Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Search for novel mechanisms underlining inhibition of cancer cell proliferation by plant-derived nutraceuticals

2013/11/D/NZ7/00939

Keywords:

nutraceuticals cancer cells inhibition of cell proliferation

Descriptors:

  • NZ7_15: Toxicology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Rzeszowski, Wydział Biotechnologii

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Lewińska 

Number of co-investigators in the project: 4

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 488 402 PLN

Project start date (Y-m-d): 2014-07-10

Project end date (Y-m-d): 2018-07-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Analizator komórek (ilość komórek, przeżywalność, cykl komórkowy) (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (7)
  1. Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells.
    Authors:
    Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A, Wnuk M.
    Academic press:
    Apoptosis (rok: 2017, tom: 22, strony: 800-815), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-017-1353-7 - link to the publication
  2. Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells.
    Authors:
    Lewinska A, Adamczyk J, Pajak J, Stoklosa S, Kubis B, Pastuszek P, Slota E, Wnuk M.
    Academic press:
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis (rok: 2014, tom: 771, strony: 43–52), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrgentox.2014.07.001 - link to the publication
  3. Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation.
    Authors:
    Lewinska A, Bednarz D, Adamczyk-Grochala J, Wnuk M.
    Academic press:
    Redox Biology (rok: 2017, tom: 12, strony: 469-482), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2017.03.014 - link to the publication
  4. Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells.
    Authors:
    Lewinska A, Jarosz P, Czech J, Rzeszutek I, Bielak-Zmijewska A, Grabowska W, Wnuk M.
    Academic press:
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis (rok: 2015, tom: 779, strony: 23-34), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrgentox.2015.02.003 - link to the publication
  5. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity.
    Authors:
    Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A, Wnuk M.
    Academic press:
    Toxicology Letters (rok: 2017, tom: 265, strony: 117–130), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2016.11.018 - link to the publication
  6. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.
    Authors:
    Lewinska A, Siwak J, Rzeszutek I, Wnuk M.
    Academic press:
    Toxicology in Vitro (rok: 2015, tom: 29, strony: 417-425), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2014.12.005 - link to the publication
  7. Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide.
    Authors:
    Lewinska A, Chochrek P, Smolag K, Rawska E, Wnuk M.
    Academic press:
    Redox Report: Communications in Free Radical Research (rok: 2015, tom: 20, strony: 116-125), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1179/1351000214Y.0000000113 - link to the publication
  8. Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells.
    Authors:
    Lewinska A, Adamczyk-Grochala J, Deregowska A, Wnuk M.
    Academic press:
    Theranostics (rok: 2017, tom: 7, strony: 3461-3477), Wydawca: Ivyspring International Publisher
    Status:
    Published
    DOI:
    10.7150/thno.20657 - link to the publication
  1. Ribotoxic stress and shifts in glycolytic pathway-based cytostatic action of selected nutraceuticals in breast cancer cells of different receptor status.
    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Ewa Kwasniewicz, Anna Lewinska.
    Conference:
    FUTURE OF AGING, 10th European Congress of Biogerontology and 6th Biogerontological Meeting of the Polish Academy of Sciences, Nencki Institute, Warsaw, Poland (rok: 2016, ), Wydawca: Nencki Institute
    Data:
    konferencja 23-24.09.2016
    Status:
    Published
  2. A complex response to nutraceutical stimulation in phenotypically different breast cancer cell lines.
    Authors:
    Anna Lewinska, Jagoda Adamczyk, Anna Deregowska, Ewa Kwasniewicz, Maciej Wnuk.
    Conference:
    FUTURE OF AGING, 10th European Congress of Biogerontology and 6th Biogerontological Meeting of the Polish Academy of Sciences, Nencki Institute, Warsaw, Poland (rok: 2016, ), Wydawca: Nencki Institute
    Data:
    konferencja 23-24.09.2016
    Status:
    Published
  3. PHYTOCHEMICALS AFFECT NUCLEOLUS STATE AND INDUCE CELL CYCLE ARREST AND SENESCENCE IN BREAST CANCER CELLS
    Authors:
    Maciej Wnuk, Diana Bednarz, Jagoda Adamczyk-Grochala, Anna Lewinska.
    Conference:
    IUBMB Focused Meeting on Molecular aspects of aging and longevity, Athens, Greece (rok: 2017, ), Wydawca: National Hellenic Research Foundation
    Data:
    konferencja 16-19.10.2017
    Status:
    Published
  4. Pleiotropic anticancer activity of selected nutraceuticals against MCF-7, MDA-MB-231 and SK-BR-3 breast cancer cell lines.
    Authors:
    Anna Lewinska, Jagoda Adamczyk, Anna Deregowska, Maciej Wnuk.
    Conference:
    41st FEBS Congress, Molecular and Systems Biology for a Better Life, Ephesus/Kuşadasi, Turkey (rok: 2016, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 3-8.09.2016 (planowana, ale odwołana; suplement jednak upowszechniono w FEBS Journal)
    Status:
    Published
  5. CYTOSTATIC AND PRO-SENESCENT ACTIVITY OF SULFORAPHANE IS MEDIATED BY DNA HYPOMETHYLATION AND CHANGES IN MICRORNA PROFILE IN BREAST CANCER CELLS
    Authors:
    Anna Lewinska, Jagoda Adamczyk-Grochala, Anna Deregowska, Maciej Wnuk.
    Conference:
    IUBMB Focused Meeting on Molecular aspects of aging and longevity, Athens, Greece (rok: 2017, ), Wydawca: National Hellenic Research Foundation
    Data:
    konferencja 16-19.10.2017
    Status:
    Published
  6. Nutraceutical-induced ribotoxic stress in MCF-7, MDA-MB-231 and SK-BR-3 breast cancer cell lines.
    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Anna Lewinska.
    Conference:
    41st FEBS Congress, Molecular and Systems Biology for a Better Life, Ephesus/Kuşadasi, Turkey (rok: 2016, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 3-8.09.2016 (planowana, ale odwołana; suplement jednak upowszechniono w FEBS Journal)
    Status:
    Published
  7. Nutraceuticals induce ribotoxic stress in breast cancer cells MCF-7, MDA-MB-231 and SK-BR-3.
    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Ewa Kwasniewicz, Anna Lewinska.
    Conference:
    Cell Fate Diversity in Aging Conference, Dubrovnik, Croatia (rok: 2016, ), Wydawca: Zing Conferences
    Data:
    konferencja 25-28.09.2016
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy