab. Aneta Radziwon-Balicka

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  37. Targeted inhibition of hypusination pathway

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: dr Przemysław Grudnik

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  38. Identification of key structural elements of immunomodulatory proteins - inhibitors of antigenic peptide transporter TAP...

    Call: SONATA 18 , Panel: NZ7

    Principal investigator: dr Natalia Karska

    Uniwersytet Gdański, Wydział Chemii

  39. The role of diet in the development of autoimmune diseases - new interleukin 15 inhibitors among dietary polyphenols and...

    Call: SONATA 18 , Panel: NZ9

    Principal investigator: dr Barbara Żyżyńska-Granica

    Warszawski Uniwersytet Medyczny

  40. RamanSense: Metabolomics based on Enhanced Stimulated Raman Microscopy

    Call: MAESTRO 14 , Panel: ST4

    Principal investigator: prof. Małgorzata Barańska

    Uniwersytet Jagielloński, Wydział Chemii

  41. Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

    Call: SONATA BIS 12 , Panel: ST4

    Principal investigator: dr Karolina Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  42. Multidimensional mechanistic investigations of trans spinal direct current stimulation in motor neuron disease.

    Call: JPND Call 2022 , Panel: NZ4

    Principal investigator: dr Marcin Bączyk

    Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu

  43. Histone demethylase inhibitors as chemosensitivity modulators in the treatment of head and neck squamous cell carcinoma

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Dawid Dorna

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  44. Selective determination of isoenzymatic lactate dehydrogenase activity in flow analysis format

    Call: PRELUDIUM 21 , Panel: NZ5

    Principal investigator: Justyna Głowacka

    Uniwersytet Warszawski, Wydział Chemii

  45. Rhythms of attention: The functional and causal role of neural oscillations in selective attention.

    Call: OPUS 23 , Panel: HS6

    Principal investigator: dr hab. Dariusz Asanowicz

    Uniwersytet Jagielloński, Wydział Filozoficzny

  46. Design, synthesis and in vitro and in vivo studies of anticancer potential of phosphonic and phosphinic analogs of sulfo...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: prof. Tadeusz Gajda

    POLITECHNIKA ŁÓDZKA, Wydział Chemiczny

  47. Mycogenic metal nanoparticles for plant growth stimulation and increased plant production.

    Call: PRELUDIUM 21 , Panel: NZ9

    Principal investigator: Joanna Trzcińska-Wencel

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Nauk Biologicznych i Weterynaryjnych

  48. Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

    Call: PRELUDIUM 21 , Panel: NZ1

    Principal investigator: Katarzyna Dziubek

    Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

  49. Mechanisms and therapeutic potential of SGLT2/SGLT1 and NHE-1 inhibition in a rat model of heart failure with preserved ...

    Call: OPUS 23 , Panel: NZ5

    Principal investigator: dr hab. Urszula Mackiewicz

    Centrum Medyczne Kształcenia Podyplomowego

  50. Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Kinga Czarnota-Łydka

    Uniwersytet Jagielloński, Collegium Medicum