Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Interaction of membrane-active peptides with model cell membrane and their role in a drug delivery system. Electrochemical, PM IRRAS as well as STM and AFM studies.

2016/23/B/ST4/02791

Keywords:

antimicrobial peptides amyloid peptides beta amyloid LL-37 Alzheimer disease PM IRRAS

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST4_3: Molecular architecture and structure
  • ST5_4: Thin films

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii Fizycznej Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Pięta 

Number of co-investigators in the project: 3

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 108 450 PLN

Project start date (Y-m-d): 2017-08-09

Project end date (Y-m-d): 2021-02-08

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop z oprogramowaniem (12 000 PLN)
  2. Przystawka niskoprądowa.
  3. Naczynko elektrochemiczne do pomiarów PM-IRRAS (160 000 PLN)
  4. Spektrometr FT-IR z wyposażeniem do PM-IRRAS (495 000 PLN)
  5. UVO-cleaner (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Book publications / chapters in book publications (1)
  1. Interaction of LL-37 human cathelicidin peptide with model microbial-like lipid membrane
    Authors:
    Marta Majewska, Vlad Zamlynny, Izabela S. Pieta, Robert Nowakowski, Piotr Pieta
    Academic press:
    Bioelectrochemistry (rok: 2021, tom: 141, strony: 107842), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2021.107842 - link to the publication
  2. Size-Dependent Interaction of Amyloid β Oligomers with Brain Total Lipid Extract Bilayer—Fibrillation Versus Membrane Destruction
    Authors:
    Dusan Mrdenovic, Marta Majewska, Izabela S. Pieta, Piotr Bernatowicz, Robert Nowakowski, Wlodzimierz Kutner, Jacek Lipkowski, Piotr Pieta
    Academic press:
    Langmuir (rok: 2019, tom: 35, strony: 11940-11949), Wydawca: ACS Publication
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.9b01645 - link to the publication
  3. Alzheimer's disease-related amyloid beta peptide causes structural disordering of lipids and changes the electric properties of a floating bilayer lipid membrane
    Authors:
    D. Mrdenovic, Z. Su, W. Kutner, J. Lipkowski, P. Pieta
    Academic press:
    Nanoscale Advances (rok: 2020, tom: 2, strony: 3467-3480), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D0NA00292E - link to the publication
  4. Amyloid β interaction with model cell membranes – What are the toxicity-defining properties of amyloid β?
    Authors:
    D. Mrdenovic, I. S. Pieta, R. Nowakowski, W. Kutner, J. Lipkowski, P. Pieta
    Academic press:
    Internationa Journal of Biological Macromolecules (rok: 2022, tom: 200, strony: 520-531), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2022.01.117 - link to the publication
  5. Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162
    Authors:
    D. Mrdenovic, P. Zarzycki, M. Majewska, I. S. Pieta, R. Nowakowski, W. Kutner, J. Lipkowski, P. Pieta
    Academic press:
    ACS Chem. Neurosci. (rok: 2021, tom: 12, strony: 531-541), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acschemneuro.0c00754 - link to the publication
  6. Nanomechanical characterization of single phospholipid bilayer in ripple phase with PF-QNM AFM
    Authors:
    M. Majewska, D. Mrdenovic, I. S. Pieta, R. Nowakowski, P. Pieta
    Academic press:
    Biochim. et Biophys. Acta – Biomembranes (rok: 2020, tom: 1862, strony: 183347), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2020.183347 - link to the publication
  7. Toxicity of selected airborne nitrophenols on eukaryotic cell membrane models
    Authors:
    M. Majewska, F. Khan, I. S. Pieta, A. Wróblewska, R. Szmigielski, P. Pieta
    Academic press:
    Chemosphere (rok: 2021, tom: 266, strony: 128996), Wydawca: Elsever
    Status:
    Published
    DOI:
    10.1016/j.chemosphere.2020.128996 - link to the publication
  1. Analysis of early-stage toxic properties of amyloid β oligomers by atomic force microscopy
    Authors:
    D. Mrdenovic, J. Lipkowski, P. Pieta
    Book:
    Membrane Lipids in Methods in Molecular Biology (rok: 2022, tom: 2402, strony: 227-241), Wydawca: Humana, New York, NY
    Status:
    Published

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