Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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New approaches towards modulating selective and functional activities of antisense oligonucleotides

2011/03/B/ST5/01098

Keywords:

antisense oligonucleotides inhibition biological activity of RNA chemical synthesis of oligonucleotides parallel duplexes triplexes nanomaterials

Descriptors:

  • ST5_16:
  • ST5_20:
  • ST5_10: Functional materials/nanomaterials, nanoparticles

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Kierzek 

Number of co-investigators in the project: 6

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 820 280 PLN

Project start date (Y-m-d): 2012-08-29

Project end date (Y-m-d): 2015-08-28

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. aparat do selekcji promieniowania fluorescencyjnego.
  2. Aparat RT-PCR (150 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  1. Microarrays for identifying binding sites and probing structure of RNAs.
    Authors:
    R. Kierzek, D.H. Turner, E. Kierzek
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: 43, strony: 45303), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/nar/gku1303 - link to the publication
  2. Structural determinants for alternative splicing regulation of the MAPT pre-mRNA.
    Authors:
    J. Lisowiec, D. Magner, E. Kierzek, E. Lenatrowicz, R. Kierzek
    Academic press:
    RNA biology (rok: 2015, tom: 12, strony: 330-342), Wydawca: TAYLOR & FRANCIS INC
    Status:
    Published
    DOI:
    10.1080/15476286.2015.1017214 - link to the publication
  3. Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats.
    Authors:
    M. Malgowska, D. Gudanis, R. Kierzek, E. Wyszko, V. Gabelica, Z. Gdaniec
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 10196-10207), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gku710 - link to the publication
  4. Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides
    Authors:
    Y. Zhou, E. Kierzek, Z.P. Loo, M. Antonio, Y.H. Yau, Y.W. Chuah, S. Geifman-Shochat, R. Kierzek and G. Chen
    Academic press:
    Nucleic Acids Research (rok: 2013, tom: 41, strony: 6664-6673), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkt352 - link to the publication
  5. Synthesis, physicochemical and biochemical studies of anti-IRS-1 oligonucleotides containing carborane and/or metallacarborane modification.
    Authors:
    A.B. Olejniczak, R. Kierzek, E. Wickstrom, Z. J. Lesnikowski
    Academic press:
    J. Organometallic Chem (rok: 2013, tom: 747, strony: 201-210), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.organchem.2013.05.022 - link to the publication
  6. Novel Conformation of an RNA structural switch.
    Authors:
    S.D. Kennedy, R. Kierzek, D.H. Turner
    Academic press:
    Biochemistry (rok: 2012, tom: 51, strony: 9257-9259), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/bi301372t - link to the publication
  7. The contribution of pseudouridine to stabilities and structure of RNAs
    Authors:
    E. Kierzek, M.Malgowska, J. Lisowiec, D.H. Turner, Z. Gdaniec and R. Kierzek
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 3492-3501), Wydawca: Oxford university Press
    Status:
    Published
    DOI:
    10.1093/nar/gkt1330 - link to the publication
  8. Metal-promoted synthesis, characterization, crystal structure and RNA cleavage ability of 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone) lanthanide complexes
    Authors:
    M. Kozlowski, R. Kierzek, M. Kubicki and W. Radecka-Paryzek
    Academic press:
    J. Inorgan. Biochem. (rok: 2013, tom: 126, strony: 38-45), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2013.05.005 - link to the publication
  9. Ultrahigh-resolution crystal structures of Z-DNA in complex with Mn2+ and Zn2+ ions
    Authors:
    P. Drozdzal, M. Gilski, R. Kierzek, L. Lomozik and M. Jaskolski
    Academic press:
    Acta crystallographica, section D (rok: 2013, tom: 69, strony: 1180-1190), Wydawca: IUCr
    Status:
    Published
    DOI:
    10.1107/S0907444913007798 - link to the publication
  10. Unlocked nucleic acids: implications of increased conformational flexibility for RNA/DNA triplex formation.
    Authors:
    W. Kotkowiak, M. Kotkowiak, R. Kierzek, A. Pasternak
    Academic press:
    Biochemical Journal (rok: 2014, tom: 464, strony: 203-211), Wydawca: Portland Press Limited
    Status:
    Published
    DOI:
    10.1042/BJ20141023 - link to the publication
  11. Secondary Structure of a Conserved Domain in the Intron of Influenza A NS1 mRNA
    Authors:
    S.F. Priore, E. Kierzek, R. Kierzek, J.R. Baman; W.N. Moss; L.I. Dela-Moss, D.H. Turner
    Academic press:
    PLOS ONE (rok: 2013, tom: 8, strony: e70615), Wydawca: Plos org
    Status:
    Published
    DOI:
    10.137/journal.pone.0070615 - link to the publication

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