Projects funded by the NCN
Potential neuroprotective properties of modulators of sphingosine-1-phosphate (S1P) receptors (fingolimod and siponimod) in toxicity of amyloid beta oligomers: The significance of S1P receptors in Alzheimer's disease
2021/41/N/NZ5/02036
Keywords:
Alzheimer's disease amyloid beta oligomers sphingosine-1-phosphate (S1P) S1P receptors fingolimod siponimod
Descriptors:
- NZ5_007:
- NZ5_003:
- NZ7_014:
Panel:
NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution :
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 20 - announced on 2021-03-15
Amount awarded: 140 000 PLN
Project start date (Y-m-d): 2022-01-21
Project end date (Y-m-d): 2024-01-20
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in NeurodegenerationAuthors:Iga Wieczorek, Robert Piotr StrosznajderAcademic press:Int J Mol Sci (rok: 2023, tom: 24(7), strony: 6180), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms24076180 - link to the publication
- S1P receptor modulators affect the toxicity of amyloid beta oligomers in microglial and neuronal cellsAuthors:Iga Wieczorek, Robert Piotr StrosznajderAcademic press:Folia Neuropathologica (rok: 2024, tom: 62(4), strony: 348-361), Wydawca: TermediaStatus:PublishedDOI:10.5114/fn.2024.145758 - link to the publication