DNA methylation as a modulating factor of response to thiopurine drugs in patients with inflammatory bowel disease
2017/25/B/NZ5/02783
Keywords
Descriptors
- NZ5_7: Leczenie chorób człowieka
- NZ5_5: Diagnostyka chorób człowieka
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
prof. Jarosław Mirosław Walkowiak
Number of co-investigators in the project: 5
Call
OPUS 13 – announced on 2017-03-15
- Amount awarded
- 1 978 980 PLN
- Project start date
- 2018-02-07
- Project end date
- 2025-02-06
- Project duration
- 84 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (13)
-
Immune cell-specific smoking-related expression characteristics are revealed by re-analysis of transcriptomes from the CEDAR cohort.
- Authors:
- Nowak JK, Dybska E, Adams AT, Walkowiak J.
- Academic press:
- Central European Journal of Immunology (year: 2022, volume: 47, pages: 246-259), Publisher: Termedia
- Status:
- Published
- DOI:
- 10.5114/ceji.2022.120618 – link to the publication
-
Methylation of RUNX3 Promoter 2 in the Whole Blood of Children with Ulcerative Colitis
- Authors:
- Dybska E, Nowak JK, Banaszkiewicz A, Szaflarska-Popławska A, Kierkuś J, Kwiecień J, Grzybowska-Chlebowczyk U, Walkowiak J.
- Academic press:
- Genes (Basel). (year: 2022, volume: 13, pages: 1568), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/genes13091568 – link to the publication
-
Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells.
- Authors:
- Nowak JK, Dworacka M, Gubaj N, Dossimov A, Dossimov Z, Walkowiak J.
- Academic press:
- Allergy, asthma, and clinical immunology (year: 2021, volume: 17, pages: 82), Publisher: BioMed Central
- Status:
- Published
- DOI:
- 10.1186/s13223-021-00584-9 – link to the publication
-
Ileal Lactase Expression Associates with Lactase Persistence Genotypes.
- Authors:
- Nowak JK, Dybska E, Dworacka M, Tsikhan N, Kononets V, Bermagambetova S, Walkowiak J.
- Academic press:
- Nutrients (year: 2021, volume: 13, pages: 1340), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/nu13041340 – link to the publication
-
HLA-DQA1*05 Associates with Extensive Ulcerative Colitis at Diagnosis: An Observational Study in Children.
- Authors:
- Nowak JK, Glapa-Nowak A, Banaszkiewicz A, Iwańczak B, Kwiecień J, Szaflarska- Popławska A, Grzybowska-Chlebowczyk U, Osiecki M, Kierkuś J, Hołubiec M, Chanaj- Kaczmarek J, Radzikowski A, Walkowiak J.
- Academic press:
- Genes (Basel) (year: 2021, volume: 12, pages: 1934), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/genes12121934. – link to the publication
-
Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2
- Authors:
- Nowak JK, Adams AT, Kalla R, Lindstrøm JC, Vatn S, Bergemalm D, Keita ÅV, Gomollón F, Jahnsen J, Vatn MH, Ricanek P, Ostrowski J, Walkowiak J, Halfvarson J, Satsangi J.
- Academic press:
- Journal of Crohn's & colitis. (year: 2022, volume: 16, pages: 1255-1268), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1093/ecco-jcc/jjac033. – link to the publication
-
Differential correlation network analysis of rectal transcriptomes reveals cystic fibrosis-related disturbance
- Authors:
- Nowak JK, Szymańska CJ, Walkowiak J.
- Academic press:
- Pharmacogenomics (year: 2022, volume: 23, pages: 339-344), Publisher: Taylor & Francis
- Status:
- Published
- DOI:
- 10.2217/pgs-2021-0138 – link to the publication
-
Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease-A Multi-Centre Cross-Sectional Study
- Authors:
- Glapa-Nowak A, Szczepanik M, Kwiecień J, Szaflarska-Popławska A, Flak-Wancerz A, Iwańczak B, Osiecki M, Kierkuś J, Pytrus T, Lebensztejn D, Banasiewicz T, Banaszkiewicz A, Walkowiak J
- Academic press:
- Journal of Clinical Medicine (year: 2020, volume: 9, pages: 3957), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/jcm9123957 – link to the publication
-
Apolipoprotein E variants correlate with the clinical presentation of paediatric inflammatory bowel disease: A cross-sectional study
- Authors:
- Glapa-Nowak A, Szczepanik M, Iwańczak B, Kwiecień J, Szaflarska-Popławska AB, Grzybowska-Chlebowczyk U, Osiecki M, Dziekiewicz M, Stawarski A, Kierkuś J, Banasiewicz T, Banaszkiewicz A, Walkowiak J
- Academic press:
- World Journal of Gastroenterology (year: 2021, volume: 27, pages: 1483-1496), Publisher: Baishideng Publishing Group
- Status:
- Published
- DOI:
- 10.3748/wjg.v27.i14.1483 – link to the publication
-
Waiting in the wings: RUNX3 reveals hidden depths of immune regulation with potential implications for inflammatory bowel disease.
- Authors:
- Dybska E, Adams AT, Duclaux-Loras R, Walkowiak J, Nowak JK.
- Academic press:
- Scandinavian journal of immunology (year: 2021, volume: 93, pages: e13025), Publisher: Universitetsforlaget
- Status:
- Published
- DOI:
- 10.1111/sji.13025 – link to the publication
-
Genetic Variants of DMBT1 and SFTPD and Disease Severity in Paediatric Inflammatory Bowel Disease-A Polish Population - Based Study.
- Authors:
- Glapa-Nowak A, Szczepanik M, Banaszkiewicz A, Iwańczak B, Kwiecień J, Szaflarska-Popławska A, Grzybowska-Chlebowczyk U, Osiecki M, Kierkuś J, Banasiuk M, Banasiewicz T, Madsen J, Walkowiak J.
- Academic press:
- Children (Basel) (year: 2021, volume: 8, pages: 946), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/children8110946 – link to the publication
-
Unexpected Actors in Inflammatory Bowel Disease Revealed by Machine Learning from Whole-Blood Transcriptomic Data
- Authors:
- Nowak JK, Szymańska CJ, Glapa-Nowak A, Duclaux-Loras R, Dybska E, Ostrowski J, Walkowiak J, Adams AT
- Academic press:
- Genes (Basel) (year: 2022, volume: 13, pages: 1570), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/genes13091570 – link to the publication
-
Transcriptomic Context of RUNX3 Expression in Monocytes: A Cross-Sectional Analysis.
- Authors:
- Dybska E, Nowak JK, Walkowiak J.
- Academic press:
- Biomedicines (year: 2023, volume: 11, pages: 1698), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/biomedicines11061698 – link to the publication