Projects funded by the NCN

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77 projects found matching your search criteria :

  1. Assessment of the state and function of the brain cholinergic system in animal models of Alzheimer-type and frontotempor...

    Call: OPUS 8 , Panel: NZ4

    Principal investigator: dr hab. Grażyna Niewiadomska

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  2. Search for early molecular mechanisms and markers of preclinical stage of sporadic form of Alzheimer's disease (SAD) in ...

    Call: SONATA 8 , Panel: NZ4

    Principal investigator: dr Anna Mietelska-Porowska

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  3. The role of bioactive sphingolipids: ceramide, ceramide-1-phosphate and sphingosine-1-phosphate in regulation of mitocho...

    Call: OPUS 8 , Panel: NZ3

    Principal investigator: dr hab. Robert Strosznajder

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  4. Approach to structures of difficult protein targets using new mass spectrometry-based methods

    Call: MAESTRO 6 , Panel: NZ1

    Principal investigator: prof. Michał Dadlez

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  5. Proteomic analysis of changes in brain and liver mitochondria in apoE-knockout mice – influence of metformin – an AMP-ac...

    Call: PRELUDIUM 1 , Panel: NZ2

    Principal investigator: dr Maciej Suski

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

  6. The influence of nanoparticles on beta-amyloid removal by microglia cells

    Call: PRELUDIUM 6 , Panel: NZ7

    Principal investigator: Katarzyna Sikorska

    Instytut Chemii i Techniki Jądrowej

  7. Inhibitors of ER stress dependant PERK kinase as a novel approach for Alzheimer's therapy

    Call: HARMONIA 5 , Panel: NZ1

    Principal investigator: prof. Ireneusz Majsterek

    Uniwersytet Medyczny w Łodzi, Wydział Wojskowo-Lekarski

  8. Conjugates of prion protein with dendrimers as inhibitors of Abeta peptide amyloidogenesis and cytotoxicity of potential...

    Call: HARMONIA 5 , Panel: NZ4

    Principal investigator: dr hab. Krzysztof Nieznański

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  9. Searching for biological functions of APP family of proteins and APP-derived fragments in olfactory system.

    Call: OPUS 5 , Panel: NZ3

    Principal investigator: dr hab. Rafał Butowt

    Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  10. The influence of dimethyl fumarate on the spatial memory, neurogenesis, neurodegeneration and cerebral imflammation in t...

    Call: SONATA 5 , Panel: NZ4

    Principal investigator: dr Irena Majkutewicz

    Uniwersytet Gdański, Wydział Biologii

  11. Structural investigation of the active center of gamma-secretase and its interactions with selected substrates.

    Call: PRELUDIUM 5 , Panel: NZ2

    Principal investigator: Krzysztof Młynarczyk

    Uniwersytet Warszawski, Wydział Chemii

  12. FUNCTIONAL STUDIES OF RARE GENETIC VARIANTS OF GENES CAUSSALLY CONNECTED WITH ALZHEIMER'S DISEASE IN THE POLISH POPULATI...

    Call: SONATA 5 , Panel: NZ3

    Principal investigator: dr Michalina Wężyk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  13. The role of poly(ADP-ribose) polymerase and sirtuins in molecular mechanism of cell death. Identification of novel targe...

    Call: OPUS 5 , Panel: NZ3

    Principal investigator: prof. Joanna Strosznajder

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  14. Looking for the same pathological factors in ischemic brain and Alzheimer's disease;Genes

    Call: OPUS 5 , Panel: NZ7

    Principal investigator: prof. Ryszard Pluta

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  15. Synthetic cysteine peptides as molecular layers for studies of interactions between copper ions and beta-amyloid

    Call: SONATA 4 , Panel: ST4

    Principal investigator: dr Urszula Wawrzyniak

    Politechnika Warszawska, Wydział Chemiczny

  16. Determination of physicochemical and biochemical propertiess of natural pyridine and piperidine alkaloids and their simp...

    Call: PRELUDIUM 4 , Panel: NZ7

    Principal investigator: dr Damian Szczesny

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  17. Search of novel multifunctional ligands targeting neurodegereneration processes.

    Call: OPUS 4 , Panel: NZ7

    Principal investigator: prof. Barbara Malawska

    Uniwersytet Jagielloński-Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  18. Functional, epigenetic and genetic aspects of base excision repair pathway in Alzheimer's disease

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr hab. Tomasz Śliwiński

    UNIWERSYTET ŁÓDZKI, Wydział Biologii i Ochrony Środowiska

  19. The role of acquired channelopathies in facilitationg post-traumatic epileptogenesis in APP/PS1 transgenic mice - an ani...

    Call: PRELUDIUM 3 , Panel: NZ4

    Principal investigator: Diana Miszczuk

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  20. An attempt to elucidate the role of clusterin and lipid rafts in Alzheimer's disease etiology.

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: prof. Arkadiusz Orzechowski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  21. Effect of phosphorylation of Aβ peptides on the redox activity oftheir copper complexes and aggregation in the context o...

    Call: SONATA 19 , Panel: ST4

    Principal investigator: dr Nina Wezynfeld

    Politechnika Warszawska, Wydział Chemiczny

  22. First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: prof. Jadwiga Handzlik

    Uniwersytet Jagielloński, Collegium Medicum

  23. ROS-Scavenging Magnetic Nanozymes with Remote Activation for Alzheimer Disease

    Call: M-ERA.NET 3 Call 2023 , Panel: NZ5

    Principal investigator: dr hab. Anna Haduch

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  24. Deciphering the Chemoproteomics and Chemotranscriptomics of Anti-Alzheimer Drugs for Novel Druggable Target Identificati...

    Call: JPND Call 2023 , Panel: NZ5

    Principal investigator: prof. Krzysztof Sobczak

    Uniwersytet im. Adama Mickiewicza w Poznaniu

  25. (Micro)RNA and informatics approaches for diagnosis, prognosis and treatment of Alzheimer's disease and Dementia

    Call: JPND Call 2023 , Panel: NZ3

    Principal investigator: dr hab. Agnieszka Fiszer

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  26. Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr Anna Zawadzka

    Uniwersytet Warszawski, Wydział Chemii

  27. Local molecular changes in amyloid-β altered by green tea's active compounds

    Call: PRELUDIUM 22 , Panel: ST4

    Principal investigator: Michał Czaja

    Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  28. Blood plasma microRNA profile as a basis for detecting Alzheimer's disease and dementia risk in pre-symptomatic individu...

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: prof. Urszula Wojda

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  29. Study of the regenerative potential of Stem Cells from Human Exfoliated Deciduous teeth (SHED) in Alzheimer's disease

    Call: POLONEZ BIS 3 , Panel: NZ3

    Principal investigator: dr Leila Elyasi

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  30. The role of CDK5 in inflammatory reaction in experimental model of Alzheimer's disease

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: dr hab. Grzegorz Czapski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  31. Defining (sex and age) cell-specific epigenetic mechanisms underlying EnvironmentalEnrichment/Exercise as non-pharmacolo...

    Call: JPND Call 2022 , Panel: NZ2

    Principal investigator: dr hab. Bartosz Wilczyński

    Uniwersytet Warszawski

  32. Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Karolina Przepiórska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  33. Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Kinga Czarnota-Łydka

    Uniwersytet Jagielloński, Collegium Medicum

  34. Effects of activation of cholinergic, noradrenergic, and serotonergic systems on respiratory impairment in Alzheimer's d...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Kaczyńska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  35. Development of the knowledge on the role of GPR18 ligands as a microglia-targeted strategy in the regulation of neuroinf...

    Call: SONATA 17 , Panel: NZ3

    Principal investigator: dr Ewelina Honkisz-Orzechowska

    Uniwersytet Jagielloński, Collegium Medicum

  36. Bleomycin hydrolase, homocysteine metabolism, epigenetic regulation of mTOR signalling, autophagy, and Alzheimer's disea...

    Call: OPUS 22 , Panel: NZ4

    Principal investigator: prof. Hieronim Jakubowski

    Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Bioinżynierii

  37. New approach to the treatment of Alzheimer's disease targetingresolution of inflammation and modulation of biomechanical...

    Call: OPUS 22 , Panel: NZ4

    Principal investigator: prof. Agnieszka Basta-Kaim

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  38. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

    Call: OPUS 22 (LAP) , Panel: NZ7

    Principal investigator: prof. Kinga Sałat

    Uniwersytet Jagielloński, Collegium Medicum

  39. Presymptomatic synaptic disorders in Alzheimer's disease

    Call: JPco-fuND2 Call 2021 , Panel: NZ5

    Principal investigator: dr Michalina Wężyk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  40. Role of Amyloid Precursor Protein in the regulation of store-operated calcium entry

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: dr Tomasz Węgierski

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  41. Potential neuroprotective properties of modulators of sphingosine-1-phosphate (S1P) receptors (fingolimod and siponimod)...

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: Iga Wieczorek

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  42. Selective inhibitors of γ-aminobutyric acid (GABA) transporter subtype 3 (GAT3) as a new pharmacological tools and a cha...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: dr Dawid Panek

    Uniwersytet Jagielloński, Collegium Medicum

  43. Spectroelectrochemistry of Alzheimer's disease - a study of a new potential therapeutic molecule

    Call: SONATINA 5 , Panel: ST4

    Principal investigator: dr Magdalena Wiloch

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  44. Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic...

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: prof. Małgorzata Kajta

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  45. Direct monitoring of the local dynamic rearrangement of the Alzheimer's peptides secondary structure upon the aggregatio...

    Call: OPUS 19 , Panel: ST4

    Principal investigator: dr hab. Ewelina Lipiec

    Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  46. Deficits of spontaneous retrieval in older individuals with periodontitis: search for early cognitive dementia markers

    Call: PRELUDIUM 19 , Panel: HS6

    Principal investigator: Michał Wereszczyński

    Uniwersytet Jagielloński, Wydział Filozoficzny

  47. New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Anna Pasieka

    Uniwersytet Jagielloński, Collegium Medicum

  48. Towards innovative strategy for treatment of Alzheimer's Disease via dual inhibition of receptor 5-HT6 and kinase CDK5.

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Sylwia Sudoł

    Uniwersytet Jagielloński, Collegium Medicum

  49. Cortical reinstatement in health and Alzheimer's' disease: a direct approach to testing the hippocampal memory indexing ...

    Call: CEUS-UNISONO , Panel: NZ4

    Principal investigator: dr Rafał Czajkowski

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  50. Structural studies of the influence of selected surfactants on the amyloidogenic properties of various forms of beta pep...

    Call: ETIUDA 8 , Panel: ST4

    Principal investigator: Michalina Wilkowska

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

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