Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The mechanism of neurotoxic action of benzophenone-3

2014/15/B/NZ7/00892

Keywords:

benzophenone-3 neurotoxicity apoptosis glutamate activation of microglia sex hormone receptors and aryl hydrocarbon receptor

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_7: Signal transduction
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bogusława Budziszewska 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 997 200 PLN

Project start date (Y-m-d): 2015-07-13

Project end date (Y-m-d): 2018-07-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termocykler RT-PCR (120 000 PLN)
  2. Stolik stereotaktyczny dla szczurów (30 000 PLN)
  3. aparat do pomiaru stężenia i czystości DNA/RNA.
  4. Ramiona do przeprowadzenia mikrodializy na wolnoporuszających się zwierzętach (18 450 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (5)
  1. Effect of combined prenatal and adult benzophenone-3 dermal exposure on factors regulating neurodegenerative processes, blood hormone levels, and hematological parameters in female rats
    Authors:
    Skórkowska A., Maciejska A., Pomierny B., Krzyżanowska W., Starek-Świechowicz B., Bystrowska B., Broniowska Ż., Kazek G., Budziszewska B.
    Academic press:
    Neurotoxicity Research (rok: 2020, ), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s12640-020-00163-7 - link to the publication
  2. Benzophenone-3 passes through the blood-brain barrier, increases the level of extracellular glutamate, and induces apoptotic processes in the hippocampus and frontal cortex of rats
    Authors:
    Pomierny B., Krzyżanowska W., Broniowska Ż., Strach B., Bystrowska B., Starek-Świechowicz B., Maciejska A., Skórkowska A., Wesołowska J., Walczak M., Budziszewska B.
    Academic press:
    Toxicological Sciences (rok: 2019, tom: 171, strony: 485-500), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/toxsci/kfz160 - link to the publication
  3. The effects of benzophenone-3 on apoptosis and the expression of sex hormone receptors in the frontal cortex and hippocampus of rats
    Authors:
    Krzyżanowska W., Pomierny B., Starek-Świechowicz B., Broniowska Ż., Strach B., Budziszewska B.
    Academic press:
    Toxicology Letters (rok: 2018, tom: 296, strony: 63-72), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2018.08.006 - link to the publication
  1. Mechanizm neurotoksycznego działania benzofenonu-3
    Authors:
    Weronika Krzyżanowska, Beata Starek-Świechowicz, Żaneta Broniowska, Bartosz Pomierny, Beata Bystrowska, Bogusława Budziszewska
    Conference:
    Różne oblicza Toksykologii (rok: 2017, ), Wydawca: Polskie Towarzystwo Toksykologiczne
    Data:
    konferencja 19-22 wrzesień 2017
    Status:
    Published
  2. Benzophenone-3 concentration and its effect on oxidative stress markers in rat brain
    Authors:
    Bogusława Budziszewska, Żaneta Broniowska, Bartosz Pomierny, Beata Starek-Świechowicz, Weronika Krzyżanowska, Beata Bystrowska, Beata Strach
    Conference:
    18th World Kongress of Basic and Clinical Pharmacology (rok: 2018, ), Wydawca: Japanese Pharmcological Society
    Data:
    konferencja 01.07-06.07. 2018
    Status:
    Published
    DOI:
    link to the publication
  3. Benzophenone-3 affects glutaminergic system in the rat brain.
    Authors:
    Weronika Krzyżanowska, Bartosz Pomierny, Beata Starek-Świechowicz, Żaneta Broniowska, Beata Strach, Beata Bystrowska, Bogusława Budziszewska
    Conference:
    18th World Kongress of Basic and Clinical Pharmacology (rok: 2018, ), Wydawca: Japanese Pharmcological Society
    Data:
    konferencja 01.07-06.07. 2018
    Status:
    Published
  4. Benzophenone-3 and its proapoptotic activity in the rat brain
    Authors:
    Bartosz Pomierny, Weronika Krzyżanowska, Beata Strach, Beata Starek-Świechowicz, Żaneta Broniowska, Bogusława Budziszewska
    Conference:
    18th World Kongress of Basic and Clinical Pharmacology (rok: 2018, ), Wydawca: Japanese Pharmcological Society
    Data:
    konferencja 01.07-06.07. 2018
    Status:
    Published
  5. The effect of benzophenone-3 on the steroid receptors expression in the brain
    Authors:
    Beata Starek-Swiechowicz, Zaneta Broniowska, Bartosz PomiernWeronika Krzyzanowska, Beata Strach, Agnieszka Basta-Kaim, Boguslawa Budziszewska
    Conference:
    18th World Kongress of Basic and Clinical Pharmacology (rok: 2018, ), Wydawca: Japanese Pharmcological Society
    Data:
    konferencja 01.07-06.07. 2018
    Status:
    Published

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