Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial prefrontal cortex in an animal model of treatment-resistant depression

2017/25/B/NZ7/02710

Keywords:

Deep Brain stimulation optogenetics antidepressant drugs animal models Wistar rats Wistar-Kyoto reats chronic mild stress anhedonia anxiety cognitive deficits dopamine autoradiography immunohistochemistry

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Papp 

Number of co-investigators in the project: 10

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 062 680 PLN

Project start date (Y-m-d): 2018-02-06

Project end date (Y-m-d): 2021-02-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop Toshiba Satelite do obsługi zestawu laserów.
  2. Pompa do perfuzji.
  3. Zestaw źródeł laseru wraz z niezbędnym oprzyrządowaniem (Doric Lenses, Kanada; ThorLabs, Germany) (309 200 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (3)
  1. AMPA RECEPTORS MEDIATE THE PRO-COGNITIVE EFFECTS OF ELECTRICAL AND OPTOGENETIC STIMULATION OF MEDIAL PREFRONTAL CORTEX IN ANTIDEPRESSANT NON-RESPONSIVE WISTAR-KYOTO RATS
    Authors:
    Papp M, Gruca P, Lason M, Litwa E, Solecki W, Willner P
    Academic press:
    Neuropsychopharmacology (rok: 2020, tom: 34, strony: 1418-1430), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1177/0269881120967857 - link to the publication
  2. The role of prefrontal cortex dopamine D2 and D3 receptors in the mechanism of action of venlafaxine and deep brain stimulation in animal models of treatment-responsive and treatment-resistant depression
    Authors:
    Mariusz Papp, Piotr Gruca, Magdalena Lason, Monika Niemczyk and Paul Willner
    Academic press:
    Journal of Psychopharmacology (rok: 2019, tom: 33, strony: 748-756), Wydawca: SAGE PUBLICATIONS LTD
    Status:
    Published
    DOI:
    10.1177/0269881119827889 - link to the publication
  3. INSUFFICIENCY OF VENTRAL HIPPOCAMPUS TO MEDIAL PREFRONTAL CORTEX TRANSMISSION EXPLAINS ANTIDEPRESSANT NON-RESPONSE
    Authors:
    Mariusz Papp, Piotr Gruca, Magdalena Lason, Ewa Litwa, Wojciech Solecki and Paul Willner
    Academic press:
    Journal of Psychopharmacology (rok: 2021, tom: Online, strony: Online ahead of print.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1177/02698811211048281 - link to the publication
  4. Perspectives for therapy of treatment-resistant depression
    Authors:
    Mariusz Papp, Wiesław Jerzy Cubala, Lukasz Swiecicki, Adrian Newman-Tancredi and Paul Willner
    Academic press:
    British Journal of Pharmacology (rok: 2021, tom: Online, strony: Online ahead of print), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/bph.15596 - link to the publication
  1. Antidepressant efficacy of Deep Brain Stimulation in two animal models of treatment-resistant depression.
    Authors:
    Papp M
    Conference:
    XX Międzynarodowy Zjazd Polskiego Towarzystwa Farmakologicznego (rok: 2019, ), Wydawca: xxx
    Data:
    konferencja 5-7 czerwiec
    Status:
    Published
  2. Dopamine receptors in prefrontal cortex mediate effects of venlafaxine, but not DBS, in animal models of treatment-responsive and treatment-resistant depression
    Authors:
    P. Gruca, M. Papp, M. Lason, M. Niemczyk, E. Litwa, P. Willner
    Conference:
    32nd ECNP Congress in Copenhagen (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 7 - 10 września
    Status:
    Published
  3. The role of dopamine and AMPA receptors in prefrontal cortex in mechanisms of action of venlafaxine and deep brain stimulation in animal models of depression
    Authors:
    P. Gruca, M. Papp, M. Lason, M. Niemczyk, E. Litwa, P. Willner
    Conference:
    48th EBBS Meeting in Prague (rok: 2019, ), Wydawca: Lippincott Williams & Wilkins
    Data:
    konferencja 21 - 24 września
    Status:
    Published

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