Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanisms of high sensitivity of pathogenic fungi belonging to the genus Cryptococcus to the action of new potential anticancer and antifungal drug - 3-bromopyruvate (3-BP)

2015/19/N/NZ7/00956

Keywords:

Cryptococcus spp. 3-bromopyruvate transport heterologous gene expression glutathione

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ2_1: Molecular genetics
  • NZ6_7: Mycology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Przywara 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 98 447 PLN

Project start date (Y-m-d): 2016-08-19

Project end date (Y-m-d): 2019-08-18

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora laminarna (Polon - nr kat. KL-21) (18 819 PLN)
  2. komputer - HP (4 000 PLN)
  3. Microjet - Enbio - autoklaw (5 228 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. 3‐Bromopyruvate as a potent anti-cancer therapy in honor and memory of the late Professor André Goffeau
    Authors:
    Young H. Ko, Katarzyna Niedźwiecka, Margarida Casal, Peter L. Pedersen, Stanisław Ułaszewski
    Academic press:
    Yeast (rok: 2018, tom: 2018, strony: 45302), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1002/yea.3367 - link to the publication
  2. The Cryptococcus neoformans monocarboxylate transporter Jen4 is responsible for increased 3-bromopyruvate sensitivity.
    Authors:
    Katarzyna Niedźwiecka, David Ribas, Margarida Casal, Stanisław Ułaszewski
    Academic press:
    FEMS Yeast Research (rok: 2019, tom: 19, strony: pii: foz029), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/femsyr/foz029 - link to the publication
  3. The HK2 Dependent Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
    Authors:
    Paweł Lis, Mariusz Dyląg, Katarzyna Niedźwiecka, Young H. Ko, Peter L. Pedersen, Andre Goffeau and Stanisław Ułaszewski
    Academic press:
    Molecules (rok: 2016, tom: 21, strony: pii: E1730), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules21121730 - link to the publication
  4. Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma
    Authors:
    Katarzyna Niedźwiecka, Mariusz Dyląg, Daria Augustyniak, Grażyna Majkowska-Skrobek, Magdalena Cal-Bąkowska, Young H. Ko, Peter L. Pedersen, Andre Goffeau, Stanisław Ułaszewski
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 65614 - 65626), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.11592 - link to the publication

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