Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of the human RNA exosome catalytic subunit DIS3 in multiple myeloma pathogenesis and cell physiology.

2011/02/A/NZ1/00001

Keywords:

Myeloma DIS3 RNA exosome tRNA RNA

Descriptors:

  • NZ4_11: Metabolism
  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Dziembowski 

Number of co-investigators in the project: 11

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 990 000 PLN

Project start date (Y-m-d): 2012-05-18

Project end date (Y-m-d): 2017-05-18

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komora laminarna NU440-600E.
  2. Vortex Genie.
  3. Wirówka laboratoryjna Hettich Rotina H380.
  4. Łaźnia wodna.
  5. Mikroskop CKX41 z wyposażeniem.
  6. Pompka wodna (zakup 2013).

Information in the final report

  • Publication in academic press/journals (7)
  1. Cytoplasmic RNA decay pathways - Enzymes and mechanisms
    Authors:
    Łabno A., Tomecki R., Dziembowski A.
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (rok: 2016, tom: 1863, strony: 3125-3147), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2016.09.023 - link to the publication
  2. RNA decay machines: The exosome
    Authors:
    Aleksander Chlebowski, Michał Lubas, Torben Heick Jensen, Andrzej Dziembowski
    Academic press:
    Biochimica et Biophysica Acta (rok: 2013, tom: 1829, strony: 552-560), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2013.01.006. - link to the publication
  3. The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis
    Authors:
    Lubas, M., P. R. Andersen, A. Schein, A. Dziembowski, G. Kudla and T. H. Jensen
    Academic press:
    Cell Reports (rok: 2015, tom: 10, strony: 178-192), Wydawca: Cell press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2014.12.026 - link to the publication
  4. A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans
    Authors:
    Kalisiak K, Kuliński T.M., Tomecki R., Cysewski D., Pietras Z., Chlebowski A., Kowalska K., Dziembowski A.
    Academic press:
    Nucleic Acid Research (rok: 2017, tom: 45 (Issue 4), strony: 2068-2080), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkw862 - link to the publication
  5. DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.
    Authors:
    Szczepińska T, Kalisiak K, Tomecki R, Labno A, Borowski LS, Kulinski TM, Adamska D, Kosinska J, Dziembowski A.
    Academic press:
    Genome Research (rok: 2015, tom: 25, strony: 1622-1633), Wydawca: CSH Press
    Status:
    Published
    DOI:
    10.1101/gr.189597.115 - link to the publication
  6. Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA
    Authors:
    Michal Lubas, Christian K Damgaard, Rafal Tomecki, Dominik Cysewski, Torben Heick Jensen, Andrzej Dziembowski
    Academic press:
    EMBO Journal (rok: 2013, tom: 32, strony: 1793-1965), Wydawca: EMBO Press
    Status:
    Published
    DOI:
    10.1038/emboj.2013.135 - link to the publication
  7. Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target
    Authors:
    Rafal Tomecki,Karolina Drazkowska,Iwo Kucinski, Krystian Stodus, Roman J. Szczesny,Jakub Gruchota, Ewelina P. Owczarek, Katarzyna Kalisiak, and Andrzej Dziembowski
    Academic press:
    Nucleic Acid Research (rok: 2014, tom: 42, strony: 1270-1290), Wydawca: PMC
    Status:
    Published
    DOI:
    10.1093/nar/gkt930 - link to the publication

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