Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Bleomycin hydrolase, homocysteine metabolism, epigenetic regulation of mTOR signalling, autophagy, and Alzheimer's disease

2021/43/B/NZ4/00339

Keywords:

BLMH homocysteine thiolactone Phf8 Alzheimer's disease Blmh-/-3xTg-AD mice mouse neroblastoma cells N2A-APPSwe amyloid beta phospho-Tau

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_11: Metabolism

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Bioinżynierii

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hieronim Jakubowski 

Number of co-investigators in the project: 7

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 3 513 600 PLN

Project start date (Y-m-d): 2022-10-03

Project end date (Y-m-d): 2026-10-02

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine β-synthase-deficient mice
    Authors:
    Witucki Ł, Jakubowski H
    Academic press:
    J Inherit Metab Dis (rok: 2023, tom: 46, strony: 1114-1130), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1002/jimd.12661 - link to the publication
  2. Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 746), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12050746 - link to the publication
  3. Proteomic Exploration of Paraoxonase 1 Function in Health and Disease
    Authors:
    Hieronim Jakubowski
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24, strony: 7764), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24097764 - link to the publication
  4. Homocysteine metabolites inhibit autophagy by upregulating miR‑21‑5p, miR‑155‑5p, miR‑216‑5p, and miR‑320c‑3p in human vascular endothelial cells
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    Scientific Reprts (rok: 2024, tom: 14, strony: 7151), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s441598-024-57750-3 - link to the publication
  5. Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory- and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease.
    Authors:
    Witucki Ł, Borowczyk K, Suszyńska-Zajczyk J, Warzych E, Pawlak E, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (rok: 2023, tom: 95(4), strony: 1735-1755), Wydawca: IOSpress
    Status:
    Published
    DOI:
    10.3233/JAD-230578 - link to the publication

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