Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Modulations of DNA repair induced by anti cancer drugs by thiosugars

2011/01/B/NZ4/03391

Keywords:

tiosugars DNA repair anticancer drugs

Descriptors:

  • NZ4_16:
  • NZ4_11: Metabolism
  • ST5_20:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Popławski 

Number of co-investigators in the project: 6

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 260 000 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2014-12-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówka z chłodzeniem (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (10)
  1. A potential CARB-pharmacophore for antineoplastic activity: part 1.
    Authors:
    Witczak ZJ, Poplawski T, Czubatka A, Sarnik J, Tokarz P, VanWert AL, Bielski R
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2014, tom: 24, strony: 1752-1757), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2014.02.036 - link to the publication
  2. Thio-sugar motif of functional CARB-pharmacophore for antineoplastic activity. Part 2.
    Authors:
    Witczak ZJ, Sarnik J, Czubatka A, Forma E, Poplawski T.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2014, tom: 24, strony: 5606-5611), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.095 - link to the publication
  3. A novel carbohydrate derived compound FCP5 causes DNA strand breaks and oxidative modifications of DNA bases in cancer cells.
    Authors:
    Czubatka A, Sarnik J, Lucent D, Blasiak J, Witczak ZJ, Poplawski T.
    Academic press:
    Chemico-Biological Interactions (rok: 2015, tom: 227, strony: 77-88), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2014.12.023 - link to the publication
  1. Cytotoxicity of thiosugars in cencer cell lines
    Authors:
    Sarnik J, Czubatka A, Witczak ZJ, Poplawski T
    Conference:
    XV National Academic Seminar of Biotechnology Students & V International Conference of Biotechnology Students (rok: 2013, ), Wydawca: University of Wroclaw
    Data:
    konferencja 22-24.10
    Status:
    Published
  2. Low glucose level enhances the cytotoxicity of CARB-pharmacophore to cancer cells
    Authors:
    Czubatka A, Sarnik J, Popławski T, Witczak ZJ
    Conference:
    249th ACS National Meeting & Exposition (rok: 2015, ), Wydawca: ACS
    Data:
    konferencja 22-26.03
    Status:
    Published
    DOI:
    link to the publication
  3. Thio-sugars can sensitize human cervix adenocarcinoma (HeLa) cancer cells to Bleomycin and ROS generator
    Authors:
    Sarnik J, Czubatka A, Popławski T, Witczak ZJ
    Conference:
    249th ACS National Meeting & Exposition (rok: 2015, ), Wydawca: ACS
    Data:
    konferencja 22-26.03
    Status:
    Published
    DOI:
    link to the publication
  4. Induction of DNA lesions in cancer cells by thiosugar 1,5-anhydro-6-deoxy-6-methane-sulfamido-D-glucitol and its precursor 1,6-anhydro-5-C-hydroxymethyl-α-L-altro-pyranose
    Authors:
    Czubatka A, Sarnik J, Tokarz P, Witczak ZJ, Poplawski T
    Conference:
    Gliwice Scientific Meetings (rok: 2013, ), Wydawca: Silesian University of Technology
    Data:
    konferencja 15-16.11
    Status:
    Published
    DOI:
    link to the publication
  5. Sugar analogs as a novel terapeutic agents against cancer
    Authors:
    Czubatka A, Tokarz P, Witczak ZJ, Poplawski T
    Conference:
    5th Central European Congress of Life Sciences: Eurobiotech 2013 (rok: 2013, ), Wydawca: Targi w Krakowie Ltd.
    Data:
    konferencja 8-11.11
    Status:
    Published
  6. Biological activity of thio-sugar derivatives on human colorectal adenocarcinoma cell line
    Authors:
    Czubatka A, Sarnik J, Witczak ZJ, Popławski T
    Conference:
    Gliwice Scientific Meetings (rok: 2014, ), Wydawca: Silesian University of Technology
    Data:
    konferencja 21-22.11
    Status:
    Published
    DOI:
    link to the publication
  7. The evaluation of Thio-disaccharides genotoxicity in human cervix adenocarcinoma (HeLa) cancer cell line
    Authors:
    Sarnik J, Czubatka A, Witczak ZJ, Popławski T
    Conference:
    Gliwice Scientific Meetings (rok: 2014, ), Wydawca: Silesian University of Technology
    Data:
    konferencja 21-22.11
    Status:
    Published
    DOI:
    link to the publication
  8. Cytotoxicity and genotoxicity of thio-sugars and their derivatives
    Authors:
    Czubatka A, Tokarz P, Witczak ZJ, Poplawski T
    Conference:
    27th International Carbohydrate Symposium (ICS27) (rok: 2014, ), Wydawca: ICS
    Data:
    konferencja 12-17.01
    Status:
    Published
  9. Modulacja naprawy DNA komórek nowotworowych przez tiocukry, sulfamidocukry oraz anhydrocukry
    Authors:
    Macieja A, Czubatka A, Popławski T
    Conference:
    Kopernikańskie Sympozjum Studentów Nauk Przyrodniczych (rok: 2014, ), Wydawca: Uniwersytet Mikołaja Kopernika
    Data:
    konferencja 28-30.03
    Status:
    Published
  10. Węglowodany w terapii kombinowanej z lekami przeciwnowotworowymi
    Authors:
    Czubatka A, Sarnik J, Witczak ZJ, Poplawski T
    Conference:
    III Studencka Konferencja Biologii Molekularnej (rok: 2014, ), Wydawca: Uniwersytet Łódzki
    Data:
    konferencja 20-22.03
    Status:
    Published

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