Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of prion protein in amyloidogenesis and neurotoxicity of Tau protein

2016/21/B/NZ4/00181

Keywords:

prion protein Tau protein tauopathies Alzheimer's disease protein aggregation

Descriptors:

  • NZ1_2: Biochemistry
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Nieznański 

Number of co-investigators in the project: 4

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 880 200 PLN

Project start date (Y-m-d): 2017-02-16

Project end date (Y-m-d): 2022-02-15

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termostatowany czytnik płytek do pomiarów fluorymetrycznych, z możliwością wytrząsania. (100 000 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (1)
  1. Neurotoxicity of oligomers of phosphorylated Tau protein carrying tauopathy-associated mutation is inhibited by prion protein
    Authors:
    Hanna Nieznanska, Solomiia Boyko, Robert Dec, Maria Jolanta Redowicz, Wojciech Dzwolak, Krzysztof Nieznanski
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2021, tom: 1867, strony: 166209), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2021.166209 - link to the publication
  1. Interaction between prion protein and tau protein
    Authors:
    Solomiia Boyko, Hanna Nieznanska, Krzysztof Nieznanski
    Conference:
    VII International Conference Aspects of Neuroscience (rok: 2017, ), Wydawca: Uniwersytet Warszawski
    Data:
    konferencja 24-26 listopada
    Status:
    Published

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