Projects funded by the NCN

The effects of ligands of the alpha7 nicotinic acetylcholine receptors on complex cognitive processes and social behavio...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Agnieszka Potasiewicz

Instytut Farmakologii PAN

How does second language proficiency and immersion experience modulate interference between languages? Control mechanism...

Call: PRELUDIUM 8 , Panel: HS6

Principal investigator: Joanna Durlik-Marcinowska

Uniwersytet Jagielloński, Wydział Filozoficzny

Search for the mechanisms of the modulation of canonical Wnt signaling which effectively attenuate the survival of head ...

Call: SONATA 7 , Panel: NZ7

Principal investigator: dr Jarosław Paluszczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Analysis of the structural and functional mechanisms of action of the nicotinic receptors modulators.

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Katarzyna Targowska-Duda

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

The effects of positive allosteric modulators of alpha7 nicotinic acetylcholine receptors on complex cognitive processes...

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Nikiforuk

Instytut Farmakologii PAN

Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric ...

Call: SONATA 4 , Panel: NZ1

Principal investigator: dr Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Evaluation of the synthesis and metabolism modulation of estrogens - breast cancer risk factors by new synthetic resvera...

Call: OPUS 3 , Panel: NZ7

Principal investigator: prof. Wanda Baer-Dubowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

The role of corticotropin releasing factor (CRF) in low and high anxiety rats, and teh iteraction between of the CRF sys...

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr Anna Skórzewska

Instytut Psychiatrii i Neurologii

Probing the selectivity of zinc allosteric modulation in various serotonin receptor subtypes

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: Grzegorz Satała

Instytut Farmakologii PAN

Taming aggregation with AmyloGraph 2.0: a database and prediction models of amyloid self-assembly modulators

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Michał Burdukiewicz

Uniwersytet Medyczny w Białymstoku

Modulation of the N-glycosylation as a tool to improve the CAR-T immunotherapy efficacy

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Agnieszka Graczyk-Jarzynka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński, Collegium Medicum

Amorphous Senolytics: A Breakthrough Approach in Senescence Modulation and Age-Related Disease Treatment

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Szymon Sip

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Selective PPARγ modulation by amorfrutin B as a novel therapeutic approach to chemotherapy-induced damage to mammalian b...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Bernadeta Pietrzak-Wawrzyńska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Potential of TH cell profiling in personalized multiple sclerosis treatmentplanning.

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Donskow-Łysoniewska

Uczelnia Łazarskiego

Histone demethylase inhibitors as chemosensitivity modulators in the treatment of head and neck squamous cell carcinoma

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Dawid Dorna

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

New positive allosteric modulators of EAAT2 glutamate transporter as candidates for treatment of neurological and psychi...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Krzysztof Kamiński

Uniwersytet Jagielloński, Collegium Medicum

Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Karolina Przepiórska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

'Mitotherapy as a novel strategy for the modulation of immunometabolic phenotype of fibroblast-like synoviocytes (FLS) –...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Krzysztof Marycz

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Biologii i Hodowli Zwierząt

Targeting UDP-glucose and P2Y14 receptor interaction for therapeutic modulation of inflammatory lung diseases

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Tadeusz Karcz

Uniwersytet Jagielloński, Collegium Medicum

Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Katarzyna Kieć-Kononowicz

Uniwersytet Jagielloński, Collegium Medicum

New strategies in the pharmacotherapy of neuropathic pain based on modulation of the chemokine system and its influence ...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Joanna Mika

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Modulation of immune cells activity in the tumor microenvironment by oligonucleotide therapeutics delivered by silk nano...

Call: OPUS 19 , Panel: NZ6

Principal investigator: dr hab. Hanna Dams-Kozłowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Exploring new drug targets for efficacious therapy of neuropathic pain basing on the assessment and modulation of neuroi...

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Joanna Mika

Instytut Farmakologii PAN

Biotic and abiotic stress elicitors as modulators of isoquinoline alkaloid profile towards specific antimicrobial proper...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Sylwia Zielińska

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Modulation of exosome production to support anti-cancer treatment

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Markus Düchler

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

SARMs as a modulators of metabolic functions and oxidative stress in adipose and heart tissues in rat obesity model- in ...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Natalia Leciejewska

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

Pharmacological modulation of histamine H3 and H4 receptors - a new perspective in the treatment of neuropathic pain

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Katarzyna Popiołek-Barczyk

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Galactosylceramide as a regulator of apoptotic gene expression and modulator of drug resistance in breast cancer cells.

Call: OPUS 18 , Panel: NZ5

Principal investigator: prof. Maciej Ugorski

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Medycyny Weterynaryjnej

Specific interactions of new antitumor unsymmetrical bisacridines, UAs, with DNA and ABC proteins and their potential to...

Call: OPUS 17 , Panel: NZ7

Principal investigator: prof. Zofia Mazerska

Politechnika Gdańska

The role of nitric oxide-dependent pathways in the procognitive effects of muscarinic and metabotropic glutamate recepto...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Joanna Wierońska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Marcin Ratajewski

Instytut Biologii Medycznej Polskiej Akademii Nauk

The influence of muscarinic acetylcholine receptors (M1, M4 and M5) and serotonergic 5-HT1A receptor modulation on cogni...

Call: PRELUDIUM 16 , Panel: NZ7

Principal investigator: dr Paulina Cieślik

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Novel, rationally designed modulators of glycosomal import of enzymes in Trypanosoma parasites

Call: OPUS 16 , Panel: NZ7

Principal investigator: dr hab. Maciej Dawidowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Gut microbiota dependent modulation of therapeutic response and side effects to irinotecan and new camptothecin analogue...

Call: OPUS 16 , Panel: NZ7

Principal investigator: prof. Jerzy Ostrowski

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

Prolonged high intensity interval training (HIIT) modulates inflammation through the specific microRNAs level changes in...

Call: PRELUDIUM 16 , Panel: NZ7

Principal investigator: Paulina Małczyńska-Sims

Instytut Psychiatrii i Neurologii

Evaluation of therapeutic role of novel positive allosteric modulators of GABA-A receptor in ischemic brain stroke

Call: SONATA BIS 8 , Panel: NZ7

Principal investigator: dr Monika Marcinkowska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

New strategies in neuropathic pain pharmacotherapy based on the modulation of the functions of chemokine receptors CCR2 ...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: dr Klaudia Kwiatkowski

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Modulation of the structure and properties of curcumin using triterpene oleanolic modifiers

Call: PRELUDIUM 14 , Panel: NZ7

Principal investigator: Katarzyna Sowa-Kasprzak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Modulation of inflammatory processes using new agonists of the formyl peptide receptors ALX/FPR2 as a new therapeutic st...

Call: HARMONIA 9 , Panel: NZ7

Principal investigator: prof. Agnieszka Basta-Kaim

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Combined urinary bladder cancer treatment with isothiocyanate-derived mercapturic acids and microtubule assembly modulat...

Call: SONATA 13 , Panel: NZ7

Principal investigator: dr Mateusz Psurski

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

The role of tumor secretable factors in modulation of endothelial senescence cells activity

Call: SONATA 13 , Panel: NZ7

Principal investigator: dr Wojciech Ciszewski

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu, Katedra Nauk Biomedycznych

Modulation of electrophysiological properties of the spinal cord motoneurons in response to trans-spinal direct current ...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Piotr Krutki

Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu, Wydział Nauk o Zdrowiu

The evaluation of the efficacy of alpha7 nicotinic acetylcholine receptor ligands in rat models of autism

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Nikiforuk

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Determination of the mechanisms and potential targets for neuropathic pain therapy by investigating pharmacological inte...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Anna Piotrowska-Murzyn

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Evaluation of SLC22A5 activity modulation in sensitizing glioma cells to the suppression of fatty acid oxidation by CPT1...

Call: PRELUDIUM 12 , Panel: NZ3

Principal investigator: Barbara Juraszek

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

Old drugs - new perspectives: modulation of antibiotics activity by caffeine and pentoxifylline

Call: SONATA 11 , Panel: NZ7

Principal investigator: dr Anna Woziwodzka

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Modulation of the expression and activation of transcription factors Nrf2 and NF-kappaB by new synthetic triterpenoids a...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Wanda Baer-Dubowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

New amide derivatives of cinnamic acid as a carbonyl reductase inhibitors, which modulate the activity of doxorubicin - ...

Call: SONATA 11 , Panel: NZ7

Principal investigator: dr Paulina Koczurkiewicz-Adamczyk

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny