Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular basis of carnitine transporters OCTN2 and ATB(0,+) trafficking to plasma membrane of astrocytes: The role of protein-protein interactions

2012/07/B/NZ3/00225

Keywords:

carnitine astrocytes transporting proteins protein complexes

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_5: Molecular neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Katarzyna Nałęcz 

Number of co-investigators in the project: 4

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 590 000 PLN

Project start date (Y-m-d): 2013-07-01

Project end date (Y-m-d): 2016-12-31

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Transiluminator UV (8 000 PLN)
  2. Aparat do elektroforezy.
  3. Spektrofotometr do pomiarów w zakresie UV i światła widzialnego (do co najmniej 750 nm) z drukarką (45 400 PLN)
  4. pH-metr z elektorodą (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. Protein phosphatase PP2A – a novel interacting partner of carnitine transporter OCTN2 (SLC22A5) in rat astrocytes
    Authors:
    Juraszek B., Nałęcz K. A.
    Academic press:
    Journal of Neurochemistry (rok: 2016, tom: 139, strony: 537-551), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jnc.13777 - link to the publication
  2. Karnityna – mitochondria i nie tylko
    Authors:
    Nałęcz K.A., Nałęcz M.J.
    Academic press:
    Postępy Biochemii (rok: 2016, tom: 62, strony: 85-93), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    Brak - link to the publication
  3. Solute carriers in the blood-brain barrier: Safety in abundance
    Authors:
    Nałęcz K.A.
    Academic press:
    Neurochemical Research (rok: 2017, tom: 42, strony: 795-809), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-016-2030-x - link to the publication
  4. Tight junction protein ZO-1 controls organic cation/carnitine transporter OCTN2 (SLC22A5) in a protein kinase C - dependent way
    Authors:
    Jurkiewicz D., Michalec K., Skowronek K., Nałęcz K. A.
    Academic press:
    BBA - Molecular Cell Research (rok: 2017, tom: 1864, strony: 797-805), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2017.02.014 - link to the publication
  1. Organic cation/carnitine transporter (OCTN2) interaction proteome in rat astrocytes: Role of phosphatase PP2A
    Authors:
    Nałęcz K.A., Juraszek B.
    Conference:
    European Society for Neurochemistry Biannual Conference:Molecular Mechanisms of Regulation in the Nervous System (rok: 2015, ), Wydawca: Springer (SpringerPlus)
    Data:
    konferencja 14-17 czerwca
    Status:
    Published
    DOI:
    link to the publication
  2. Organic cation/carnitine transporter OCTN2 is indirectly regulated by Protein kinase C affecting transporter interacting partners
    Authors:
    Nałęcz K.A., Juraszek B., Michalec K, Jurkiewicz D, Skowronek K
    Conference:
    14th International Congress on Amino Acids, Peptides and Proteins (rok: 2015, ), Wydawca: Springer
    Data:
    konferencja 2-7 sierpnia
    Status:
    Published
    DOI:
    link to the publication
  3. Direct interaction between PDZ protein ZO-1 and carnitine transporter OCTN2 regulates transport activity
    Authors:
    Jurkiewicz D., Skowronek K., Nałęcz K.A.
    Conference:
    EMBO Young Scientist's Forum (rok: 2016, ), Wydawca: organizatorzy
    Data:
    konferencja 1-2 września
    Status:
    Published
    DOI:
    link to the publication
  4. The role of PDZ binding domain of a novel organic cation/carnitine transporter (OCTN2)
    Authors:
    Jurkiewicz D, Skowronek K, Nałęcz K.A.
    Conference:
    17th European Congress on Biotechnology (rok: 2016, ), Wydawca: Elsevier
    Data:
    konferencja 3-6 lipca
    Status:
    Published
    DOI:
    link to the publication
  5. Cross-talk of signaling and energy-delivering processes in astrocytes: interaction of carnitine transporter OCTN2 with phosphatase PP2A
    Authors:
    Juraszek B., Nałęcz K.A.
    Conference:
    XII European Meeting on Glial Cells in Health and Disease (rok: 2015, ), Wydawca: Wiley
    Data:
    konferencja 15-18 lipca
    Status:
    Published
    DOI:
    link to the publication
  6. Trafficking of the amino acid transporter B0,+ (ATB0,+) to the plasma membrane
    Authors:
    Samluk L., Susic S., Freissmuth M., Nałecz K.A..
    Conference:
    FEBS EMBO 2014 Conference, Paris, France (rok: 2014, ), Wydawca: FEBS J. 281 (Suppl. 1)
    Data:
    konferencja 30.08-4.09.2014
    Status:
    Published

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