Projects funded by the NCN


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56 projects found matching your search criteria :

  1. The involvement of IL-10 in the activation of the suppression mechanism utilized by myeloid-derived suppressor cells - d...

    Call: PRELUDIUM 8 , Panel: NZ4

    Principal investigator: Natalia Anger

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

  2. Identification of new, clinically relevant genetic and epigenetic aberrations by next-generation sequencing in chronic m...

    Call: HARMONIA 6 , Panel: NZ5

    Principal investigator: dr Tomasz Stokłosa

    Warszawski Uniwersytet Medyczny, Wydział Lekarski

  3. Integrity of E3 ubiquitin ligase complex as a biomarker of response to treatment with immunomodulatory drugs in patients...

    Call: OPUS 7 , Panel: NZ5

    Principal investigator: dr hab. Ewa Lech-Marańda

    Instytut Hematologii i Transfuzjologii

  4. Characteristics of neuropilin-1 (NRP1) as a target of antiangiogenic activity of immunomodulatory drugs in multiple myel...

    Call: OPUS 7 , Panel: NZ6

    Principal investigator: prof. Krzysztof Giannopoulos

    Uniwersytet Medyczny w Lublinie, II Wydział Lekarski z Oddziałem Anglojęzycznym

  5. Mechanism of SYK-mediated suppression of differentiation and apoptosis in acute myeloid leukemia (AML)

    Call: PRELUDIUM 6 , Panel: NZ5

    Principal investigator: dr Anna Polak

    Instytut Hematologii i Transfuzjologii

  6. The regulation of vitamin D receptor expression by retinoids

    Call: PRELUDIUM 6 , Panel: NZ3

    Principal investigator: Aleksandra Marchwicka

    Uniwersytet Wrocławski, Wydział Biotechnologii

  7. Transcriptional-epigenetic role of poly(ADP-ribose) polymerase-1 in expression of pro-inflammatory mediators controlled ...

    Call: SONATA 6 , Panel: NZ2

    Principal investigator: dr Agnieszka Robaszkiewicz

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  8. Inhibition of p21-Activated Kinase (PAK) as a new molecular target in the treatment of chronic myeloid leukemia (CML)

    Call: OPUS 6 , Panel: NZ7

    Principal investigator: dr hab. Sylwia Flis

    Narodowy Instytut Leków

  9. The role of nucelophosmin-1 exon 12 abnormalities in acute myeloid leukemias and myelodyplastic syndrome

    Call: HARMONIA 5 , Panel: NZ5

    Principal investigator: dr hab. Krzysztof Giannopoulos

    Uniwersytet Medyczny w Lublinie, II Wydział Lekarski z Oddziałem Anglojęzycznym

  10. Analysis of the effect of the DIS3 mutations on the viability, development and tumor formation in mice

    Call: HARMONIA 5 , Panel: NZ4

    Principal investigator: dr hab. Andrzej Dziembowski

    Instytut Biochemii i Biofizyki PAN

  11. Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

    Call: SONATA BIS 3 , Panel: NZ5

    Principal investigator: prof. Dominika Nowis

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  12. The influence of hypoxia on functional features of multiple myeloma cells

    Call: PRELUDIUM 5 , Panel: NZ1

    Principal investigator: dr Kinga Kocemba

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum, Wydział Lekarski

  13. Analysis of oligodendrocyte differentiation and maturation of St8sia2 knockout mice - a model of polysialylation deficie...

    Call: PRELUDIUM 5 , Panel: NZ3

    Principal investigator: dr Łukasz Szewczyk

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  14. Lipid antigens as a target for autoimmune attack in multiple sclerosis.

    Call: HARMONIA 4 , Panel: NZ3

    Principal investigator: dr Maria Podbielska

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

  15. Investigation of the role of ficolins in anti-microbial defense in patients suffering from acute myeloid leukaemia, unde...

    Call: PRELUDIUM 4 , Panel: NZ6

    Principal investigator: Anna Sokołowska

    Instytut Biologii Medycznej PAN

  16. Role of Myeloid Derived Suppressor Cells in Heligmosomoides polygyrus infection in mice

    Call: PRELUDIUM 3 , Panel: NZ6

    Principal investigator: Klaudia Brodaczewska

    Uniwersytet Warszawski, Wydział Biologii

  17. Role of myeloid dendritic cells in immune response polarization in resistant (C57BL/6) and susceptible (BALB/c) mice dur...

    Call: SONATA 3 , Panel: NZ6

    Principal investigator: dr Lidia Szulc-Dąbrowska

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

  18. The novel role of CD44 protein in the bone marrow microenvironment-mediated metabolic remodeling of chronic myeloid leuk...

    Call: PRELUDIUM 22 , Panel: NZ3

    Principal investigator: Laura Turos-Korgul

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  19. Differences in the glycoproteomic profile of acute myeloid leukemia (AML) between cytogenetic and risk groups according ...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Tomasz Pieńkowski

    Uniwersytet Medyczny w Białymstoku

  20. EBI2 receptor as a new myelin repair therapy in multiple sclerosis.

    Call: SONATA 18 , Panel: NZ3

    Principal investigator: dr Aleksandra Rutkowska

    Gdański Uniwersytet Medyczny, Centrum Chorób Mózgu

  21. Development and differentiation of 'early-stage" myeloid-derived suppressor cells (e-MDSCs) in colorectal cancer – the r...

    Call: OPUS 24 , Panel: NZ6

    Principal investigator: dr hab. Jarosław Baran

    Uniwersytet Jagielloński, Collegium Medicum

  22. Investigating the role of fibroblast growth factor receptors and STAT transcription factors in the targeted therapy of a...

    Call: PRELUDIUM BIS 4 , Panel: NZ5

    Principal investigator: prof. Ewa Marcinkowska

    Uniwersytet Wrocławski, Wydział Biotechnologii

  23. The role of the gut microbiota in the pathogenesis of plasma cell dyscrasias

    Call: PRELUDIUM 21 , Panel: NZ6

    Principal investigator: Marcin Jasiński

    Warszawski Uniwersytet Medyczny

  24. Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr hab. Carlo Vascotto

    Instytut Hematologii i Transfuzjologii

  25. Raman reporters as a tool to evaluate in vitro myeloid precursors differentiation.

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Adriana Adamczyk

    Uniwersytet Jagielloński, Wydział Chemii

  26. Mechanisms of generation of myeloid-derived suppressor cells of monocyte origin (Mo-MDSCs) by extracellular vesicles fro...

    Call: PRELUDIUM 20 , Panel: NZ6

    Principal investigator: Izabela Siemińska

    Uniwersytet Jagielloński, Collegium Medicum

  27. Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

    Call: OPUS 21 , Panel: NZ5

    Principal investigator: dr hab. Katarzyna Piwocka

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  28. Uracil in DNA and aberrant DNA methylation/hydroxymethylation as a new biomarkers of multiple myeloma development? A sea...

    Call: OPUS 20 , Panel: NZ5

    Principal investigator: prof. Ryszard Oliński

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

  29. The proangiogenic functions of PIM kinases in plasma cell myeloma

    Call: ETIUDA 8 , Panel: NZ5

    Principal investigator: Filip Garbicz

    Instytut Hematologii i Transfuzjologii

  30. The alterations in oligodendrocyte functioning in pathogenesisis of white matter injury resulting from neonaal asphyxia.

    Call: ETIUDA 8 , Panel: NZ4

    Principal investigator: Justyna Janowska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  31. Gankyrin protein as a new potential therapeutic target in multiple myeloma

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: dr Irena Misiewicz-Krzemińska

    Instytut Hematologii i Transfuzjologii

  32. Epigenetic effect on therapeutic activities of all-trans-retinoic acid in acute myeloid leukemia

    Call: OPUS 17 , Panel: NZ5

    Principal investigator: prof. Arthur Zelent

    Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego

  33. Role of the human RNA exosome catalytic subunit DIS3 in multiple myeloma pathogenesis and cell physiology.

    Call: MAESTRO 1 , Panel: NZ1

    Principal investigator: prof. Andrzej Dziembowski

    Uniwersytet Warszawski, Wydział Biologii

  34. Identification, phenotypic and functional analysis of myeloid-derived suppressor cells in ovarian cancer in terms of the...

    Call: ETIUDA 7 , Panel: NZ5

    Principal investigator: dr Karolina Okła

    Uniwersytet Medyczny w Lublinie, Wydział Lekarski

  35. How dysfunction in the nuclear, RNA degrading enzyme DIS3 leads to mitotic defects creating a possible therapeutic strat...

    Call: SONATINA 3 , Panel: NZ2

    Principal investigator: dr Tomasz Kuliński

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  36. Immunological and molecular characteisitics of chronic myeloid leukemia patients after stopping imatinib

    Call: OPUS 16 , Panel: NZ6

    Principal investigator: prof. Krzysztof Giannopoulos

    Uniwersytet Medyczny w Lublinie, Wydział Lekarski

  37. The role of PIM kinases in the vascular niche of multiple myeloma

    Call: PRELUDIUM 16 , Panel: NZ5

    Principal investigator: Filip Garbicz

    Instytut Hematologii i Transfuzjologii

  38. Multi-omics profiling of circulating myeloid-derived suppressor cells (cMDSCs) in epithelial ovarian cancer

    Call: PRELUDIUM 16 , Panel: NZ2

    Principal investigator: dr Karolina Okła

    Uniwersytet Medyczny w Lublinie, Wydział Lekarski

  39. Deciphering molecular mechanism of CDK8 kinase inhibitors action in acute myeloid leukemia

    Call: SONATA BIS 8 , Panel: NZ2

    Principal investigator: dr hab. Michał Mikula

    Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

  40. Tracing the roots of leukemia - how preleukemic hematopoietic stem cells contribute to acute lymphoid and myeloid leukem...

    Call: HARMONIA 10 , Panel: NZ5

    Principal investigator: dr Krzysztof Szade

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  41. Determining the role of basigin in multiple myeloma and acute myeloid leukaemia development

    Call: PRELUDIUM 15 , Panel: NZ5

    Principal investigator: Piotr Łacina

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

  42. Association of TXNDC5 and calreticulin with decreased ER stress, allowing resistant multiple myeloma cells to by-pass pr...

    Call: PRELUDIUM 15 , Panel: NZ5

    Principal investigator: Tadeusz Kubicki

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

  43. Cognitive functioning of patients with multiple myeloma and biological factors as well as psychosocial variables shaping...

    Call: PRELUDIUM 14 , Panel: HS6

    Principal investigator: Magdalena Bury-Kamińska

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Pedagogiki i Psychologii

  44. The role of Fam46C in B cell phisiology

    Call: OPUS 14 , Panel: NZ2

    Principal investigator: dr Seweryn Mroczek

    Uniwersytet Warszawski, Wydział Biologii

  45. Linking stress response with genomic instability in chronic myeloid leukaemia cells; role of the PERK-eIF2α phosphorylat...

    Call: OPUS 1 , Panel: NZ3

    Principal investigator: dr hab. Katarzyna Piwocka

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  46. Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome i...

    Call: OPUS 13 , Panel: NZ6

    Principal investigator: prof. Jakub Gołąb

    Warszawski Uniwersytet Medyczny, Wydział Lekarski

  47. Proteomic analysis of myeloma plasma cells to determine proteins and pathways involved in acquired resistance to proteas...

    Call: OPUS 13 , Panel: NZ5

    Principal investigator: dr hab. Dominik Dytfeld

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

  48. Evaluation of primary and secondary molecular disorders determinig drug resistance from a group of proteasome inhibitors...

    Call: OPUS 12 , Panel: NZ5

    Principal investigator: prof. Tadeusz Robak

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  49. The role of neurotrophins and angiogenic cytokines in the pathophysiology of treatment-induced peripheral neuropathy in ...

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: prof. Bogusław Machaliński

    Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Medycyny i Stomatologii

  50. Oncogenic mechanisms of DIS3 mutations

    Call: MAESTRO 8 , Panel: NZ4

    Principal investigator: prof. Andrzej Dziembowski

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie