Projects funded by the NCN


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73 projects found matching your search criteria :

  1. Integrating multimodal, multiscale imaging and artificial intelligence for early amyloid detection in their native envir...

    Call: JPND Call 2024 , Panel: NZ2

    Principal investigator: prof. Aleksandra Maria Szczepankiewicz

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  2. Twistable light: Tunable chiral luminescent supramolecular hydrogels based on amyloid fibrils

    Call: PRELUDIUM 23 , Panel: ST4

    Principal investigator: Aleksandra Urszula Kołodziejczyk

    Uniwersytet Jagielloński

  3. Effect of phosphorylation of Aβ peptides on the redox activity oftheir copper complexes and aggregation in the context o...

    Call: SONATA 19 , Panel: ST4

    Principal investigator: dr Nina Ewa Wezynfeld

    Politechnika Warszawska, Wydział Chemiczny

  4. Taming aggregation with AmyloGraph 2.0: a database and prediction models of amyloid self-assembly modulators

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Michał Jan Burdukiewicz

    Uniwersytet Medyczny w Białymstoku

  5. Impact of Lactic Acid Fermentation on Sour Cherry (Prunus cerasus L.) Juice: Flavonols Composition and Health Implicatio...

    Call: SONATA 19 , Panel: NZ9

    Principal investigator: dr Kamila Borowiec

    Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii

  6. PROteolysis TArgeting Chimeras (PROTACs) intended to knock down excessive amyloidogenic proteins, human islet amyloid po...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr hab. Elżbieta Jankowska

    Uniwersytet Gdański, Wydział Chemii

  7. Neuroprotective effect of SGLT2i: direct influence on amyloid-β related pathology

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Agnieszka Pawlos

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  8. Multilevel chirality, reversibility and polymorphism of amyloid fibril superstructures

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr hab. Agnieszka Justyna Kaczor

    Uniwersytet Jagielloński, Wydział Chemii

  9. Local molecular changes in amyloid-β altered by green tea's active compounds

    Call: PRELUDIUM 22 , Panel: ST4

    Principal investigator: Michał Andrzej Czaja

    Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  10. Impact of metal and metal oxide nanoparticle functionalization by low-molar mass polyphenols on their activity in protei...

    Call: PRELUDIUM BIS 4 , Panel: ST5

    Principal investigator: dr hab. Magdalena Katarzyna Oćwieja

    Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

  11. Tracing the fibrillation mechanism by nanospectroscopic profiling of structure-dependent tau protein aggregation

    Call: SONATA 17 , Panel: ST4

    Principal investigator: dr Kamila Sofińska

    Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  12. Multi-scale method for amyloid fibril assembly using protofilament structures predicted by coarse-grained docking simula...

    Call: OPUS 22 , Panel: NZ2

    Principal investigator: dr Michał Koliński

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  13. Bleomycin hydrolase, homocysteine metabolism, epigenetic regulation of mTOR signalling, autophagy, and Alzheimer's disea...

    Call: OPUS 22 , Panel: NZ4

    Principal investigator: dr hab. Joanna Perła-Kaján

    Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

  14. Laser Emission of Thioflavin T and its analogues to uncover the early symptoms of neurodegenerative diseases.

    Call: SONATA 17 , Panel: ST4

    Principal investigator: dr Piotr Hańczyc

    Uniwersytet Warszawski, Wydział Fizyki

  15. Origins of amyloid disaggregation in double β-barrel J-domain protein family.

    Call: OPUS 21 , Panel: NZ8

    Principal investigator: dr Bartłomiej Piotr Tomiczek

    Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  16. Design of metal-peptide complexes based on amyloid β sequence with a His-2 binding motif as selective receptors in elect...

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Aleksandra Magdalena Tobolska

    Politechnika Warszawska

  17. Potential neuroprotective properties of modulators of sphingosine-1-phosphate (S1P) receptors (fingolimod and siponimod)...

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: Iga Wieczorek

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  18. Molecular basis of neurodegenerative diseases - the influence of selected metallic nanoparticles

    Call: OPUS 21 , Panel: ST4

    Principal investigator: prof. Maciej Leszek Kozak

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

  19. Spectroelectrochemistry of Alzheimer's disease - a study of a new potential therapeutic molecule

    Call: SONATINA 5 , Panel: ST4

    Principal investigator: dr Magdalena Zofia Wiloch

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  20. In solution or in the membrane? Determination of partition of beta-amyloid peptides between the water and phospholipid p...

    Call: OPUS 19 , Panel: ST4

    Principal investigator: prof. Wojciech Bal

    Instytut Biochemii i Biofizyki PAN

  21. Direct monitoring of the local dynamic rearrangement of the Alzheimer's peptides secondary structure upon the aggregatio...

    Call: OPUS 19 , Panel: ST4

    Principal investigator: dr hab. Ewelina Lipiec

    Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  22. New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Anna Marta Pasieka

    Uniwersytet Jagielloński, Collegium Medicum

  23. Structural studies of the influence of selected surfactants on the amyloidogenic properties of various forms of beta pep...

    Call: ETIUDA 8 , Panel: ST4

    Principal investigator: Michalina Maria Wilkowska

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

  24. Novel role of peroxisome proliferator-activated receptor α in the regulationof amyloid β peptide metabolism and mitochon...

    Call: PRELUDIUM 18 , Panel: NZ4

    Principal investigator: dr Sylwia Żulińska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  25. UNDERSTANDING CROSS-TALK BETWEEN AMYLOID PROTEINS

    Call: OPUS 18 , Panel: NZ2

    Principal investigator: prof. Małgorzata Kotulska

    Politechnika Wrocławska

  26. Design of photoswitchable dismantlers of biomaterials made of amyloid fibrils.

    Call: OPUS 16 , Panel: ST4

    Principal investigator: dr Dorota Anna Niedziałek

    Instytut Biochemii i Biofizyki PAN

  27. The role of BET family proteins in microglia-dependent neurodegeneration; relevance to Alzheimer's disease

    Call: OPUS 16 , Panel: NZ4

    Principal investigator: dr hab. Grzegorz Arkadiusz Czapski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  28. Dystrybucja jonów miedzi pomiędzy peptydami amyloidu beta a biomolekułami obecnymi w szczelinie synaptycznej w kontekści...

    Call: ETIUDA 6 , Panel: NZ1

    Principal investigator: Ewelina Stefaniak

    Instytut Biochemii i Biofizyki PAN

  29. Structures of oligomers of amyloid beta peptides: Multiscale molecular simulations.

    Call: PRELUDIUM 14 , Panel: NZ1

    Principal investigator: Dinh Quoc Huy Pham

    Instytut Fizyki PAN

  30. Mechanisms of binding and transport in plasma of amyloid beta oligomers by human serum albumin (HSA) in presence of sele...

    Call: OPUS 14 , Panel: ST4

    Principal investigator: prof. Maciej Leszek Kozak

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

  31. On the role of gangliosides, insulin and zinc ions in amylin interactions with biomimetic membranes

    Call: SONATA 13 , Panel: ST4

    Principal investigator: dr Joanna Gabriela Juhaniewicz-Dębińska

    Uniwersytet Warszawski, Wydział Chemii

  32. Influence of hydration water properties on the process of amyloid fibrils formation

    Call: SONATA 13 , Panel: NZ1

    Principal investigator: dr hab. Piotr Bruździak

    Politechnika Gdańska, Wydział Chemiczny

  33. The self-assembly of superstructures of peptidic nanofibrils controlled by conformational memory effect

    Call: OPUS 13 , Panel: ST5

    Principal investigator: prof. Wojciech Dzwolak

    Instytut Wysokich Ciśnień PAN

  34. Interaction of membrane-active peptides with model cell membrane and their role in a drug delivery system. Electrochemic...

    Call: OPUS 12 , Panel: ST4

    Principal investigator: dr Piotr Rafał Pięta

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  35. Structural studies of the impact of gemini surfactants on model amyloidogenic peptides.

    Call: PRELUDIUM 12 , Panel: ST5

    Principal investigator: Julia Maria Ludwiczak

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

  36. Mechanism of substrate recognition and binding by gamma-secretase on the example of the amyloid precursor protein

    Call: PRELUDIUM 12 , Panel: ST4

    Principal investigator: Łukasz Piotr Nierzwicki

    Politechnika Gdańska, Wydział Chemiczny

  37. Study of mechanism of proteolysis and a selective ligand binding to gamma-secretase complex

    Call: OPUS 12 , Panel: NZ2

    Principal investigator: prof. Sławomir Hubert Filipek

    Uniwersytet Warszawski, Wydział Chemii

  38. Identification of Mycobacterium tuberculosis ligands binding human serum amyloid A (SAA) and biological function of tube...

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: dr hab. Bożena Renata Dziadek

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  39. Is interaction with albumin is relevant for metal dependent toxicity of beta-amyloid peptides?

    Call: PRELUDIUM 11 , Panel: NZ1

    Principal investigator: Ewelina Stefaniak

    Instytut Biochemii i Biofizyki PAN

  40. Synthesis and biological evaluation of novel, drug-like multifunctional ligands, as potential anti-Alzheimer's agents ta...

    Call: PRELUDIUM 11 , Panel: NZ7

    Principal investigator: Dawid Marcin Panek

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  41. Multifunctional inhibitors of beta-secretase with anti-aggregating properties of neurotoxic peptides - beta-amyloid and ...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: prof. Barbara Antonina Malawska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  42. Copper induced Ab aggregation upon synaptic excitation. Reaction - diffusion simulations in realistic 3D reconstruction ...

    Call: PRELUDIUM 10 , Panel: NZ1

    Principal investigator: Wojciech Goch

    Instytut Biochemii i Biofizyki PAN

  43. Interactions of amyloid beta peptides with metal ions and lipid membranes: Insights from lattice and all-atom simulation...

    Call: OPUS 10 , Panel: ST4

    Principal investigator: prof. Mai Suan Li

    Instytut Fizyki PAN

  44. Self-aggregation of protein complexes: virus capsids and amyloids

    Call: POLONEZ 1 , Panel: ST3

    Principal investigator: dr Panagiotis Theodorakis

    Instytut Fizyki PAN

  45. New hydrids of tetrahydroacridine derivatives as a acetylocholinesterase with multifunctional activity

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: prof. Paweł Bartosz Szymański

    Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

  46. Conformational transition pathways and molecular mechanisms of aggregation of the amyloidogenic H-fragment of insulin

    Call: OPUS 9 , Panel: NZ1

    Principal investigator: prof. Wojciech Dzwolak

    Uniwersytet Warszawski, Wydział Chemii

  47. Physicochemical and structural aspects of fibrillogenesis modulated by halogeno-chalcone molecules in the presence of li...

    Call: OPUS 9 , Panel: ST4

    Principal investigator: dr Katarzyna Cieślik-Boczula

    Uniwersytet Wrocławski, Wydział Chemii

  48. Influence of neurotoxic factors on aspartate N-acetyltransferase activity in cholinergic neurons

    Call: PRELUDIUM 9 , Panel: NZ3

    Principal investigator: dr Marlena Inga Zyśk

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  49. Abeta 4-x peptides as copper binding molecules resistant to chelating drugs, promoting the formation of amyloid oligomer...

    Call: OPUS 8 , Panel: ST5

    Principal investigator: prof. Wojciech Bal

    Instytut Biochemii i Biofizyki PAN

  50. Search for early molecular mechanisms and markers of preclinical stage of sporadic form of Alzheimer's disease (SAD) in ...

    Call: SONATA 8 , Panel: NZ4

    Principal investigator: dr Anna Mietelska-Porowska

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN