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Search for novel mechanisms underlining inhibition of cancer cell proliferation by plant-derived nutraceuticals

2013/11/D/NZ7/00939

Keywords

Descriptors

  • NZ7_15: Toksykologia
  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ7_16: Inne zagadnienia pokrewne

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Rzeszowski

Voivodeship: podkarpackie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Anna Lewińska

Number of co-investigators in the project: 4

Call

SONATA 6 – announced on 2013-09-16

Amount awarded
488 402 PLN
Project start date
2014-07-10
Project end date
2018-07-09
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Analizator komórek (ilość komórek, przeżywalność, cykl komórkowy). Cost: 70 000 PLN

Information in the final report

Publication in academic press/journals (8)

  1. Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells.

    Authors:
    Lewinska A, Adamczyk-Grochala J, Deregowska A, Wnuk M.
    Academic press:
    Theranostics (year: 2017, volume: 7, pages: 3461-3477), Publisher: Ivyspring International Publisher
    Status:
    Published
    DOI:
    10.7150/thno.20657 – link to the publication

  2. Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation.

    Authors:
    Lewinska A, Bednarz D, Adamczyk-Grochala J, Wnuk M.
    Academic press:
    Redox Biology (year: 2017, volume: 12, pages: 469-482), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2017.03.014 – link to the publication

  3. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.

    Authors:
    Lewinska A, Siwak J, Rzeszutek I, Wnuk M.
    Academic press:
    Toxicology in Vitro (year: 2015, volume: 29, pages: 417-425), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2014.12.005 – link to the publication

  4. Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells.

    Authors:
    Lewinska A, Adamczyk J, Pajak J, Stoklosa S, Kubis B, Pastuszek P, Slota E, Wnuk M.
    Academic press:
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis (year: 2014, volume: 771, pages: 43–52), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrgentox.2014.07.001 – link to the publication

  5. Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide.

    Authors:
    Lewinska A, Chochrek P, Smolag K, Rawska E, Wnuk M.
    Academic press:
    Redox Report: Communications in Free Radical Research (year: 2015, volume: 20, pages: 116-125), Publisher: Taylor and Francis
    Status:
    Published
    DOI:
    10.1179/1351000214Y.0000000113 – link to the publication

  6. Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells.

    Authors:
    Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A, Wnuk M.
    Academic press:
    Apoptosis (year: 2017, volume: 22, pages: 800-815), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-017-1353-7 – link to the publication

  7. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity.

    Authors:
    Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A, Wnuk M.
    Academic press:
    Toxicology Letters (year: 2017, volume: 265, pages: 117–130), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2016.11.018 – link to the publication

  8. Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells.

    Authors:
    Lewinska A, Jarosz P, Czech J, Rzeszutek I, Bielak-Zmijewska A, Grabowska W, Wnuk M.
    Academic press:
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis (year: 2015, volume: 779, pages: 23-34), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrgentox.2015.02.003 – link to the publication

Articles in post-conference publications (7)

  1. A complex response to nutraceutical stimulation in phenotypically different breast cancer cell lines.

    Authors:
    Anna Lewinska, Jagoda Adamczyk, Anna Deregowska, Ewa Kwasniewicz, Maciej Wnuk.
    Conference:
    FUTURE OF AGING, 10th European Congress of Biogerontology and 6th Biogerontological Meeting of the Polish Academy of Sciences, Nencki Institute, Warsaw, Poland (year: 2016, pages: P35), Publisher: Nencki Institute
    Date:
    conference 23-24.09.2016
    Status:
    Published

  2. Ribotoxic stress and shifts in glycolytic pathway-based cytostatic action of selected nutraceuticals in breast cancer cells of different receptor status.

    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Ewa Kwasniewicz, Anna Lewinska.
    Conference:
    FUTURE OF AGING, 10th European Congress of Biogerontology and 6th Biogerontological Meeting of the Polish Academy of Sciences, Nencki Institute, Warsaw, Poland (year: 2016, pages: P34), Publisher: Nencki Institute
    Date:
    conference 23-24.09.2016
    Status:
    Published

  3. Pleiotropic anticancer activity of selected nutraceuticals against MCF-7, MDA-MB-231 and SK-BR-3 breast cancer cell lines.

    Authors:
    Anna Lewinska, Jagoda Adamczyk, Anna Deregowska, Maciej Wnuk.
    Conference:
    41st FEBS Congress, Molecular and Systems Biology for a Better Life, Ephesus/Kuşadasi, Turkey (year: 2016, pages: 388), Publisher: John Wiley & Sons, Inc.
    Date:
    conference 3-8.09.2016 (planowana, ale odwołana; suplement jednak upowszechniono w FEBS Journal)
    Status:
    Published

  4. Nutraceuticals induce ribotoxic stress in breast cancer cells MCF-7, MDA-MB-231 and SK-BR-3.

    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Ewa Kwasniewicz, Anna Lewinska.
    Conference:
    Cell Fate Diversity in Aging Conference, Dubrovnik, Croatia (year: 2016, pages: 92), Publisher: Zing Conferences
    Date:
    conference 25-28.09.2016
    Status:
    Published

  5. PHYTOCHEMICALS AFFECT NUCLEOLUS STATE AND INDUCE CELL CYCLE ARREST AND SENESCENCE IN BREAST CANCER CELLS

    Authors:
    Maciej Wnuk, Diana Bednarz, Jagoda Adamczyk-Grochala, Anna Lewinska.
    Conference:
    IUBMB Focused Meeting on Molecular aspects of aging and longevity, Athens, Greece (year: 2017, pages: 80), Publisher: National Hellenic Research Foundation
    Date:
    conference 16-19.10.2017
    Status:
    Published

  6. Nutraceutical-induced ribotoxic stress in MCF-7, MDA-MB-231 and SK-BR-3 breast cancer cell lines.

    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Anna Lewinska.
    Conference:
    41st FEBS Congress, Molecular and Systems Biology for a Better Life, Ephesus/Kuşadasi, Turkey (year: 2016, pages: 388), Publisher: John Wiley & Sons, Inc.
    Date:
    conference 3-8.09.2016 (planowana, ale odwołana; suplement jednak upowszechniono w FEBS Journal)
    Status:
    Published

  7. CYTOSTATIC AND PRO-SENESCENT ACTIVITY OF SULFORAPHANE IS MEDIATED BY DNA HYPOMETHYLATION AND CHANGES IN MICRORNA PROFILE IN BREAST CANCER CELLS

    Authors:
    Anna Lewinska, Jagoda Adamczyk-Grochala, Anna Deregowska, Maciej Wnuk.
    Conference:
    IUBMB Focused Meeting on Molecular aspects of aging and longevity, Athens, Greece (year: 2017, pages: 67), Publisher: National Hellenic Research Foundation
    Date:
    conference 16-19.10.2017
    Status:
    Published

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