Projects funded by the NCN
Selective inhibitors of γ-aminobutyric acid (GABA) transporter subtype 3 (GAT3) as a new pharmacological tools and a chance for a novel therapy of GABA-related disorders.
2021/41/B/NZ7/02825
Keywords:
medicinal chemistry drug discovery γ-butyric acid γ-aminobutyric acid transporters inhibitors of γ-aminobutyric acid transporters, selective inhibitors of the GAT3-type transporter epilepsy neuropathic pain Alzheimer's disease
Descriptors:
- NZ7_014:
- NZ3_007:
- ST4_008:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Collegium Medicum
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 11
Call: OPUS 21 - announced on 2021-03-15
Amount awarded: 1 684 200 PLN
Project start date (Y-m-d): 2022-02-07
Project end date (Y-m-d): 2026-02-06
Project duration:: 48 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's diseaseAuthors:Paula Zaręba, Kamil Łątka, Gabriela Mazur, Beata Gryzło, Anna Pasieka, Justyna Godyń, Dawid Panek, Anna Skrzypczak-Wiercioch, Georg C Höfner, Gniewomir Latacz, Maciej Maj, Alba Espargaró, Raimon Sabaté, Krzysztof Jóźwiak, Klaus T Wanner, Kinga Sałat, Barbara Malawska, Katarzyna Kulig, Marek BajdaAcademic press:European Journal of Medicinal Chemistry (rok: 2023, tom: 261, strony: 115832), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2023.115832 - link to the publication
- Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studiesAuthors:Dawid Panek, Anna Pasieka, Gniewomir Latacz, Paula Zaręba, Michał Szczęch, Justyna Godyń, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Maria Walczak, Magdalena Smolik, Kinga Sałat, Georg Höfner, Klaus Wanner, Anna Więckowska, Barbara MalawskaAcademic press:The European Journal of Medicinal Chemistry (rok: 2023, tom: 249, strony: 115135), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2023.115135 - link to the publication
- Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's DiseaseAuthors:Dawid Panek, Anna Pasieka, Jakub Jończyk, Milena Gawlińska, Paula Zaręba, Agata Siwek, Małgorzata Wolak, Barbara Mordyl, Monika Głuch-Lutwin, Gniewomir Latacz, Xavier Brazzolotto, Fabien Chantegreil, Florian Nachon, Jana Zdarova Karasova, Jaroslav Pejchal, Martin Mzik, Vit Sestak, Lukas Prchal, Jitka Odvarkova, Ondrej Soukup, Jan Korabecny, Ales Sorf, Marie Hamsikova, Lucie Zemanova, Lubica Muckova, Nela Vánova, Pola Dryja, Kinga Sałat, Georg Höfner, Klaus Wanner, Anna Więckowska, Barbara MalawskaAcademic press:Angewandte Chemie International Edition (rok: 2024, tom: 64, strony: e202420510), Wydawca: WilleyStatus:PublishedDOI:10.1002/anie.202420510 - link to the publication