Projects funded by the NCN
New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer's disease
2020/37/N/NZ7/01081
Keywords:
multifunctional ligands Alzheimer's disease drug-like properties butyrylcholinesterase tau protein amyloid organic synthesis
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Collegium Medicum
woj.
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 19 - announced on 2020-03-16
Amount awarded: 69 360 PLN
Project start date (Y-m-d): 2021-01-18
Project end date (Y-m-d): 2023-01-17
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer's diseaseAuthors:Anna Pasieka, Dawid Panek, Paula Zaręba, Emilia Sługocka, Natalia Gucwa, Alba Espargaro, Gniewomir Latacz, Nadia Khan, Adam Bucki, Raimon Sabate, Anna Więckowska, Barbara MalawskaAcademic press:Bioorganic & Medicinal Chemistry (rok: 2023, tom: 88-89, strony: 117333), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bmc.2023.117333 - link to the publication