Projects funded by the NCN
New 2(5H)-furanone derivatives with tailored hydrophobicity of substitutents - synthesis, molecular targets, mechanism of action and anticancer activity in vitro in breast cancer cell lines
2016/21/B/NZ7/01766
Keywords:
2(5H)-furanone molecural targets MDM-2 MDM-X cancer
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
- NZ7_16: Other related subjects
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Politechnika Śląska, Wydział Chemiczny
woj. śląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 7
Call: OPUS 11 - announced on 2016-03-15
Amount awarded: 1 073 510 PLN
Project start date (Y-m-d): 2017-02-09
Project end date (Y-m-d): 2020-10-08
Project duration:: 44 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Wymrażacz do pompy membarnowej (19 000 PLN)
- olejowa pompa próżniowa.
- Mieszadło magnetyczne z płytą grzewczą (2 szt.) (9 000 PLN)
- Wyparka rotacyjna z pompą ptóżniową (28 000 PLN)
- vortex.
- Mieszadło magnetyczne z płytą grzewczą.
Information in the final report
- Publication in academic press/journals (2)
- Effect of selected silyl groups on the anticancer activity of 2 3,4-dibromo-5-hydroxy-furan-2(5H)-one derivativesAuthors:Radosław Kitel, Anna Byczek-Wyrostek, Katarzyna Hopko, Anna Kasprzycka, Krzysztof WalczakAcademic press:Pharmaceuticals (rok: 2021, tom: 14, strony: 1079), Wydawca: MDPIStatus:SubmittedDOI:10.3390/ph14111079 - link to the publication
- Simple 2(5H)-furanone derivatives with selective cytotoxicity towards non-small cell lung cancer cell line A549 – Synthesis, structure-activity relationship and biological evaluationAuthors:A. Byczek-Wyrostek, R. Kitel, K. Rumak, M. Skonieczna, A. Kasprzycka, K. WalczakAcademic press:European Journal of Medicinal Chemistry (rok: 2018, tom: 150, strony: 687-697), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2018.03.021 - link to the publication