Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Conjugates of cap analogs with nanomaterials and biomolecules with potential applications in pharmacology or diagnostics

2011/01/D/ST5/05869

Keywords:

nucleotide synthesis ribonucleic acid dodecahedron magnetic nanoparticles graphene nanoencapsulation inhibition of translation cap binding proteins eIF4E

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_16:
  • ST5_10: Functional materials/nanomaterials, nanoparticles

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Kowalska 

Number of co-investigators in the project: 20

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 941 000 PLN

Project start date (Y-m-d): 2011-12-13

Project end date (Y-m-d): 2016-12-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Spektrometr FT-IR (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (10)
  1. Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC
    Authors:
    Przemyslaw Wanat, Sylwia Walczak, Blazej A. Wojtczak, Monika Nowakowska, Jacek Jemielity, Joanna Kowalska*
    Academic press:
    Organic Letters (rok: 2015, tom: 17, strony: 3062-3065), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.orglett.5b01346 - link to the publication
  2. Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes
    Authors:
    Joanna Kowalska, Anna Wypijewska del Nogal, Zbigniew M. Darzynkiewicz, Janina Buck, Corina Nicola, Andreas N. Kuhn, Maciej Lukaszewicz, Joanna Zuberek, Malwina Strenkowska, Marcin Ziemniak, Maciej Maciejczyk, Elzbieta Bojarska, Robert E. Rhoads, Edward Darzynkiewicz, Ugur Sahin and Jacek Jemielity*
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 10245-10264), Wydawca: OXFORD Univ Press
    Status:
    Published
    DOI:
    10.1093/nar/gku757 - link to the publication
  3. mRNA Cap Modification through Carbamate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation
    Authors:
    Marcin Warminski,† Zofia Warminska,† Joanna Kowalska,* Jacek Jemielity*
    Academic press:
    European Journal of Organic Chemistry (rok: 2015, tom: 2015, strony: 6153-6169), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    10.1002/ejoc.201500672 - link to the publication
  4. Bromide-doped polypyrrole microcapsules modified with gold nanoparticles
    Authors:
    Krystyna Kijewska, Paulina Głowala, Katarzyna Wiktorska, Marcin Pisarek, Jarosław Stolarski, Daria Kępińska, Marianna Gniadeka, Maciej Mazur*
    Academic press:
    Polymer (rok: 2012, tom: 53, strony: 5320-5329), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymer.2013.06.029 - link to the publication
  5. Magnetic-Nanoparticle-Decorated Polypyrrole Microvessels: Toward Encapsulation of mRNA Cap Analogues
    Authors:
    Krystyna Kijewska, Anita Jarzębińska, Joanna Kowalska, Jacek Jemielity, Daria Kępińska, Jacek Szczytko, Marcin Pisarek, Katarzyna Wiktorska, Jarosław Stolarski, Paweł Krysiński, Andrzej Twardowski, Maciej Mazur*
    Academic press:
    Biomacromolecules (rok: 2013, tom: 14, strony: 1867-1876), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/bm400250g - link to the publication
  6. Potential therapeutic applications of RNA cap analogs
    Authors:
    Marcin Ziemniak, Malwina Strenkowska, Joanna Kowalska,* Jacek Jemielity*
    Academic press:
    Future Medicinal Chemistry (rok: 2013, tom: 5, strony: 1141-1172), Wydawca: Future Science Group
    Status:
    Published
    DOI:
    10.4155/fmc.13.96 - link to the publication
  7. Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma
    Authors:
    Monika Zochowska, Anne-Christine Piguet, Jacek Jemielity, Joanna Kowalska, Ewa Szolajska, Jean-François Dufour, Jadwiga Chroboczek
    Academic press:
    Nanomedicine: Nanotechnology, Biology and Medicine (rok: 2015, tom: 11, strony: 67-76), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.nano.2014.07.009 - link to the publication
  8. Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to Decapping Scavenger activity monitoring
    Authors:
    Renata Kasprzyk, Joanna Kowalska*, Zbigniew Wieczorek, Mariusz Szabelski, Ryszard Stolarski, Jacek Jemielity*
    Academic press:
    Organic & Biomolecular Chemistry (rok: 2016, tom: 14, strony: 3863-3868), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C6OB00419A - link to the publication
  9. Encapsulation of Nile Red in polypyrrole microvessels
    Authors:
    Daria Kępińska, Adam Budniak, Krystyna Kijewska, G.J. Blanchard, Maciej Mazur*
    Academic press:
    Polymer (rok: 2013, tom: 54, strony: 4538-4544), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymer.2013.06.029 - link to the publication
  10. Gold-decorated polymer vessel structures as carriers of mRNA cap analogs
    Authors:
    Krystyna Kijewska, Paulina Głowala, Joanna Kowalska, Jacek Jemielity, Katarzyna Kaczyńska, Katarzyna Janiszewska, Jarosław Stolarski, Gary J. Blanchard, Daria Kępińska, Katarzyna Lubelska, Katarzyna Wiktorska, Marcin Pisarek, Maciej Mazur*
    Academic press:
    Polymer (rok: 2015, tom: 57, strony: 77-87), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.polymer.2014.12.019 - link to the publication
  11. Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves
    Authors:
    Malwina Strenkowska , Przemyslaw Wanat , Marcin Ziemniak , Jacek Jemielity*, and Joanna Kowalska*
    Academic press:
    Organic Letters (rok: 2012, tom: 14 (18), strony: 4782–4785), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/ol302071f - link to the publication
  1. Properties and applications of amino- or carboxy- funcionalized mRNA 5'-cap analogues and their conjugates
    Authors:
    Zofia Tomasiewicz, Marcin Warmiński, Krystian Ubych, Maciej Łukaszewicz, Joanna Żuberek, Anna Kropiwnicka, Edward Darżynkiewicz, Joanna Kowalska, Jacek Jemielity
    Conference:
    XVIth Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13 czerwca
    Status:
    Published
  2. Synthesis and properties of cap-decorated gold nanoparticles
    Authors:
    Maciej Majewski, Malwina Strenkowska, Joanna Żuberek, Joanna Kowalska, Jacek Jemielity
    Conference:
    XVIth Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13 czerwca
    Status:
    Published
  3. Synthesis and properties of mRNA cap analogs designed for ESR experiments
    Authors:
    Paulina Wysmołek, Michał Kopciał, Marcin Warmiński, Monika Nowakowska, Joanna Kowalska, Aneta Drabińska
    Conference:
    XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (rok: 2016, ), Wydawca: Institut Pasteur, Paris, France
    Data:
    konferencja 18-22 lipca
    Status:
    Published
  4. Synthesis of amino- or carboxy-functionalized mRNA cap analogs for fluorescence labeling and conjugation with macromolecules
    Authors:
    Marcin Warmiński, Zofia Tomasiewicz, Krystian Ubych, Joanna Kowalska, Jacek Jemielity
    Conference:
    XVIth Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13 czerwca
    Status:
    Published
  5. Synthesis and properties of dinucleotide 5' mRNA cap analogs containing azide linker incorporated to ribose of 7-methylguanosine
    Authors:
    Adam Mamot, Marcin Warmiński, Paweł Sikorski, Joanna Kowalska, Jacek Jemielity
    Conference:
    XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (rok: 2016, ), Wydawca: Institut Pasteur, Paris, France
    Data:
    konferencja 18-22 lipca
    Status:
    Published
  6. "Synthesis and properties of nucleotides containing a fluorophosphate moiety" - oral communication
    Authors:
    Joanna Kowalska, Marek R. Baranowski, Anna Nowicka, Renata Kasprzyk, Joanna Żuberek, Jacek Wójcik, Jacek Jemielity
    Conference:
    XVIth Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13 czerwca
    Status:
    Published
  7. Novel alkyne-containing C-phosphonate nucleotide analogs: synthesis and reactivity in CuAAC
    Authors:
    Przemysław Wanat, Sylwia Walczak, Błażej Wojtczak, Monika Nowakowska, Jacek Jemielity, Joanna Kowalska
    Conference:
    XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (rok: 2016, ), Wydawca: Institut Pasteur, Paris, France
    Data:
    konferencja 18-22 lipca
    Status:
    Published
  8. "Utility of chemically modified cap analogues in studying Dcp1/2 decapping complex mehanism of action" - oral communication
    Authors:
    Marcin Ziemniak, Jeff Mugridge, Joanna Kowalska, Agnieszka Stelmachowska, Joanna Żuberek, Edward Darżynkiewicz, John D. Gross, Robert E. Rhoads, Jacek Jemielity
    Conference:
    XVIth Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13 czerwca
    Status:
    Published
  9. Acetylpyrene-labelled 7-methylguanine nucleotides as fluorescent probes: application to Decapping Scavenger activity monitoring
    Authors:
    Joanna Kowalska, Renata Kasprzyk, Zbigniew Wieczorek, Mariusz Szabelski, Ryszard Stolarski, Jacek Jemielity
    Conference:
    XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (rok: 2016, ), Wydawca: Institut Pasteur, Paris, France
    Data:
    konferencja 18-22 lipca
    Status:
    Published
  10. Synthesis and properties of dinucleotide cap analogs containing a triazole ring within the oligophosphate bridge
    Authors:
    Sylwia Walczak, Przemysław Wanat, Anna Nowicka, Joanna Żuberek, Joanna Kowalska, Jacek Jemielity
    Conference:
    XVIth Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13 czerwca
    Status:
    Published

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