Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Modulation of exosome production to support anti-cancer treatment

2019/35/B/NZ7/03256

Keywords:

Melanoma extracellular vesicles immunotherapy drug export drug sensitivity

Descriptors:

  • NZ7_005:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Liliana Monika Czernek 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 371 600 PLN

Project start date (Y-m-d): 2020-06-15

Project end date (Y-m-d): 2025-06-14

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  1. Revealing the role of RAB27 in HER receptor family expression and signaling in melanoma cells
    Authors:
    Katarzyna Horodecka, Liliana Czernek, Łukasz Pęczek & Magdalena Klink
    Academic press:
    Cell Communication and Signaling (rok: 2025, tom: 23, strony: 45670), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-025-02064-8 - link to the publication
  2. CRISPR/Cas9: Principle, Applications, and Delivery through Extracellular Vesicles
    Authors:
    Katarzyna Horodecka, Markus Düchler
    Academic press:
    Int J Mol Sci. (rok: 2021, tom: 22 (11), strony: 6072), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22116072 - link to the publication
  3. Small Extracellular Vesicles Loaded with Immunosuppressive miRNAs Leads to an Inhibition of Dendritic Cell Maturation
    Authors:
    Liliana Czernek, Łukasz Pęczek, Markus Düchler
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2022, tom: 70 (1), strony: 27), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00005-022-00664-7 - link to the publication
  4. CRISPR/Cas9: Principle, Applications, and Delivery through Extracellular Vesicles
    Authors:
    Katarzyna Horodecka, Markus Düchler
    Academic press:
    Int J Mol Sci. (rok: 2021, tom: 22 (11), strony: 6072), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22116072 - link to the publication
  5. Small Extracellular Vesicles Loaded with Immunosuppressive miRNAs Leads to an Inhibition of Dendritic Cell Maturation
    Authors:
    Liliana Czernek, Łukasz Pęczek, Markus Düchler
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2022, tom: 70 (1), strony: 27), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00005-022-00664-7 - link to the publication
  6. Impact of Rab27 on Melanoma Cell Invasion and sEV Secretion
    Authors:
    Katarzyna Horodecka 1, Liliana Czernek 1, Łukasz Pęczek 1, Mariusz Gadzinowski 1, Magdalena Klink
    Academic press:
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (rok: 2024, tom: 25(22), strony: 45675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms252212433 - link to the publication
  1. Functional implication of Rab27 in pro-invasive status of melanoma cells.
    Authors:
    Katarzyna Horodecka, Liliana Czernek, Łukasz Pęczek , Magdalena Klink
    Conference:
    American Society for Cell Biology. 2023 ASCB Annual Meeting Abstracts (rok: 2024, tom: 2023 ASCB Annual Meeting, strony: 1;35(1):ar12), Wydawca: Molecular Biology of the Cell
    Data:
    konferencja 45262
    Status:
    Published
    DOI:
    10.1091/mbc.E23-10-0402 - link to the publication
  2. The role of Rab27 in melanoma cell invasion and exosomal secretion
    Authors:
    Katarzyna Horodecka, Liliana Czernek, Łukasz Pęczek , Magdalena Klink
    Conference:
    FEBS Open Bio Volume 13, Issue S2 Supplement: Together in bioscience for a better future (rok: 2023, tom: FEBS Open Bio, strony: 46), Wydawca: Wiley
    Data:
    konferencja 45115
    Status:
    Published
    DOI:
    10.1002/2211-5463.13645 - link to the publication