Projects funded by the NCN

Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr Tomasz Prajsnar

Uniwersytet Jagielloński, Wydział Biologii

Actin cytoskeleton disorders as a pro-survival signaling activator and a therapeutic biomarker in Diffuse Large B-cell L...

Call: SONATA BIS 13 , Panel: NZ5

Principal investigator: dr Patryk Górniak

Instytut Hematologii i Transfuzjologii

Modulation of Gi/0 activity by disulfiram as the mechanism preventing tolerance development to the antinociceptive actio...

Call: SONATA BIS 13 , Panel: NZ3

Principal investigator: dr hab. Anna Leśniak

Warszawski Uniwersytet Medyczny

Determination of the molecular mechanism of action of TRIM32 E3 ligase in the regulation of adipocytes' function

Call: PRELUDIUM 22 , Panel: NZ4

Principal investigator: Katia Alghoz

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

The effects of myopathy-causing mutations in TPM2 on tropomyosin-dependent regulation of the thin filament length

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Recep Küçükdoğru

Uniwersytet Kazimierza Wielkiego

Combining microfluidic-assisted biofabrication with high throughput proteomics to unravel skeletal muscle plasticity und...

Call: SONATINA 7 , Panel: ST5

Principal investigator: dr Nehar Celikkin

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Mechanism of action of b-cyclocitral and its derivative in inducing flax resistance to Fusarium oxysporum infection

Call: OPUS 24 , Panel: NZ9

Principal investigator: dr Aleksandra Boba

Uniwersytet Wrocławski, Wydział Biotechnologii

Searching for new chemical compounds inducing resistance of apple to diseases and determination of the molecular mechani...

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Artur Mikiciński

Instytut Ogrodnictwa - Państwowy Instytut Badawczy

Exploring the anticancer, antibacterial and antifungal potential and underlying mechanism of action of plants used in Po...

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Kamila Rachwał

Uniwersytet Przyrodniczy w Lublinie

The role of GPR39 receptor in the mechanism of antidepressant action

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr Katarzyna Młyniec

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Mechanisms of cyclization reactions leading to biologically active compounds catalyzed by iron dependent enzymes.

Call: OPUS 23 , Panel: ST4

Principal investigator: prof. Tomasz Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera Polskiej Akademii Nauk

How saccadic eye movements influence auditory perception: their role for audition and neural mechanisms.

Call: OPUS 23 , Panel: HS6

Principal investigator: dr Marcin Leszczyński

Uniwersytet Jagielloński, Wydział Filozoficzny

Two-dimensional MBene materials as novel photocatalysts for the removal of pharmaceuticals from wastewaters

Call: PRELUDIUM 21 , Panel: ST5

Principal investigator: Dominika Bury

Politechnika Warszawska, Wydział Inżynierii Materiałowej

Tropomyosin isoform Tpm2.3 in regulation of actin dynamics and osteosarcoma metastasis

Call: WEAVE-UNISONO , Panel: NZ5

Principal investigator: prof. Joanna Moraczewska

Uniwersytet Kazimierza Wielkiego w Bydgoszczy

The mechanism of action of pesticides and their impact on rooster's fertility

Call: OPUS 22 , Panel: NZ9

Principal investigator: dr hab. Agnieszka Partyka

Uniwersytet Przyrodniczy we Wrocławiu

Ugly, Dirty and Bad? - the quest for the mechanisms of antioxidant action ofsome nitrogen and sulfur compounds.

Call: OPUS 22 , Panel: ST4

Principal investigator: prof. Grzegorz Litwinienko

Uniwersytet Warszawski, Wydział Chemii

Adaptation of mitochondrial functions to stress caused by plastic dust/pollution; action of mitochondrial retrograde sig...

Call: OPUS 22 , Panel: NZ5

Principal investigator: prof. Joanna Szczepanowska

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Dual 5-HT3 receptor/5-HT6 receptor antagonists in neuropsychiatric and neurological disorders

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Paweł Zajdel

Uniwersytet Jagielloński, Collegium Medicum

Tailoring multicomponent nanometric alloys formed on active support for designing the stable anodes of Solid Oxide Fuel ...

Call: SONATA BIS 11 , Panel: ST5

Principal investigator: dr hab. Beata Bochentyn

Politechnika Gdańska

Diamond and graphite nanoparticles as an antitumor agents - characteristics of antinutritional mechanism of action on an...

Call: PRELUDIUM 2 , Panel: NZ9

Principal investigator: dr Mateusz Wierzbicki

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Nauk o Zwierzętach, Katedra Żywienia Zwierząt i Gospodarki Paszowej

CONTROLLED CRAZING IN BIOPOLYMER SYSTEMS: THE ROLE OF ACTIVE LIQUID ENVIRONMENTS, POLYMER MORPHOLOGY AND CHEMICAL STRUCT...

Call: PRELUDIUM 20 , Panel: ST5

Principal investigator: Ramin Hosseinnezhad

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Research of the mechanism of microbial membrane disorders caused by the presence of copper as an effective antibacterial...

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Agata Ładniak

Katolicki Uniwersytet Lubelski Jana Pawła II

Mitochondria-targeting conjugates as a new anticancer agents

Call: OPUS 21 , Panel: ST4

Principal investigator: prof. Adam Huczyński

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Chemical composition, antioxidant properties and related molecular mechanisms of action of matcha green tea extracts - i...

Call: PRELUDIUM 20 , Panel: NZ9

Principal investigator: Joanna Kochman

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Nauk o Zdrowiu

The impact and mechanism of action of the lactoperoxidase system modified by using non-physiological substrates on cario...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Marcin Magacz

Uniwersytet Jagielloński, Collegium Medicum

A new class of antimicrobial compounds. Design, synthesis and study of the mechanism of action.

Call: PRELUDIUM BIS 2 , Panel: NZ7

Principal investigator: dr hab. Sylwia Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Combined experimental and theoretical studies of the catalytic activity of RPE65 enzyme using biomimetic active centre m...

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Adam Kubas

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Comparison of the mechanism of action of valproic acid and levetiracetam as histone deacetylase inhibitors in ovarian ca...

Call: PRELUDIUM 2 , Panel: NZ7

Principal investigator: Patrycja Kwiecińska

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

Conditional factors of processes and mechanism of interaction between vision for perception and vision for action in rel...

Call: OPUS 2 , Panel: HS6

Principal investigator: dr Piotr Styrkowiec

Uniwersytet Wrocławski, Wydział Nauk Historycznych i Pedagogicznych

Clinical effect and molecular mechanisms of action of s-adenosylmethionine (SAMe) in patients with primary sclerosing ch...

Call: PRELUDIUM BIS 2 , Panel: NZ5

Principal investigator: prof. Piotr Milkiewicz

Warszawski Uniwersytet Medyczny

Uracil in DNA and aberrant DNA methylation/hydroxymethylation as a new biomarkers of multiple myeloma development? A sea...

Call: OPUS 20 , Panel: NZ5

Principal investigator: prof. Ryszard Oliński

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr Natalia Małek-Chudzik

Politechnika Wrocławska

In vivo and ex vivo tracking the cocaine's mechanism of action in the medial part of the central amygdala

Call: PRELUDIUM 19 , Panel: NZ4

Principal investigator: Łukasz Bijoch

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Determination of the mechanisms responsible for the mobility of non-integrin laminin receptor (LamR) isoforms, including...

Call: PRELUDIUM 19 , Panel: NZ1

Principal investigator: Ewa Mazurkiewicz

Uniwersytet Wrocławski, Wydział Biotechnologii

Understanding the molecular mechanism of toxic action of the most dangerous trichothecene - T-2 toxin

Call: PRELUDIUM 19 , Panel: NZ9

Principal investigator: Edyta Janik

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Novel therapy for pulmonary hypertension with dual mechanism of action: Myo-inositol trispyrophosphate targeting both pu...

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Michał Mączewski

Centrum Medyczne Kształcenia Podyplomowego

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

In vivo effects, underlying signaling pathways and mechanism of action of ghrelin receptor agonist against pathological ...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Piotr Chmielarz

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Gamma-glutamylcysteine ligase participation in the antioxidant mechanism of action of sulodexide on vascular endothelial...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Klaudia Bontor

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

Transformer-based methods for novel active chemical compounds

Call: PRELUDIUM 18 , Panel: ST6

Principal investigator: Łukasz Maziarka

Uniwersytet Jagielloński, Wydział Matematyki i Informatyki

Probiotics and prebiotics- their effect on the chicken intestine health and organism performance, from the pre-hatch per...

Call: OPUS 18 , Panel: NZ9

Principal investigator: dr hab. Katarzyna Stadnicka

Uniwersytet Technologiczno-Przyrodniczy im. Jana i Jędrzeja Śniadeckich w Bydgoszczy, Wydział Hodowli i Biologii Zwierząt

Evaluation of molecular mechanisms of neuroprotective action of dental pulp stromal cells in an ex vivo organotypic mode...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Natalia Bryniarska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Toxicological features of new two-dimensional nanomaterials from the MBenes family

Call: OPUS 18 , Panel: ST5

Principal investigator: dr hab. Agnieszka Jastrzębska

Politechnika Warszawska, Wydział Inżynierii Materiałowej

Dual action of HBK-15 – unraveling cellular mechanisms underlying its fast antidepressant-like and procognitive effects...

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Karolina Pytka

Uniwersytet Jagielloński, Collegium Medicum

Synthesis and biochemical properties of sulfonamide antibiotic derivatives together with analyses of changes in their bi...

Call: OPUS 17 , Panel: ST4

Principal investigator: prof. Mariusz Makowski

Uniwersytet Gdański, Wydział Chemii

Specific interactions of new antitumor unsymmetrical bisacridines, UAs, with DNA and ABC proteins and their potential to...

Call: OPUS 17 , Panel: NZ7

Principal investigator: prof. Zofia Mazerska

Politechnika Gdańska

Investigation of parabens' estrogen-like mechanism of action in the context of assessment its influence on the functions...

Call: PRELUDIUM 16 , Panel: NZ7

Principal investigator: Karolina Nowak

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Dual action mode inhibitors of urease and their anti-virulent activity against Helicobacter pylori and Cryptococcus neof...

Call: OPUS 16 , Panel: NZ6

Principal investigator: prof. Artur Mucha

Politechnika Wrocławska

Physico-chemical principles of antioxidant action: from solvent effect and mechanistic studies to interfacial phenomena ...

Call: OPUS 16 , Panel: ST4

Principal investigator: prof. Grzegorz Litwinienko

Uniwersytet Warszawski, Wydział Chemii

The anti-inflammatory effect of vitamin K - Mechanism of action

Call: PRELUDIUM 16 , Panel: NZ7

Principal investigator: dr Anna Kierońska-Rudek

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)