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Modulations of DNA repair induced by anti cancer drugs by thiosugars

2011/01/B/NZ4/03391

Keywords

Descriptors

  • NZ4_16: Farmacja
  • NZ4_11: Biologia nowotworów
  • ST5_20: Chemia pojedynczych cząsteczek i makrocząsteczek

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Tomasz Popławski

Number of co-investigators in the project: 6

Call

OPUS 1 – announced on 2011-03-15

Amount awarded
260 000 PLN
Project start date
2011-12-16
Project end date
2014-12-15
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Wirówka z chłodzeniem. Cost: 20 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. A novel carbohydrate derived compound FCP5 causes DNA strand breaks and oxidative modifications of DNA bases in cancer cells.

    Authors:
    Czubatka A, Sarnik J, Lucent D, Blasiak J, Witczak ZJ, Poplawski T.
    Academic press:
    Chemico-Biological Interactions (year: 2015, volume: 227, pages: 77-88), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2014.12.023 – link to the publication

  2. A potential CARB-pharmacophore for antineoplastic activity: part 1.

    Authors:
    Witczak ZJ, Poplawski T, Czubatka A, Sarnik J, Tokarz P, VanWert AL, Bielski R
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (year: 2014, volume: 24, pages: 1752-1757), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2014.02.036 – link to the publication

  3. Thio-sugar motif of functional CARB-pharmacophore for antineoplastic activity. Part 2.

    Authors:
    Witczak ZJ, Sarnik J, Czubatka A, Forma E, Poplawski T.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (year: 2014, volume: 24, pages: 5606-5611), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2014.10.095 – link to the publication

Articles in post-conference publications (10)

  1. Cytotoxicity and genotoxicity of thio-sugars and their derivatives

    Authors:
    Czubatka A, Tokarz P, Witczak ZJ, Poplawski T
    Conference:
    27th International Carbohydrate Symposium (ICS27) (year: 2014, pages: 1), Publisher: ICS
    Date:
    conference 12-17.01
    Status:
    Published

  2. Cytotoxicity of thiosugars in cencer cell lines

    Authors:
    Sarnik J, Czubatka A, Witczak ZJ, Poplawski T
    Conference:
    XV National Academic Seminar of Biotechnology Students & V International Conference of Biotechnology Students (year: 2013, pages: 104), Publisher: University of Wroclaw
    Date:
    conference 22-24.10
    Status:
    Published

  3. Biological activity of thio-sugar derivatives on human colorectal adenocarcinoma cell line

    Authors:
    Czubatka A, Sarnik J, Witczak ZJ, Popławski T
    Conference:
    Gliwice Scientific Meetings (year: 2014, pages: 64), Publisher: Silesian University of Technology
    Date:
    conference 21-22.11
    Status:
    Published
    DOI:
    link to the publication

  4. Sugar analogs as a novel terapeutic agents against cancer

    Authors:
    Czubatka A, Tokarz P, Witczak ZJ, Poplawski T
    Conference:
    5th Central European Congress of Life Sciences: Eurobiotech 2013 (year: 2013, pages: 46), Publisher: Targi w Krakowie Ltd.
    Date:
    conference 8-11.11
    Status:
    Published

  5. Węglowodany w terapii kombinowanej z lekami przeciwnowotworowymi

    Authors:
    Czubatka A, Sarnik J, Witczak ZJ, Poplawski T
    Conference:
    III Studencka Konferencja Biologii Molekularnej (year: 2014, pages: 43), Publisher: Uniwersytet Łódzki
    Date:
    conference 20-22.03
    Status:
    Published

  6. The evaluation of Thio-disaccharides genotoxicity in human cervix adenocarcinoma (HeLa) cancer cell line

    Authors:
    Sarnik J, Czubatka A, Witczak ZJ, Popławski T
    Conference:
    Gliwice Scientific Meetings (year: 2014, pages: 134), Publisher: Silesian University of Technology
    Date:
    conference 21-22.11
    Status:
    Published
    DOI:
    link to the publication

  7. Induction of DNA lesions in cancer cells by thiosugar 1,5-anhydro-6-deoxy-6-methane-sulfamido-D-glucitol and its precursor 1,6-anhydro-5-C-hydroxymethyl-α-L-altro-pyranose

    Authors:
    Czubatka A, Sarnik J, Tokarz P, Witczak ZJ, Poplawski T
    Conference:
    Gliwice Scientific Meetings (year: 2013, pages: 189), Publisher: Silesian University of Technology
    Date:
    conference 15-16.11
    Status:
    Published
    DOI:
    link to the publication

  8. Thio-sugars can sensitize human cervix adenocarcinoma (HeLa) cancer cells to Bleomycin and ROS generator

    Authors:
    Sarnik J, Czubatka A, Popławski T, Witczak ZJ
    Conference:
    249th ACS National Meeting & Exposition (year: 2015, pages: MEDI 308), Publisher: ACS
    Date:
    conference 22-26.03
    Status:
    Published
    DOI:
    link to the publication

  9. Low glucose level enhances the cytotoxicity of CARB-pharmacophore to cancer cells

    Authors:
    Czubatka A, Sarnik J, Popławski T, Witczak ZJ
    Conference:
    249th ACS National Meeting & Exposition (year: 2015, pages: MEDI 309), Publisher: ACS
    Date:
    conference 22-26.03
    Status:
    Published
    DOI:
    link to the publication

  10. Modulacja naprawy DNA komórek nowotworowych przez tiocukry, sulfamidocukry oraz anhydrocukry

    Authors:
    Macieja A, Czubatka A, Popławski T
    Conference:
    Kopernikańskie Sympozjum Studentów Nauk Przyrodniczych (year: 2014, pages: 149), Publisher: Uniwersytet Mikołaja Kopernika
    Date:
    conference 28-30.03
    Status:
    Published

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