Projects funded by the NCN

The Dioscuri Centre for RNA-Protein Interactions in Human Health and Disease

Call: DIOSCURI 2 , Panel: NZ1

Principal investigator: dr Gracjan Michlewski

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej - Warszawa

On the trail of Vulnerability and Resilience: miRNA regulated Synaptic Protein Palmitoylation as the Basis of Stress Res...

Call: OPUS 29 , Panel: NZ5

Principal investigator: prof. Jakub Mateusz Włodarczyk

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Proteomic characterization, transcriptional and epigenetic regulation of drugtransporters in colorectal cancer

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Nina Ewa Komaniecka

Pomorski Uniwersytet Medyczny w Szczecinie

Design of RNA–protein interactions and complexes

Call: OPUS 29 , Panel: NZ1

Principal investigator: prof. Janusz Marek Bujnicki

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Phosphorylation-Dependent Regulation of IRS2 by DYRK1A: Implications for Diabetes Therapy

Call: PRELUDIUM 24 , Panel: NZ1

Principal investigator: Alicja Bis

Uniwersytet Jagielloński

Bioavaiability of doxycycline and its effect on the development of the mealworm (Tenebrio molitor)

Call: OPUS 29 , Panel: NZ4

Principal investigator: prof. Jerzy Jan Jaroszewski

Uniwersytet Warmińsko-Mazurski w Olsztynie

Immunogenicity assessment of dimeric tick-borne encephalitis virus E protein in mRNA and virus-like particles-based anti...

Call: PRELUDIUM 24 , Panel: NZ6

Principal investigator: Klaudia Katarzyna Barańska

Uniwersytet Gdański

Campylobacter jejuni protein expression, stress response and virulence modulated by methylation of 16S rRNA nucleotide C...

Call: PRELUDIUM 24 , Panel: NZ6

Principal investigator: Małgorzata Sylwia Murawska

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

Effect of pesticides on gene expression, secretory function, and inflammatory response of bovine mammary epithelial cell...

Call: PRELUDIUM 24 , Panel: NZ9

Principal investigator: Justyna Para

Uniwersytet Przyrodniczy we Wrocławiu

Unraveling RNA Degradation Mechanisms in the Mitochondrial Unfolded Protein Response

Call: PRELUDIUM 24 , Panel: NZ3

Principal investigator: Sylwia Kozioł

Uniwersytet Wrocławski

The influence of non-trivial topology on protein degradation by ClpXP in the context of degron design.

Call: OPUS 29 , Panel: NZ1

Principal investigator: dr Fernando Bruno da Silva

Uniwersytet Warszawski

LLT1 as a regulator of the immune response and a dual-target immunotherapy approach in colorectal cancer directed at NK ...

Call: OPUS 29 , Panel: NZ6

Principal investigator: dr Marzena Dorota Lenart

Uniwersytet Jagielloński

The role of the ABCA1 protein in cholesterol metabolism and the organization of key cell membrane structures in the proc...

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Aleksandra Mordzińska-Rak

Uniwersytet Medyczny w Lublinie

Identification of proteolytic cleavage sites in peptide substrates using coarse-grained docking and machine learning met...

Call: OPUS 29 , Panel: NZ1

Principal investigator: dr hab. Michał Koliński

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Electrospun plant protein-based dressings functionalized with hirudin for chronic wound healing

Call: PRELUDIUM 24 , Panel: ST11

Principal investigator: Katarzyna Marszalik

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie

Regulation of protein import into the mitochondria and its impact on the human mitochondrial proteome

Call: OPUS 29 , Panel: NZ1

Principal investigator: prof. Agnieszka Małgorzata Chacińska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Molecular Pathogenesis and Precision Antisense Oligonucleotide Therapy for BAG3-Related Myofibrillar Myopathy Type 6 Usi...

Call: OPUS 29 , Panel: NZ2

Principal investigator: dr Estera Elmira Rintz

Uniwersytet Gdański

Disrupting the Toxic NMDAR/TRPM4 Protein Dialogue as a Novel Neuroprotective Strategy: Development of Small-Molecule Inh...

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Katarzyna Aleksandra Szafrańska

Uniwersytet Jagielloński

Development and study of peptide inhibitors of membrane fusion in flaviviruses, based on the STEM region of the tick-bor...

Call: PRELUDIUM 24 , Panel: NZ6

Principal investigator: Krzysztof Polaczek

Uniwersytet Gdański

Gene expression, protein concentration and enzymatic activity of redox enzymes in relation to trace element status in li...

Call: PRELUDIUM 24 , Panel: NZ1

Principal investigator: Jakub Piotr Adamus

Warszawski Uniwersytet Medyczny

Lipid-Proteasome Interplay in Aging and Proteostasis

Call: SONATINA 9 , Panel: NZ1

Principal investigator: Pankaj Thapa

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Targeted Degradation of the MLL Complex in Leukemia: A PROTAC-Based Therapeutic Strategy

Call: SONATINA 9 , Panel: ST5

Principal investigator: dr Natalia Anna Skrzypczak

Fundacja Uniwersytetu im. Adama Mickiewicza

Alterations in host protein trafficking during Human papillomavirus infection and oncogenesis

Call: WEAVE-UNISONO , Panel: NZ6

Principal investigator: dr hab. Justyna Karolina Broniarczyk

Uniwersytet im. Adama Mickiewicza w Poznaniu

Disrupted SorCS2-dependent neuronal protein sorting in neonatal epilepticencephalopathy: functional studies in human iPS...

Call: SONATINA 9 , Panel: NZ5

Principal investigator: dr Aleksandra Tempes

Uniwersytet Warszawski

The role of DNA methylation in therapy that increases CFTR channel activity in cystic fibrosis

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Beata Maria Narożna

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Exploration of Natural Deep Eutectic Solvents (DES) for Innovative Biopolymer Extraction and Sustainable Biomass Valoris...

Call: OPUS 28 (LAP) , Panel: ST8

Principal investigator: dr hab. Maciej Wojciech Guzik

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Design of coiled-coil and alpha/beta non-trivial protein folds that self-assemble in silico and in vitro.

Call: OPUS 28 , Panel: NZ1

Principal investigator: dr hab. Joanna Ida Sułkowska

Uniwersytet Warszawski

An innovative approach to the elimination of cancer cells in disseminated ovarian cancer in various preclinical models b...

Call: OPUS 28 , Panel: NZ5

Principal investigator: dr hab. Joanna Ewa Jazowiecka-Rakus

Kardio-Med Silesia Sp. z o.o.

Clinical Variants of Hsp70 Chaperone HSPA1L in Protein Folding and Regulation of Glucocorticoid Receptor

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Agnieszka Antonina Kłosowska

Uniwersytet Gdański

Relation between intracranial aneurysm hemodynamic and proteomic profile

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Kornelia Maria Kliś

Uniwersytet Jagielloński

Modified nucleotide residues as potential tool to increase aptamer - target protein interaction

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Weronika Paulina Kotkowiak

Instytut Chemii Bioorganicznej PAN

Mechanistic and structural studies of adenoviral DNA replication

Call: OPUS 28 , Panel: NZ1

Principal investigator: prof. Marcin Piotr Nowotny

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Control of phospholipid composition of the inner mitochondrial membrane and its impact on protein translocase activity

Call: SONATA 20 , Panel: NZ1

Principal investigator: dr Klaudia Katarzyna Maruszczak

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Factors associated with a modulation of fibrin clot structure and resistance to fibrinolysis in patients with protein C ...

Call: OPUS 28 , Panel: NZ5

Principal investigator: dr hab. Michał Tomasz Ząbczyk

Krakowski Szpital Specjalistyczny im. Jana Pawła II

Selective autophagy-mediated protein degradation as a potential therapeutic strategy for the treatment of inflammatory c...

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Monika Emilia Marcinkowska

Uniwersytet Jagielloński

Human exosomes as natural carriers of protein kinase CK2 inhibitors and degraders in targeted anticancer therapy.

Call: OPUS 28 (LAP) , Panel: NZ5

Principal investigator: dr hab. Patrycja Joanna Wińska

Politechnika Warszawska

A comprehensive structural and functional analysis of toxic RNA-protein interactions for better understanding and therap...

Call: OPUS 28 (LAP) , Panel: NZ5

Principal investigator: dr hab. Agnieszka Ludmiła Kiliszek

Instytut Chemii Bioorganicznej PAN

Unlocking the unused capacity of bacterial metabolism through the rational design of substrate transporters

Call: OPUS 28 (LAP) , Panel: NZ1

Principal investigator: dr hab. Jan Brezovsky

Uniwersytet im. Adama Mickiewicza w Poznaniu

Elemental signatures in fossil and modern otoliths: Proxies for biomineralizing protein functionality and diagenetic alt...

Call: OPUS 28 , Panel: ST10

Principal investigator: prof. Jarosław Hubert Stolarski

Instytut Paleobiologii Polskiej Akademii Nauk

From Static to Dynamic: Integrating Glycan Dynamics into Structural Biology

Call: SONATA BIS 14 , Panel: NZ1

Principal investigator: dr Mateusz Sikora

Uniwersytet Jagielloński

Canonical and non-canonical roles of DDK in oncogenesis: a cornerstone for the development of novel, potent anticancer t...

Call: SONATA BIS 14 , Panel: NZ3

Principal investigator: dr Jan Marian Suski

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Unravelling the Mechanisms of Gene Expression of Hepatitis A Virus

Call: SONATA BIS 14 , Panel: NZ6

Principal investigator: dr Stefan Bresson

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Characterization of ANGPTL4 production in the peritoneum

Call: PRELUDIUM 23 , Panel: NZ4

Principal investigator: Joanna Marta Żuraszek-Szymańska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Changes in protein citrullination profile and chromatin structure induced by peptidyl-arginine deiminases activity and t...

Call: PRELUDIUM 23 , Panel: NZ3

Principal investigator: dr Oskar Kazimierz Ciesielski

Uniwersytet Łódzki

Development and testing of innovative low-processed clay building composites modified with a protein-based biopolymer

Call: OPUS 27 , Panel: ST8

Principal investigator: dr Przemysław Brzyski

Politechnika Lubelska

Deciphering the Molecular Mechanism of Queuosinylation of Human tRNA: Structural and Functional Analyses of the QTRT1/2 ...

Call: PRELUDIUM 23 , Panel: NZ1

Principal investigator: Igor Kaczmarczyk

Uniwersytet Jagielloński

Macro-to-Micro: Fabrication of synthetic receptor based microsensors for certain protein sensing

Call: OPUS 27 , Panel: ST11

Principal investigator: dr hab. Piyush Sindhu Sharma

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Structural basis for key protein–protein interactions of deoxyhypusine hydroxylase

Call: PRELUDIUM 23 , Panel: NZ1

Principal investigator: Daniel Zakaszewski

Uniwersytet Jagielloński

Function of Angiomotin-like 2 (AMOTL2) protein in cortex development.

Call: PRELUDIUM 23 , Panel: NZ3

Principal investigator: Ila Joshi

Sieć Badawcza ŁUKASIEWICZ - PORT Polski Ośrodek Rozwoju Technologii

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański