Projects funded by the NCN

Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza, Wydział Chemii

Can extracts from Epilobium sp. inhibit proliferation of prostate cell LNCaP by influencing the activity of histone acet...

Call: SONATA 1 , Panel: NZ4

Principal investigator: dr hab. Anna Kiss

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr Tomasz Prajsnar

Uniwersytet Jagielloński, Wydział Biologii

Functional and structural analysis of anticancer drugs as protein biosynthesis inhibitors

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Witold Szaflarski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

Call: OPUS 25 , Panel: ST4

Principal investigator: prof. Arkadiusz Chworoś

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Compounds modulating function of telomeric proteins TRF1 and TRF2

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Maciej Bagiński

Politechnika Gdańska, Wydział Chemiczny

Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr Anna Zawadzka

Uniwersytet Warszawski, Wydział Chemii

Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr hab. Magdalena Stobiecka

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Krzysztof Domka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Understanding the contribution of immunoproteasome activation to the neuropathic pain development.

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr Natalia Małek-Chudzik

Politechnika Wrocławska

Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Emilia Sługocka

Uniwersytet Jagielloński, Collegium Medicum

Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marika Frańczak

Gdański Uniwersytet Medyczny, Wydział Lekarski

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Potok

Uniwersytet Wrocławski, Wydział Chemii

Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Alicja Braczko

Gdański Uniwersytet Medyczny, Wydział Lekarski

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: dr Dorota Suszczyk

Uniwersytet Medyczny w Lublinie

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr Edyta Dyguda-Kazimierowicz

Politechnika Wrocławska

Efektywność nowatorskiej terapii inhibitorami JAK u pacjentów z reumatoidalnym zapaleniem stawów w odniesieniu do profil...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Sylwia Biały

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Construction of Candida famata flavinogenic yeast strains with improved ability to produce riboflavin in medium with lig...

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Dominik Wojdyła

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Development of novel anti-cancer immunotherapy against mesothelioma comprising of oncolytic adenovirus vectors armed wit...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Łukasz Kuryk

Narodowy Instytut Zdrowia Publicznego PZH - Państwowy Instytut Badawczy

Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

Call: SONATA 18 , Panel: NZ6

Principal investigator: dr Wioletta Rut

Politechnika Wrocławska

Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

Call: POLONEZ BIS 3 , Panel: NZ7

Principal investigator: dr hab. Aneta Radziwon-Balicka

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Identification of key structural elements of immunomodulatory proteins - inhibitors of antigenic peptide transporter TAP...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Natalia Karska

Uniwersytet Gdański, Wydział Chemii

The role of diet in the development of autoimmune diseases - new interleukin 15 inhibitors among dietary polyphenols and...

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Barbara Żyżyńska-Granica

Warszawski Uniwersytet Medyczny

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr Karolina Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Histone demethylase inhibitors as chemosensitivity modulators in the treatment of head and neck squamous cell carcinoma

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Dawid Dorna

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Katarzyna Dziubek

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

Pharmacogenomics of SGLT2 inhibitors - investigating the role of empagliflozin in epigenetic modification of non-coding ...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Anna Nowak

Warszawski Uniwersytet Medyczny

The effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on changes in selected epigenetic mechan...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Agnieszka Woźniak

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Two-component preparations in the treatment of infections caused by pathogenic microorganisms

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Szałapata

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Molecular determinants of input specificity in plasticity phenomena at GABAergic synapses in the hippocampus

Call: OPUS 22 , Panel: NZ4

Principal investigator: prof. Jerzy Mozrzymas

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

SELECTIVE REGULATION OF RAB GTPASES BY TARGETING PROTEIN-PROTEIN INTERACTIONS BETWEEN RABS AND REGULATORY PROTEINS

Call: PRELUDIUM BIS 3 , Panel: ST4

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Combinatorial targeting of non-genetic sources of cell-to-cell heterogeneity to overcome fractional killing of cancer ce...

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Jarosław Walczak

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

Radiosensitization by the combined use of modified nucleosides and inhibitors of DNA repair to improve the efficacy of r...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Magdalena Zdrowowicz-Żamojć

Uniwersytet Gdański, Wydział Chemii

Structure-guided design of histone demethylase inhibitors for cancer therapy.

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Piotr Małecki

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Ireneusz Majsterek

Uniwersytet Medyczny w Łodzi

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Florczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Function of DNA methylation and CNV-type polymorphisms of genes encoding metalloproteinase and their tissue inhibitors i...

Call: OPUS 2 , Panel: NZ5

Principal investigator: dr Edyta Majorczyk

Politechnika Opolska, Wydział Wychowania Fizycznego i Fizjoterapii

Lipidic liquid-crystalline nanomaterials for reconstitution and physico-chemical studies of membrane proteins

Call: OPUS 22 , Panel: ST4

Principal investigator: prof. Renata Bilewicz

Uniwersytet Warszawski, Wydział Chemii

Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Carlo Vascotto

Instytut Hematologii i Transfuzjologii

Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

The structures, biochemistry, physiology, and evolution of bacterial α2-macroglobulins from the human periodontopathogen...

Call: SONATA BIS 11 , Panel: NZ1

Principal investigator: dr Mirosław Książek

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Mikołaj Czajkowski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Research on the influence of medicines of the angiotensin-converting enzyme inhibitors (ACEI) group on the choroidal and...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Jowita Zwolska

Uniwersytet Przyrodniczy w Lublinie, Wydział Medycyny Weterynaryjnej

Heterocyclization of benzenoid ansamycins core as useful strategy for designing anticancer agents

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Natalia Skrzypczak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Novel combination therapies of pulmonary arterial hypertension targeting blockade of peripheral cannabinoid CB1 receptor...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Barbara Malinowska

Uniwersytet Medyczny w Białymstoku

Pharmacological potential of mistletoe (Viscum album L.) in the prevention of central nervous system disorders.

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Szurpnicka

Narodowy Instytut Leków