Projects funded by the NCN
Metabolic stability and inhibition of P450 enzymes in combination with chemometric techniques as a tool for selection of new derivatives of arylpiperazine during the search of new antidepressants
2011/03/B/NZ1/03113
Keywords:
arylpiperazines andidepressants metabolism chemometrics
Descriptors:
- NZ1_2: Biochemistry
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Gdański Uniwersytet Medyczny, Wydział Farmcautyczny z Oddziałem Medycyny Laboratoryjnej
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: OPUS 2 - announced on 2011-09-15
Amount awarded: 298 250 PLN
Project start date (Y-m-d): 2012-08-22
Project end date (Y-m-d): 2015-08-21
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Spektrofotometr UV-vis (100 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Mass Spectrometry Based Identification of Geometric Isomers during Metabolic Stability Study of a New Cytotoxic Sulfonamide Derivatives Supported by Quantitative Structure-Retention RelationshipsAuthors:Mariusz Belka, Weronika Hewelt-Belka, Jarosław Sławiński, Tomasz BączekAcademic press:PLOS ONE (rok: 2014, tom: 9(6), strony: e968096), Wydawca: PLOSStatus:PublishedDOI:10.1371/journal.pone.0098096 - link to the publication
- Prediction of overall in vitro microsomal stability of drug candidates based on molecular modeling and support vector machines. Case study of novel arylpiperazines derivatives.Authors:Szymon Ulenberg, Mariusz Belka, Marek Król, Franciszek Herold, Weronika Hewelt-Belka, Agata Kot-Wasik, Tomasz BączekAcademic press:PlosONE (rok: 2015, tom: 10(3), strony: 1-16/16, dokument elektroniczny), Wydawca: Public Library of ScienceStatus:PublishedDOI:10.1371/journal.pone.0122772 - link to the publication