Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resistant depression

2015/17/B/NZ7/02979

Keywords:

Deep brain stimulation antidepressant drugs treatment-resistant depression animal models Wistar rats Wistar-Kyoto rats chronic stress anhedonia cognitive impairment stress hormones BDNF glutamate receptors gene expression protein levels gene screening

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Papp 

Number of co-investigators in the project: 7

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 716 664 PLN

Project start date (Y-m-d): 2016-02-26

Project end date (Y-m-d): 2019-02-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stolik stereotaktyczny z oprzyrządowaniem (25 745 PLN)
  2. Stymulator wielokanałowy i Konwerter cyfrowo-analogowy (33 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. VALIDATION OF CHRONIC MILD STRESS IN THE WISTAR-KYOTO RAT AS AN ANIMAL MODEL OF TREATMENT-RESISTANT DEPRESSION
    Authors:
    Paul Willner, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Katarzyna Tota-Glowczyk, Monika Niemczyk and Mariusz Papp
    Academic press:
    Behavioural Pharmacology (rok: 2019, tom: 30, strony: 239-250), Wydawca: Lippincott Williams & Wilkins
    Status:
    Published
    DOI:
    10.1097/FBP.0000000000000431 - link to the publication
  2. MOLEKULARNE MARKERY ODPOWIEDZI NA STRES W DWÓCH MODELACH DEPRESJI LEKOOPORNEJ U SZCZURÓW
    Authors:
    Agata Faron-Górecka, Maciej Kusmider, Mariusz Papp
    Academic press:
    Strona popularnonaukowa IF PAN (rok: 2018, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Instytut Farmakologii PAN w Krakowie
    Status:
    Published
    DOI:
    brak - link to the publication
  3. RAPID ANTIDEPRESSANT EFFECTS OF DEEP BRAIN STIMULATION OF THE PRE-FRONTAL CORTEX IN AN ANIMAL MODEL OF TREATMENT-RESISTANT DEPRESSION
    Authors:
    Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Katarzyna Tota-Glowczyk, Monika Niemczyk and Paul Willner
    Academic press:
    Journal of Psychopharmacology (rok: 2018, tom: 32, strony: 1133-1140), Wydawca: SAGE Publishing
    Status:
    Published
    DOI:
    10.1177/0269881118791737 - link to the publication
  4. GENOMIC SCREENING OF WISTAR AND WISTAR-KYOTO RATS EXPOSED TO CHRONIC MILD STRESS AND DEEP BRAIN STIMULATION OF THE PREFRONTAL CORTEX
    Authors:
    Mariusz Papp, Piotr Gruca, Agata Faron-Górecka, Maciej Kusmider and Paul Willner
    Academic press:
    Neuroscience 423 (2019) 66–75 (rok: 2019, tom: 423, strony: 66–75), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.015 - link to the publication
  1. Antidepressant efficacy of Deep Brain Stimulation in Wistar Kyoto rats exposed to Chronic Mild Stress: an animal model of treatment-resistant depression
    Authors:
    Gruca P, Papp M, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P
    Conference:
    31st Congress of the European College of Neuropsychopharmacology (ECNP) (rok: 2018, ), Wydawca: Elsevier
    Data:
    konferencja 6 - 9 październik
    Status:
    Published
  2. Brain Stimulation of the medial prefrontal cortex has anxiolytic and pro-cognitive effects in two animal models of treatment-resistant depression in rats
    Authors:
    Papp M, Gruca P, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P.
    Conference:
    17th Biennial Meeting of the European Behavioural Pharmacology Society (rok: 2017, ), Wydawca: Lippincott Williams & Wilkins
    Data:
    konferencja 31 sierpnia - 3 września
    Status:
    Published
  3. Changes in genes expression correlate with stress and deep brain stimulation in two strains of rats.
    Authors:
    Kuśmider M, Faron-Górecka A, Dziedzicka-Wasylewska M, Papp M
    Conference:
    Workshop: Cognitive affective biases - from mechanisms to disease symptoms (rok: 2019, ), Wydawca: Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Data:
    konferencja 13 - 17 maj
    Status:
    Published
  4. Effects of deep brain stimulation of the medial prefrontal cortex in two animal models of treatment-resistant depression.
    Authors:
    Gruca P, Papp M, Lason-Tyburkiewicz M, Litwa E, Niemczyk M, Tota-Glowczyk K, Willner P
    Conference:
    30th Congress of the European College of Neuropsychopharmacology (ECNP), Paris 2017 (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja 2 - 5 września
    Status:
    Published

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