Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The self-assembly of superstructures of peptidic nanofibrils controlled by conformational memory effect

2017/25/B/ST5/02599

Keywords:

Nanofibrils amyloid protein-based nanomaterials insulin superstructures

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Wysokich Ciśnień Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Dzwolak 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 310 000 PLN

Project start date (Y-m-d): 2018-01-24

Project end date (Y-m-d): 2021-12-23

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stacja robocza wieloprocesorowa (CPU / GPU) dedykowana do symulacji MD (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Selective and stoichiometric incorporation of ATP by self-assembling amyloid fibrils
    Authors:
    Robert Dec, Wojciech Puławski, Wojciech Dzwolak
    Academic press:
    Journal of Materials Chemistry B (rok: 2021, tom: 9, strony: 8626–8630), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1TB01976G - link to the publication
  2. Acetone-induced structural variant of insulin amyloid fibrils
    Authors:
    Marcin Guza, Wojciech Dzwolak
    Academic press:
    Journal of Physical Chemistry B , Wydawca: American Chemical Society
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Forced amyloidogenic cooperativity of structurally incompatible peptide segments: Fibrillization behavior of highly aggregation-prone A-chain fragment of insulin coupled to all-L, and alternating L/D octaglutamates
    Authors:
    Robert Dec, Róża Okoń, Wojciech Puławski, Matylda Wacławska, Wojciech Dzwolak
    Academic press:
    International Journal of Biological Macromolecules (rok: 2022, tom: 223, strony: 362-369), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2022.11.050 - link to the publication
  4. Liquid-Droplet-Mediated ATP-Triggered Amyloidogenic Pathway of Insulin-Derived Chimeric Peptides: Unraveling the Microscopic and Molecular Processes
    Authors:
    Robert Dec, Michel Jaworek, Wojciech Dzwolak, Roland Winter
    Academic press:
    Journal of The American Chemical Society (rok: 2023, tom: 145, strony: 4177–4186), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.2c12611 - link to the publication
  5. Virtual Quasi-2D Intermediates as Building Blocks for Plausible Structural Models of Amyloid Fibrils from Proteins with Complex Topologies: A Case Study of Insulin
    Authors:
    Wojciech Puławski, Wojciech Dzwolak
    Academic press:
    Langmuir (rok: 2022, tom: 38, strony: 7024–7034), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.2c00699 - link to the publication
  6. Enzymatic digestion of luminescent albumin-stabilized gold nanoclusters under anaerobic conditions: clues to the quenching mechanism
    Authors:
    Matylda Wacławska, Hanna Nieznańska, Wojciech Dzwolak
    Academic press:
    Journal of Materials Chemistry C (rok: 2022, tom: 10, strony: 3775–3783), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1TC05891F - link to the publication
  7. Revisiting the conformational state of albumin conjugated to gold nanoclusters: A selfassembly pathway to giant superstructures unraveled
    Authors:
    Michał Kluz, Hanna Nieznańska, Robert Dec, Igor Dzięcielewski, Bartosz Niżyński, Grzegorz Ścibisz, Wojciech Puławski, Grzegorz Staszczak, Ewelina Klein, Julita Smalc-Koziorowska, Wojciech Dzwolak
    Academic press:
    PLOS ONE (rok: 2019, tom: 14, strony: e0218975 (1-21)), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0218975 - link to the publication
  8. Self-assembly of insulin-derived chimeric peptides into two-component amyloid fibrils: the role of Coulombic interactions
    Authors:
    Mateusz Fortunka, Robert Dec, Wojciech Puławski, Marcin Guza, Wojciech Dzwolak
    Academic press:
    Journal of Physical Chemistry B (rok: 2023, tom: 127, strony: 6597−6607), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.3c00976 - link to the publication

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