Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Physicochemical stabilization of Active Pharmaceutical Ingredients and Proteins using modified and bicyclic sugars. Searching for new forms of saccharides in plant materials.

2013/09/D/NZ7/04194

Keywords:

saccharides High Performance Liquid Chromatography (HPLC) plant materials binary mixtures active pharmaceutical ingredients proteins

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Śląski Uniwersytet Medyczny w Katowicach, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Ozimina-Kamińska 

Number of co-investigators in the project: 5

Call: SONATA 5 - announced on 2013-03-15

Amount awarded: 518 360 PLN

Project start date (Y-m-d): 2014-02-24

Project end date (Y-m-d): 2017-02-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Nowoczesny system chromatograficzny z detektorami: refraktometrycznym i UV-VIS (210 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  1. Changes in Dynamics of the Glass-forming Pharmaceutical Nifedipine in Binary Mixtures with Octaacetylmaltose
    Authors:
    E. Kaminska, M. Tarnacka, K. Kaminski, K. L. Ngai, M. Paluch,
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (rok: 2015, tom: 97, strony: 185-191), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10. - link to the publication
  2. Enhancement of the Physical Stability of Amorphous Indomethacin by Mixing it with Octaacetylmaltose. Inter and Intra Molecular Studies.
    Authors:
    E. Kaminska, K. Adrjanowicz, D. Zakowiecki, B. Milanowski, M. Tarnacka, L. Hawelek, M. Dulski, J. Pilch, W. Smolka, I. Kaczmarczyk-Sedlak, K. Kaminski
    Academic press:
    Pharmaceutical Research (rok: 2014, tom: 31, strony: 2887-2903), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11095-014-1385-4 - link to the publication
  3. Studying the Impact of Modified Saccharides on the Molecular Dynamics and Crystallization Tendencies of Model API Nifedipine
    Authors:
    E. Kaminska, M. Tarnacka, P. Wlodarczyk, K. Jurkiewicz, K. Kolodziejczyk, M. Dulski, D. Haznar-Garbacz, L. Hawelek, K. Kaminski, A. Wlodarczyk, M. Paluch
    Academic press:
    Molecular Pharmaceutics (rok: 2015, tom: 12, strony: 3007-3019), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00271 - link to the publication
  4. Impact of low molecular weight excipient octaacetylmaltose on the liquid crystalline ordering and molecular dynamics in the supercooled liquid and glassy state of itraconazole
    Authors:
    E. Kaminska, M. Tarnacka, K. Kolodziejczyk, M. Dulski, D. Zakowiecki, L. Hawelek, K. Adrjanowicz, M. Zych, G. Garbacz and K. Kaminski
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (rok: 2014, tom: 88, strony: 1094-1104), Wydawca: Elsevier Science
    Status:
    Published
    DOI:
    10.002 - link to the publication
  5. Molecular dynamics of itraconazole confined in thin supported layers
    Authors:
    E. U. Mapesa, M. Tarnacka, E. Kaminska, K.Adrjanowicz, M. Dulski, W. Kossack, M. Tress, W. K. Kipnusu, K. Kaminski, F. Kremer
    Academic press:
    RSC Advances (rok: 2014, tom: 4, strony: 28432-28438), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c4ra01544d - link to the publication
  6. Observation of the nearly constant loss in super rigid saccharides: in search of a hidden crossover in dynamics deep in the glassy state
    Authors:
    Ewa Kaminska, Magdalena Tarnacka, Olga Madejczyk, Anna Chrobok, Kamil Kaminski, Marian Paluch
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2016, tom: 18, strony: 8901-8910), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5cp07948a - link to the publication
  7. Studying of crystal growth and overall crystallization of naproxen from binary mixtures
    Authors:
    E. Kaminska, O. Madejczyk, M. Tarnacka, K. Jurkiewicz, K. Kaminski, M. Paluch
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (rok: 2017, tom: 113, strony: 75-87), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2016.12.014 - link to the publication
  8. Crystallization Kinetics under Confinement. Manipulation of the Crystalline Form of Salol by Varying Pore Diameter
    Authors:
    Karolina Kołodziejczyk, Magdalena Tarnacka, Ewa Kamińska, Mateusz Dulski, Kamil Kamiński, Marian Paluch
    Academic press:
    Crystal Growth & Design (rok: 2016, tom: 16, strony: 1218−1227), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.cgd.5b01181 - link to the publication
  9. Decoupling Between Interfacial and Core Molecular Dynamics of Salol n 2D Confinement
    Authors:
    K. Adrjanowicz, K. Kołodziejczyk, W. K. Kipnusu, M. Tarnacka, E. U. Mapesa, E. Kaminska, S. Pawlus, K. Kaminski, M. Paluch,
    Academic press:
    Journal of Physical Chemistry C (rok: 2015, tom: 119, strony: 14366–14374), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.5b01391 - link to the publication
  10. The kinetics of mutarotation in L-fucose as monitored by dielectric and infrared spectroscopy
    Authors:
    W. Kossack, W. K. Kipnusu, M. Dulski, K.Adrjanowicz, O. Madejczyk, E. Kaminska, E. U. Mapesa, M. Tress, K. Kaminski, F. Kremer
    Academic press:
    Journal of Chemical Physics (rok: 2014, tom: 140, strony: 215101), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4880718 - link to the publication
  11. Thermodynamic Scaling of Molecular Dynamics in Supercooled Liquid State of Pharmaceuticals: Itraconazole and Ketoconazole
    Authors:
    M. Tarnacka, O. Madejczyk, K. Adrjanowicz, J. Pionteck, E. Kaminska, K. Kaminski, M. Paluch
    Academic press:
    Journal of Chemical Physics (rok: 2015, tom: 142, strony: 224507), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4921985 - link to the publication
  12. High pressure dielectric studies on the structural and orientational glass
    Authors:
    E. Kaminska, M. Tarnacka, K. Jurkiewicz, K. Kaminski, M. Paluch
    Academic press:
    Journal of Chemical Physics (rok: 2016, tom: 144, strony: 054503, p. 1-11), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4940776 - link to the publication
  13. The Improvement of the Dissolution Rate of Ziprasidone Free Base from Solid Oral Formulations
    Authors:
    D. Zakowiecki, K. Cal, K. Kaminski, K. Adrjanowicz, L. Swinder, E. Kaminska, G. Garbacz
    Academic press:
    AAPS PharmSciTech (rok: 2015, tom: 16, strony: 922-933), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1208/s12249-015-0285-1 - link to the publication
  14. The impact of inter and intramolecular interactions on physical stability of Indomethacin dispersed in acetylated saccharides
    Authors:
    E. Kaminska, K. Adrjanowicz, M. Tarnacka, K. Kolodziejczyk, M. Dulski, E. U. Mapesa, D. Zakowiecki, L. Hawelek, I. Kaczmarczyk-Sedlak and K. Kaminski
    Academic press:
    Molecular Pharmaceutics (rok: 2014, tom: 11, strony: 2935-2947), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/mp500286b - link to the publication

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