Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of Pon1 in Alzheimer Disease.

2018/29/B/NZ4/00771

Keywords:

Hyperhomocysteinemia Homocysteine Tiolakton protein agregation paraoxonase 1 Alzheimer Disease

Descriptors:

  • NZ4_11: Metabolism
  • NZ5_7: Human disease treatment
  • NZ2_3: Proteomics

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Bioinżynierii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hieronim Jakubowski 

Number of co-investigators in the project: 7

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 2 456 000 PLN

Project start date (Y-m-d): 2019-02-06

Project end date (Y-m-d): 2023-02-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Basen Morrisa (17 000 PLN)
  2. System do nagrywania i analizy testów behawioralnych (47 000 PLN)
  3. Komputer przenośny z Pakietem Office (6 470 PLN)
  4. mikroskop wraz z modułem sterującym, kamerą i oprogramowaniem (38 000 PLN)
  5. Aparat do pomiarow dynamicznego rozpraszania światła (DLS) (280 000 PLN)
  6. Mikroton do cięcia tkanek zamrożonych (72 000 PLN)
  7. Moduł do oprogramowania Ethovision (11 845 PLN)

Information in the final report

  • Publication in academic press/journals (28)
  • Articles in post-conference publications (4)
  1. Anti-N-homocysteinylated protein auto-antibodies are associated with impaired cognition.
    Authors:
    Włoczkowka O, Perła-Kaján J, Smith AD, de Jager C, Refsum H, Jakubowski H.
    Academic press:
    Alzheimer's Dement (rok: 2021, tom: 7(1), strony: e12159.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1002/trc2.12159 - link to the publication
  2. Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs-/- mice and thrombosis-prone CBS-/- humans.
    Authors:
    Sikora M, Lewandowska I, Marczak Ł, Bretes E, Jakubowski H
    Academic press:
    Sci Rep (rok: 2020, tom: 10(1), strony: 10726), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-020-67672-5 - link to the publication
  3. Depletion of paraoxonase 1 (Pon1) dysregulates mTOR, autophagy, and accelerates amyloid beta accumulation in mice.
    Authors:
    Witucki Ł, Jakubowski H.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 746), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12050746 - link to the publication
  4. Filaggrin expression and processing deficiencies impair corneocyte surface texture and stiffness in mice.
    Authors:
    Thyssen JP, Jakasa I, Riethmüller C, Schön MP, Braun A, Haftek M, Fallon PG, Wróblewski J, Jakubowski H, Eckhart L, Declercq W, Koppes S, Engebretsen KA, Bonefeld C, Irvine AD, Keita-Alassane S, Simon M, Kawasaki H, Kubo A, Amagai M, Matsui T, Kezic S
    Academic press:
    J Invest Dermatol (rok: 2020, tom: 140(3), strony: 615-623.e5), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jid.2019.07.716 - link to the publication
  5. Homocysteine Metabolites Inhibit Autophagy and Elevate Amyloid Beta by Impairing Phf8/H4K20me1-dependent Epigenetic Regulation of mTOR in Cystathionine Beta-Synthase-Deficient Mice
    Authors:
    Lukasz Witucki, Hieronim Jakubowski
    Academic press:
    bioRxiv (rok: 2023, tom: 2023.03.22., strony: 533769), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2023.03.22.533769 - link to the publication
  6. Paraoxonase 1, B Vitamins Supplementation, and Mild Cognitive Impairment.
    Authors:
    Perła-Kaján J, Włoczkowka O, Zioła-Frankowska A, Frankowski M, Smith AD, de Jager C, Refsum H, Jakubowski H.
    Academic press:
    J Alzheimer's Dis 2021;81:1211-1229 (rok: 2021, tom: 81, strony: 1211-1229), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-210137 - link to the publication
  7. Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic.
    Authors:
    Jakubowski H.
    Academic press:
    Expert Rev Proteomics (rok: 2020, tom: 17, strony: 751-765), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/14789450.2020.1865160 - link to the publication
  8. B Vitamins Prevent Iron-associated Brain Atrophy and Domain-specific Effects of Iron, Copper, Aluminum and Silicon on Cognition in Mild Cognitive Impairment
    Authors:
    Jakubowski H, Zioła-Frankowska A, Frankowski M, Perła-Kaján J, Refsum H, de Jager CA, Smith AD.
    Academic press:
    J Alzheimers Dis (rok: 2021, tom: 84(3):, strony: 1039-1055), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-215085 - link to the publication
  9. Cystathionine β-synthase gene inactivation dysregulates major urinary protein biogenesis and impairs sexual signaling in mice
    Authors:
    Ewa Bretes, Jacek Wróblewski, Monika Wyszczelska-Rokiel, Hieronim Jakubowski
    Academic press:
    bioRxiv (rok: 2022, tom: 2022.07.10., strony: 499408), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.499408 - link to the publication
  10. Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine β-synthase-deficient mice.
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    J Inherit Metab Dis (rok: 2023, tom: ?, strony: 45308), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1002/jimd.12661 - link to the publication
  11. Homocysteine thiolactone contributes to a prognostic value of fibrin clot structure/function in coronary artery disease.
    Authors:
    Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H.
    Academic press:
    PLOS ONE (rok: 2022, tom: 17, strony: e0275956), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0275956 - link to the publication
  12. Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease
    Authors:
    Łukasz Witucki, Monika Kurpik, Hieronim Jakubowski, Michał Szulc, Przemysław Łukasz Mikołajczak, Jadwiga Jodynis-Liebert, Małgorzata Kujawska
    Academic press:
    Nutrients (rok: 2022, tom: 14, strony: 2014), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu14102014 - link to the publication
  13. Telomere length and mtDNA copy number in human cystathionine β-synthase deficiency
    Authors:
    Utyro O, Perła-Kaján J, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Free Radic Biol Med (rok: 2020, tom: 160, strony: 219-226), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2020.07.036 - link to the publication
  14. Copper, heart disease and homocysteine thiolactone
    Authors:
    Jakubowski H
    Academic press:
    J Intern Med (rok: 2020, tom: x, strony: 45293), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1111/joim.13074 - link to the publication
  15. Cystathionine β-synthase gene inactivation dysregulates major urinary protein biogenesis and impairs sexual signaling in mice.
    Authors:
    Bretes E, Wróblewski J, Wyszczelska-Rokiel M, Jakubowski H.
    Academic press:
    FASEB Journal (rok: 2022, tom: 36, strony: e22547), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202200969R - link to the publication
  16. Depletion of bleomycin hydrolase (Blmh) downregulates histone demethylase Phf8, impairs mTOR signaling/autophagy, accelerates amyloid beta accumulation, and induces neurological deficits in mice
    Authors:
    Lukasz Witucki, Kamila Borowczyk, Joanna Suszynska-Zajczyk, Ewelina Warzych, Piotr Pawlak, Hieronim Jakubowski
    Academic press:
    bioRxiv (rok: 2023, tom: 2023.03.20., strony: 533511), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2023.03.20.533511 - link to the publication
  17. Proteomic Exploration of Paraoxonase 1 Function in Health and Disease
    Authors:
    Hieronim Jakubowski
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24, strony: 7764), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24097764 - link to the publication
  18. Quantification of homocysteine thiolactone in human saliva and urine by gas chromatography-mass spectrometry
    Authors:
    Piechocka J, Wrońska M, Chwatko G, Jakubowski H, Głowacki R
    Academic press:
    J Chromatogr B Analyt Technol Biomed Life Sci (rok: 2020, tom: 1149, strony: 122155), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2020.122155 - link to the publication
  19. Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice
    Authors:
    Sikora M, Marczak Ł, Perła-Kajan J, Jakubowski H
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 45299), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-38784-4 - link to the publication
  20. The Cbs Locus Affects the Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice
    Authors:
    Utyro O, Perła-Kaján J, Jakubowski H
    Academic press:
    Int J Mol Sci (rok: 2020, tom: 21(7), strony: 45310), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072520 - link to the publication
  21. The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study
    Authors:
    Majewska K, Kręgielska-Narożna M, Jakubowski H, Szulińska M, Bogdański P
    Academic press:
    J Clin Med (rok: 2020, tom: 9(4), strony: 45302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9040998 - link to the publication
  22. Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet. . 2021;169:169-180.
    Authors:
    Sikora M, Jakubowski H.
    Academic press:
    Free Radic Biol Med (rok: 2021, tom: 169, strony: 169-180), Wydawca: Elsevier
    Status:
    Published
    DOI:
    0.1016/j.freeradbiomed.2021.03.042 - link to the publication
  23. Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia
    Authors:
    Perła-Kaján J, Jakubowski H
    Academic press:
    Int J Mol Sci (rok: 2019, tom: 13, strony: 14611), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20133140 - link to the publication
  24. Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans
    Authors:
    Sikora M, Bretes E, Perła-Kaján J, Lewandowska I, Marczak Ł, Jakubowski H
    Academic press:
    Antioxidants (Basel) (rok: 2020, tom: 9, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9121198 - link to the publication
  25. Proteome-wide analysis of protein lysine N-homocysteinylation in Saccharomyces cerevisiae.
    Authors:
    Perła-Kaján J, Malinowska A, Zimny J, Cysewski D, Suszyńska-Zajczyk J, Jakubowski H
    Academic press:
    J Proteome Res (rok: 2021, tom: 20(5), strony: 2458-2476), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jproteome.0c00937 - link to the publication
  26. Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory- and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease.
    Authors:
    Łukasz Witucki, Kamila Borowczyk, Joanna Suszyńska-Zajczyk, Ewelina Warzych, Piotr Pawlak, Hieronim Jakubowski
    Academic press:
    Journal of Alzheimer's Disease (rok: 2023, tom: 94(4), strony: 1735-1755), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-230578 - link to the publication
  27. Homocysteine thiolactone contributes to a prognostic value of fibrin clot structure/function in coronary artery disease patients
    Authors:
    Marta Sikora, Paweł Skrzydlewski, Joanna Perła-Kaján, Hieronim Jakubowski
    Academic press:
    medRxiv (rok: 2022, tom: 2022.07.12., strony: 22277430), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2022.07.12.22277430 - link to the publication
  28. Serum Proteome Alterations in Human Cystathionine β-Synthase Deficiency and Ischemic Stroke Subtypes.
    Authors:
    Sikora M, Lewandowska I, Kupc M, Kubalska J, Graban A, Marczak Ł, Kaźmierski R, Jakubowski H
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: 12, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20123096 - link to the publication
  1. Autoantibodies against N-homocysteinylated proteins impair cognition: the VITACOG trial
    Authors:
    Olga Włoczkowska, Joanna Perła-Kajan, A. David Smith, Hieronim Jakubowski
    Conference:
    Homocysteine Mini-Conference (rok: 2020, ), Wydawca: Wydawnictwo Uniwersytetu pPrzyrodniczego w Poznaniu
    Data:
    konferencja 25 września 2020
    Status:
    Published
  2. Genetic attenuation of paraoxonase 1 activity induces pro-atherogenic changes in plasma proteomes of mice and humans,
    Authors:
    Marta Sikora, Ewa Bretes, Joanna Perła-Kaján, Łukasz Marczak, Hieronim Jakubowski.
    Conference:
    Homocysteine-Mini Conference (rok: 2020, ), Wydawca: Wydawnictwo Uniwersytetu pPrzyrodniczego w Poznaniu
    Data:
    konferencja 25 września 2020
    Status:
    Published
  3. Opposite associations of cysteine and cysteinylglycine with stroke
    Authors:
    Ewa Bretes, Olga Utyro, Joanna Perła-Kaján, Kamila Borowczyk, Rafał Głowacki, Radosław Kaźmierski, Hieronim Jakubowski.
    Conference:
    Homocysteine Mini-Conference (rok: 2020, ), Wydawca: Wydawnictwo Uniwersytetu pPrzyrodniczego w Poznaniu
    Data:
    konferencja 25 września 2020
    Status:
    Published
  4. Silencing Cbs or Blmh gene promotes accumulation of amyloid beta via the Phf8/H4K20me1/mTOR/autophagy pathway in mouse neuroblastoma N2A-APPswe cells
    Authors:
    Łukasz Witucki, Joanna Suszyńska-Zajczyk, Hieronim Jakubowski
    Conference:
    Homocysteine Mini-Conference (rok: 2020, ), Wydawca: Wydawnictwo Uniwersytetu pPrzyrodniczego w Poznaniu
    Data:
    konferencja 25 września 2020
    Status:
    Published

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