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Physicochemical stabilization of Active Pharmaceutical Ingredients and Proteins using modified and bicyclic sugars. Searching for new forms of saccharides in plant materials.

2013/09/D/NZ7/04194

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ7_16: Inne zagadnienia pokrewne

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Śląski Uniwersytet Medyczny w Katowicach, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Voivodeship: śląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Ewa Iwona Ozimina-Kamińska

Number of co-investigators in the project: 5

Call

SONATA 5 – announced on 2013-03-15

Amount awarded
518 360 PLN
Project start date
2014-02-24
Project end date
2017-02-23
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Nowoczesny system chromatograficzny z detektorami: refraktometrycznym i UV-VIS. Cost: 210 000 PLN

Information in the final report

Publication in academic press/journals (14)

  1. Impact of low molecular weight excipient octaacetylmaltose on the liquid crystalline ordering and molecular dynamics in the supercooled liquid and glassy state of itraconazole

    Authors:
    E. Kaminska, M. Tarnacka, K. Kolodziejczyk, M. Dulski, D. Zakowiecki, L. Hawelek, K. Adrjanowicz, M. Zych, G. Garbacz and K. Kaminski
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (year: 2014, volume: 88, pages: 1094-1104), Publisher: Elsevier Science
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2014.10.002 – link to the publication

  2. Enhancement of the Physical Stability of Amorphous Indomethacin by Mixing it with Octaacetylmaltose. Inter and Intra Molecular Studies.

    Authors:
    E. Kaminska, K. Adrjanowicz, D. Zakowiecki, B. Milanowski, M. Tarnacka, L. Hawelek, M. Dulski, J. Pilch, W. Smolka, I. Kaczmarczyk-Sedlak, K. Kaminski
    Academic press:
    Pharmaceutical Research (year: 2014, volume: 31, pages: 2887-2903), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11095-014-1385-4 – link to the publication

  3. Decoupling Between Interfacial and Core Molecular Dynamics of Salol n 2D Confinement

    Authors:
    K. Adrjanowicz, K. Kołodziejczyk, W. K. Kipnusu, M. Tarnacka, E. U. Mapesa, E. Kaminska, S. Pawlus, K. Kaminski, M. Paluch,
    Academic press:
    Journal of Physical Chemistry C (year: 2015, volume: 119, pages: 14366–14374), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.5b01391 – link to the publication

  4. Thermodynamic Scaling of Molecular Dynamics in Supercooled Liquid State of Pharmaceuticals: Itraconazole and Ketoconazole

    Authors:
    M. Tarnacka, O. Madejczyk, K. Adrjanowicz, J. Pionteck, E. Kaminska, K. Kaminski, M. Paluch
    Academic press:
    Journal of Chemical Physics (year: 2015, volume: 142, pages: 224507), Publisher: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4921985 – link to the publication

  5. The Improvement of the Dissolution Rate of Ziprasidone Free Base from Solid Oral Formulations

    Authors:
    D. Zakowiecki, K. Cal, K. Kaminski, K. Adrjanowicz, L. Swinder, E. Kaminska, G. Garbacz
    Academic press:
    AAPS PharmSciTech (year: 2015, volume: 16, pages: 922-933), Publisher: Springer
    Status:
    Published
    DOI:
    10.1208/s12249-015-0285-1 – link to the publication

  6. The impact of inter and intramolecular interactions on physical stability of Indomethacin dispersed in acetylated saccharides

    Authors:
    E. Kaminska, K. Adrjanowicz, M. Tarnacka, K. Kolodziejczyk, M. Dulski, E. U. Mapesa, D. Zakowiecki, L. Hawelek, I. Kaczmarczyk-Sedlak and K. Kaminski
    Academic press:
    Molecular Pharmaceutics (year: 2014, volume: 11, pages: 2935-2947), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp500286b – link to the publication

  7. Studying of crystal growth and overall crystallization of naproxen from binary mixtures

    Authors:
    E. Kaminska, O. Madejczyk, M. Tarnacka, K. Jurkiewicz, K. Kaminski, M. Paluch
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (year: 2017, volume: 113, pages: 75-87), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2016.12.014 – link to the publication

  8. Crystallization Kinetics under Confinement. Manipulation of the Crystalline Form of Salol by Varying Pore Diameter

    Authors:
    Karolina Kołodziejczyk, Magdalena Tarnacka, Ewa Kamińska, Mateusz Dulski, Kamil Kamiński, Marian Paluch
    Academic press:
    Crystal Growth & Design (year: 2016, volume: 16, pages: 1218−1227), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.cgd.5b01181 – link to the publication

  9. Molecular dynamics of itraconazole confined in thin supported layers

    Authors:
    E. U. Mapesa, M. Tarnacka, E. Kaminska, K.Adrjanowicz, M. Dulski, W. Kossack, M. Tress, W. K. Kipnusu, K. Kaminski, F. Kremer
    Academic press:
    RSC Advances (year: 2014, volume: 4, pages: 28432-28438), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c4ra01544d – link to the publication

  10. Observation of the nearly constant loss in super rigid saccharides: in search of a hidden crossover in dynamics deep in the glassy state

    Authors:
    Ewa Kaminska, Magdalena Tarnacka, Olga Madejczyk, Anna Chrobok, Kamil Kaminski, Marian Paluch
    Academic press:
    Physical Chemistry Chemical Physics (year: 2016, volume: 18, pages: 8901-8910), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5cp07948a – link to the publication

  11. The kinetics of mutarotation in L-fucose as monitored by dielectric and infrared spectroscopy

    Authors:
    W. Kossack, W. K. Kipnusu, M. Dulski, K.Adrjanowicz, O. Madejczyk, E. Kaminska, E. U. Mapesa, M. Tress, K. Kaminski, F. Kremer
    Academic press:
    Journal of Chemical Physics (year: 2014, volume: 140, pages: 215101), Publisher: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4880718 – link to the publication

  12. High pressure dielectric studies on the structural and orientational glass

    Authors:
    E. Kaminska, M. Tarnacka, K. Jurkiewicz, K. Kaminski, M. Paluch
    Academic press:
    Journal of Chemical Physics (year: 2016, volume: 144, pages: 054503, p. 1-11), Publisher: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4940776 – link to the publication

  13. Changes in Dynamics of the Glass-forming Pharmaceutical Nifedipine in Binary Mixtures with Octaacetylmaltose

    Authors:
    E. Kaminska, M. Tarnacka, K. Kaminski, K. L. Ngai, M. Paluch,
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (year: 2015, volume: 97, pages: 185-191), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2015.09.010. – link to the publication

  14. Studying the Impact of Modified Saccharides on the Molecular Dynamics and Crystallization Tendencies of Model API Nifedipine

    Authors:
    E. Kaminska, M. Tarnacka, P. Wlodarczyk, K. Jurkiewicz, K. Kolodziejczyk, M. Dulski, D. Haznar-Garbacz, L. Hawelek, K. Kaminski, A. Wlodarczyk, M. Paluch
    Academic press:
    Molecular Pharmaceutics (year: 2015, volume: 12, pages: 3007-3019), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00271 – link to the publication

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