Projects funded by the NCN

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Information of the project and the call

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Role of the NLRP3 inflammasome in the mechanisms of action of antidepressant drugs - study in an animal model of depression

2015/17/N/NZ7/00924

Keywords:

depression inflammasome NLRP3 primary microglia cultures

Descriptors:

  • NZ6_3: Animal immunology
  • NZ5_3: Pathogenesis of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Trojan 

Number of co-investigators in the project: 3

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 149 784 PLN

Project start date (Y-m-d): 2016-03-24

Project end date (Y-m-d): 2020-03-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (10)
  1. Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures
    Authors:
    Ślusarczyk J, Trojan E, Głombik K, Piotrowska A, Budziszewska B, Kubera M, Popiołek-Barczyk K, Lasoń W, Mika J, Basta-Kaim A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 18, strony: 23), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19071965. - link to the publication
  2. Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway.
    Authors:
    Trojan Ewa, Chamera Katarzyna, Bryniarska Natalia, Kotarska Katarzyna, Leśkiewicz Monika, Regulska Magda, Basta-Kaim Agnieszka
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 56, strony: 5365-5380), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1458-1. - link to the publication
  1. AC-YVAD-CMK prevents NLRP3 inflammasome activation and pyroptosis in animal model of depression.
    Authors:
    Ewa Trojan, Anna Kurek, Katarzyna Chamera, Natalia Bryniasrka, Magda Szuster, Martyna Strzelec, Agnieszka Basta-Kaim
    Conference:
    XIV European Meeting on Glial Cells in Health and Disease (rok: 2019, ), Wydawca: Glia
    Data:
    konferencja 10-13.07.2019
    Status:
    Published
  2. Effect of desipramine treatment in lipopolysaccharide (LPS)- stimulated microglial cells
    Authors:
    Ewa Trojan, Katarzyna Chamera, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    4th International Conference of Cell Biology (ICCB) (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 11-12.05.201 8
    Status:
    Published
  3. THE IMPACT OF FLUOXETINE ON THE ACTIVITY OF PRIMARY MICROGLIAL CULTURES – STUDY IN AN ANIMAL MODEL OF DEPRESSION
    Authors:
    Ewa Trojan, Joanna Slusarczyk, Katarzyna Chamera, Anna Kurek, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    XI Copernican International Young Scientists Conference (rok: 2017, ), Wydawca: Faculty of Chemistry NCU in Toruń, Poland
    Data:
    konferencja 28-30.06.2017
    Status:
    Published
  4. The effect of chronic tianeptine administration on NLRP3 inflammasome pathway – study in an animal model of depression.
    Authors:
    Ewa Trojan, Anna Kurek, Katarzyna Chamera, Joanna Slusarczyk, Katarzyna Głombik, Katarzyna Kotarska, Agnieszka Basta-Kaim
    Conference:
    19th European Congress of Endocrinology (rok: 2017, ), Wydawca: Endocrine Abstracts
    Data:
    konferencja 20-23.05.2017
    Status:
    Published
  5. Effect of reboxetine treatment in lipopolysaccharide (LPS)- stimulated microglial cells
    Authors:
    Trojan E., Chamera K., Bryniarska N., Basta-Kaim A.
    Conference:
    3rd Central European Biomedical Congress News on biomarker discovery and research innovations in medicine and biomedical sciences" (rok: 2018, ), Wydawca: Institute of Pharmacology Polish Academy of Sciences in Cracow, Faculty of Medicine Jagiellonian University Medical College
    Data:
    konferencja 15-18.09.201 8
    Status:
    Published
  6. THE EFFECT OF TIANEPTINE ADMINISTARTION ON NLRP3 INFLAMMASOME ACTIVATION IN PRIMARY MICROGLIAL CULTURES
    Authors:
    E. Trojan, K. Chamera, K. Głombik, K. Kotarska, N. Bryniarska, A. Basta-Kaim
    Conference:
    XLVth Winter School of Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University in Kraków Signaling – from molecules to cells and back" (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 9-14.02.2018
    Status:
    Published
  7. Wpływ leku przeciwdepresyjnego – tianeptyny – na ekspresję podjednostek inflammasomu NLRP3 w pierwotnych hodowlach mikrogleju – badania w zwierzęcym modelu depresji
    Authors:
    E. Trojan, K. Chamera, K. Kotarska, N. Bryniarska, A. Basta-Kaim
    Conference:
    X Interdyscyplinarna konferencja naukowa TYGIEL: Interdyscyplinarność kluczem do rozwoju" (rok: 2018, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 17-18.03.201 8
    Status:
    Published
  8. The influence of reboxetine on inflammatory response mediated by the NLRP3/caspase-1/IL-1β axis in primary microglial cultures
    Authors:
    Martyna Strzelec, Ewa Trojan, Katarzyna Chamera, Magda Szuster, Natalia Bryniarska, Agnieszka Basta-Kaim
    Conference:
    5th International Conference of Cell Biology (ICCB) (rok: 2019, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 10-12.05.2019
    Status:
    Published
  9. The influence of tianeptine on the activity of primary microglial cultures
    Authors:
    Ewa Trojan, Katarzyna Chamera, Katarzyna Kotarska, Natalia Bryniarska, Agnieszka Basta-Kaim
    Conference:
    Neuronus IBRO Neuroscience Forum (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 20-22.04.201 8
    Status:
    Published
  10. THE IMPACT OF PRENATAL STRESS AND VENLAFAXINE TREATMENT ON THE BRAIN INFLAMMASOME NLRP3 PATHWAY
    Authors:
    Ewa Trojan, Katarzyna Chamera, Agnieszka Basta-Kaim
    Conference:
    13th EFIS-EJI Tatra Immunology Conference (rok: 2018, ), Wydawca: European Federation of Immunological Societies, European Journal of Immunology
    Data:
    konferencja 9-13.06.2018
    Status:
    Published

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