Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Is interaction with albumin is relevant for metal dependent toxicity of beta-amyloid peptides?

2016/21/N/NZ1/02785

Keywords:

beta-amyloid peptides copper albumin oligomers

Descriptors:

  • NZ1_3: Biophysics
  • ST4_3: Molecular architecture and structure
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Ewelina Stefaniak 

Number of co-investigators in the project: 3

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2017-01-12

Project end date (Y-m-d): 2020-01-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Notebook Dell Inspirion 5378.
  2. licencja Origin (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Exploration of the Potential Role for Aβ in Delivery of Extracellular Copper to Ctr1.
    Authors:
    Stefaniak, E.; Pushie, M. J.; Vaerewyck, C.; Corcelli, D.; Griggs, C.; Lewis, W.; Kelley, E.; Maloney, N.; Sendzik, M.; Bal, W.; Haas, K.
    Academic press:
    Inorg. Chem. (rok: 2020, tom: 59,23, strony: 16952-16966), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.0c02100 - link to the publication
  2. The Aggregation Pattern of Aβ1–40 Is Altered by the Presence of N-Truncated Aβ4–40 and/or CuII in a Similar Way through Ionic Interactions
    Authors:
    Stefaniak, E.; Atrian-Blasco, E.; Goch, W.; Sabater, L.; Hureau, C.; Bal, W.
    Academic press:
    Chem. Eur. J. (rok: 2021, tom: 27, strony: 2798), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/chem.202004484 - link to the publication
  3. Copper Transporters? Glutathione Reactivity of Products of Cu–Aβ Digestion by Neprilysin
    Authors:
    Ewelina Stefaniak, Dawid Płonka, Paulina Szczerba, Nina E. Wezynfeld, and Wojciech Bal
    Academic press:
    Inorganic Chemistry (rok: 2020, tom: 59 (7), strony: 4186-4190), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.0c00427 - link to the publication
  4. CuII Binding Properties of N‑Truncated Aβ Peptides: In Search of Biological Function
    Authors:
    Ewelina Stefaniak, Wojciech Bal
    Academic press:
    Inorganic Chemistry (rok: 2019, tom: 58, strony: 13561-13577), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b01399 - link to the publication
  5. Using N‑Terminal Coordination of Cu(II) and Ni(II) to Isolate the Coordination Environment of Cu(I) and Cu(II) Bound to His13 and His14 in Amyloid-β(4−16)
    Authors:
    M. Jake Pushie, Ewelina Stefaniak, Madison R. Sendzik, Dimosthenis Sokaras, Thomas Kroll and Kathryn L. Haas
    Academic press:
    Inorganic Chemistry (rok: 2019, tom: 58, strony: 15138-15154), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b01940 - link to the publication
  6. Hierarchical Binding of Copper II to N-Truncated Aβ 4–16 Peptide.
    Authors:
    Teng, X.; Stefaniak, E.; Girvan, P.; Kotuniak, R.; Płonka, D.; Bal, W.; Ying, L.
    Academic press:
    Metallomics (rok: 2020, tom: 12, strony: 470-473), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9mt00299e - link to the publication
  7. The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(II) from albumin. Implications for copper uptake by Ctr1
    Authors:
    Ewelina Stefaniak, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad, Kathryn L. Haas, M. Jake Pushie, Peter Faller, Nina E. Wezynfeld and Wojciech Bal
    Academic press:
    Metallomics (rok: 2018, tom: 10, strony: 1723), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8mt00274f - link to the publication

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