Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Old drugs - new perspectives: modulation of antibiotics activity by caffeine and pentoxifylline

2016/21/D/NZ7/01524

Keywords:

caffeine antibiotic bacteria antibacterial activity stacking interactions drug resistance synergism antagonism combination therapy mechanism of action virulence

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ1_3: Biophysics
  • NZ6_4: Bacteriology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Woziwodzka 

Number of co-investigators in the project: 4

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 464 600 PLN

Project start date (Y-m-d): 2017-01-24

Project end date (Y-m-d): 2022-01-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cieplarka do hodowli mikroorganizmów (8 000 PLN)
  2. Komputer z oprogramowaniem specjalistycznym (m.in. Sigma Plot, MathCad, Statistica) (5 000 PLN)
  3. Spektrofotometr UV-VIS (50 000 PLN)
  4. Termoblok z wytrząsaniem (7 000 PLN)
  5. Cieplarka z wytrząsaniem do hodowli mikroorganizmów (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Modulatory Effects of Caffeine and Pentoxifylline on Aromatic Antibiotics: A Role for Hetero-Complex Formation
    Authors:
    Anna Woziwodzka, Marta Krychowiak-Maśnicka, Grzegorz Gołuński, Anna Felberg, Agnieszka Borowik, Dariusz Wyrzykowski, Jacek Piosik
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 3628), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26123628 - link to the publication
  2. New life of an old drug: caffeine as a modulator of antibacterial activity of commonly used antibiotics
    Authors:
    Anna Woziwodzka, Marta Krychowiak-Maśnicka, Grzegorz Gołuński, Anna Łosiewska, Agnieszka Borowik, Dariusz Wyrzykowski, Jacek Piosik
    Academic press:
    Pharmaceuticals (rok: 2022, tom: -, strony: Manuscript ID: pharmaceuticals-1798279), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15070872 - link to the publication
  1. Noncovalent complex formation of Pseudomonas aeruginosa essential virulence factor pyocyanin with caffeine and its biological implications
    Authors:
    Anna Woziwodzka, Agata Woźniak, Aleksandra Rapacka-Zdończyk, Marta Krychowiak-Maśnicka, Dariusz Wyrzykowski, Jacek Piosik
    Conference:
    13th EBSA congress (rok: 2021, ), Wydawca: European Biophysics Journal/Springer Nature
    Data:
    konferencja 24-28.07.2021
    Status:
    Published
  2. Caffeine binds to antibiotics ciprofloxacin and tetracycline and alters their antibacterial activity
    Authors:
    Anna Woziwodzka, Anna Felberg, Ziemowit Kornas, Agnieszka Borowik, Grzegorz Gołuński, Jacek Piosik
    Conference:
    19th IUPAB Congress and 11th European Biophysics Congress (rok: 2017, ), Wydawca: European Biophysics Journal/Springer Nature
    Data:
    konferencja 16-20.07.2017
    Status:
    Published

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