Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of endoplasmic reticulum stress in the pathomechanisms of early-life stress-induced dysfunction of the prefronatal cortex and in the mechanisms of action of fluoxetine in children and adolescents

2017/25/B/NZ7/00174

Keywords:

early-life stress maternal separation endoplasmic reticulum stress unfolded-protein response (UPR) prefrontal cortex fluoxetine mood disorders anxiety adolescence

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ4_7: Neurophysiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Chocyk 

Number of co-investigators in the project: 4

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 953 280 PLN

Project start date (Y-m-d): 2018-01-03

Project end date (Y-m-d): 2022-01-02

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do elektroforezy i immunoblottingu białek (4-ro żelowy) zawierający zasilacz i moduł do polimeryzacji żeli (13 265 PLN)
  2. Zamrażarka laboratoryjna (-18º do -30º) (3 000 PLN)
  3. Komputer.
  4. Podstawowe oprogramowanie komputerowe w tym pakiet biurowy (office) (2 000 PLN)
  5. Szafa termostatyczna z wentylają (9 000 PLN)
  6. Wytrząsarka orbitalna (3 500 PLN)
  7. Komputer (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. A Search for Biomarkers of Early-life Stress-related Psychopathology: Focus on 70-kDa Heat Shock Proteins
    Authors:
    Anna Solarz, Iwona Majcher-Maślanka, Joanna Kryst, Agnieszka Chocyk
    Academic press:
    Neuroscience (rok: 2021, tom: 463, strony: 238-253), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2021.02.026 - link to the publication
  2. Maternal Separation Disturbs Postnatal Development of the Medial Prefrontal Cortex and Affects the Number of Neurons and Glial Cells in Adolescent Rats
    Authors:
    Iwona Majcher-Maślanka, Anna Solarz, Agnieszka Chocyk
    Academic press:
    Neuroscience (rok: 2019, tom: 423, strony: 131-147), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.033 - link to the publication
  1. A search for a role of endoplasmic reticulum stress and unfolded protein response in the mechanisms of susceptibility or resilience to early-life stress in rats
    Authors:
    Agnieszka Chocyk, Iwona Majcher-Maślanka, Anna Solarz, Joanna Kryst
    Conference:
    FENS 2020 Virtual Forum (rok: 2020, ), Wydawca: FENS
    Data:
    konferencja 13-15 lipiec 2020
    Status:
    Published
  2. Early-life stress affects the numbers and apoptosis of neurons and glia cells during postnatal development of the medial prefrontal cortex in rats
    Authors:
    Iwona Majcher-Maślanka, Anna Solarz, Agnieszka Chocyk
    Conference:
    XIV European Meeting on Glial Cells in Health and Disease Porto, Portugalia (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 10-13 lipiec 2019
    Status:
    Published

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