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Information on the principal investigator and host institution

Information of the project and the call

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Physicochemical and structural study on the influence of charged amino acidic residues presence in the sequence in stabilization of beta-hairpin structure in proteins

2011/01/D/ST4/04497

Keywords:

beta hairpins protein1E0L protein 1IGD conformational study potentiometric titration

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST4_15: Colloid chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Makowska 

Number of co-investigators in the project: 4

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 196 150 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2014-11-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer (4 000 PLN)
  2. Przystawka do DSC (5 000 PLN)
  3. Dysk przenośny (500 PLN)
  4. Drukarka laserowa (1 000 PLN)
  5. Notebook do zestawu do miareczkowania oraz oprogramowanie (Program Cerkolab) (4 000 PLN)
  6. Termostat z chłodzeniem Advanced 7L Low-Prof. (5 925 PLN)
  7. Zestaw komputerowy.
  8. Zestaw pomiarowy do miareczkowania potencjometrycznego Mikrotitrator CLS (Cerko) (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Book publications / chapters in book publications (2)
  1. Influence of the length of the alanine spacer on the acidic-basic properties of the Ac- Lys-(Ala)n-Lys-NH2 peptides (n=0, 1, 2,.., 5)
    Authors:
    Joanna Makowska, Adam Liwo, Lech Chmurzyński, Harold A. Scheraga
    Academic press:
    Journal of Solution Chemistry (rok: 2012, tom: 41, strony: 1738–1746), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10953-012-9903-7 - link to the publication
  2. Studies of conformational preferences of derivatives fragments of protein G (1IGD) using temperature dependent potentiometric titration methodology
    Authors:
    Joanna Makowska, Dorota Uber, Dagmara Lubowiecka, Lech Chmurzyński
    Academic press:
    The Journal of Chemical Thermodynamics (rok: 2014, tom: 70, strony: 88-94), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.029 - link to the publication
  3. Thermodynamics of sodium dodecyl sulphate (SDS) micellization in the presence of some biologically relevant pH buffers
    Authors:
    J. Makowska, D. Wyrzykowski, B. Pilarski, L. Chmurzyński
    Academic press:
    Journal of Thermal Analysis and Calorimetry (rok: 2014, tom: -, strony: -), Wydawca: Springer
    Status:
    Submitted
    DOI:
    - - link to the publication
  4. Like-Charged Residues at the Ends of Oligoalanine Sequences Might Induce a Chain Reversal
    Authors:
    Joanna Makowska, Adam Liwo, Wioletta Żmudzińska, Agnieszka Lewandowska, Lech Chmurzyński, Harold A. Scheraga
    Academic press:
    Biopolymers (rok: 2012, tom: 97, strony: 240-249), Wydawca: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1002/bip.22013 - link to the publication
  5. Preliminary Studies on Trigonelline as Potential Anti-Alzheimer Disease Agent: Determination by Hydrophilic Interaction Liquid Chromatography and Modeling of Interactions with Beta-Amyloid
    Authors:
    Joanna Makowska, Damian Szczęsny, Agnieszka Lichucka, Artur Giełdoń, Lech Chmurzyński, Roman Kaliszan
    Academic press:
    Journal of Chromatography B (rok: 2014, tom: 1, strony: 101-104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2013.12.001 - link to the publication
  6. Thermodynamics of the protonation equilibria of two fragments of N-terminal beta-hairpin of FPB28 WW domain
    Authors:
    Joanna Makowska, Dorota Uber, and Lech Chmurzynski
    Academic press:
    The Journal of Physical Chemistry B (rok: 2012, tom: 116, strony: 653-659), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jp209844v - link to the publication
  7. A Study of the Influence of Charged Residues on b-Hairpin Formation by Nuclear Magnetic Resonance and Molecular Dynamics
    Authors:
    J. Makowska, W. Żmudzińska, D. Uber, L. Chmurzyński
    Academic press:
    The Protein Journal (rok: 2014, tom: 33, strony: 525–535), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10930-014-9585-7 - link to the publication
  8. Thermodynamical studies of the example peptide containing metaaminobenzoic acid (MABA) which promotes bends in proteins
    Authors:
    J. Makowska, D. Uber, L. Chmurzyński
    Academic press:
    Journal of Solution Chemistry (rok: 2014, tom: -, strony: -), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  9. Investigations of copper(II) complexation by fragments of the FBP28 protein using isothermal titration (ITC) and differential scanning calorimetry (DSC)
    Authors:
    J. Makowska, D. Wyrzykowski, P. Hirniak, D. Uber, L. Chmurzyński
    Academic press:
    Journal of Thermal Analysis and Calorimetry (rok: 2014, tom: -, strony: -), Wydawca: Springer
    Status:
    Submitted
    DOI:
    - - link to the publication
  1. Wpływ naładowanych reszt aminokwasowych na strukturę beta w białkach
    Authors:
    Dorota Uber, Joanna Makowska, Lech Chmurzyński
    Book:
    Na pograniczu chemii i biologii (rok: 2013, tom: XXXI, strony: 137-145), Wydawca: Wydawnictwo naukowe UAM
    Status:
    Published
  2. Conformational analysis of the fragment of the human Pin1 WW domain: the influence of charged amino-acid residues on the β-hairpin structure
    Authors:
    J. Makowska, D. Uber, W. Żmudzińska, L. Chmurzyński
    Book:
    TASK Quarterly - CBSB 2014 special issue (rok: 2014, tom: 18, strony: 217-223), Wydawca: Academic Computer Centre in Gdansk
    Status:
    Published

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