Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of Fam46C in B cell phisiology

2017/27/B/NZ2/01234

Keywords:

mRNA polyadenylation Immunology B-cells FAM46C multiple myeloma

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_3: Proteomics
  • NZ2_6: Immunogenetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Seweryn Mroczek 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 798 200 PLN

Project start date (Y-m-d): 2018-10-02

Project end date (Y-m-d): 2022-10-01

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do transferu białek (BioRad; Trans-Blot SD Semi-Dry Transfer Cell) z dedykowanym zasilaczem.
  2. Maszyna PCR (The Biometra T3000 lub podobna) (50 000 PLN)
  3. Mastercycler Nexus GSX1.
  4. Komputery z oprogramowaniem (12 000 PLN)
  5. Kołyska laboratoryjna PROBLOT 25XL.
  6. Rozdrabniacz do tkanek (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
    Authors:
    Olga Gewartowska, Goretti Aranaz Novaliches, Paweł S Krawczyk, Seweryn Mroczek, Monika Kusio-Kobiałka, Bartosz Tarkowski, Frantisek Spoutil, Oldrich Benada, Olga Kofroňová, Piotr Szwedziak, Dominik Cysewski, Jakub Gruchota, Marcin Szpila, Aleksander Chlebowski, Radislav Sedlacek, Jan Prochazka, Andrzej Dziembowski
    Academic press:
    Cell Reports (rok: 2021, tom: 35, strony: 109015), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2021.109015 - link to the publication
  2. Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C
    Authors:
    Aleksandra Bilska, Monika Kusio-Kobiałka, Paweł S. Krawczyk, Olga Gewartowska, Bartosz Tarkowski, Kamil Kobyłecki, Dominika Nowis, Jakub Golab, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski, Seweryn Mroczek
    Academic press:
    Nature Communications (rok: 2021, tom: Brak, strony: Brak), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41467-020-15835-3 - link to the publication
  3. Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism
    Authors:
    Zbigniew Warkocki, Vladyslava Liudkovska, Olga Gewartowska, Seweryn Mroczek, Andrzej Dziembowski
    Academic press:
    Philosophical Transactions of the Royal Society B: Biological Sciences (rok: 2018, tom: 373, strony: 45307), Wydawca: rstb.royalsocietypublishing.org
    Status:
    Published
    DOI:
    10.1098/rstb.2018.0162 - link to the publication
  4. TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animala
    Authors:
    Vladyslava Liudkovska, Paweł S Krawczyk, Aleksandra Brouze, Natalia Gumińska, Tomasz Wegierski, Dominik Cysewski, Zuzanna Mackiewicz, Jonathan J Ewbank, Krzysztof Drabikowski, Seweryn Mroczek, Andrzej Dziembowski
    Academic press:
    Science Advances (rok: 2022, tom: 8(46), strony: 45312), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/sciadv.add9468 - link to the publication

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