Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Thiol oxidoreductases of Helicobacter spp. - biochemical and structural characterization of the H. hepaticus Dsb system and an attempt to develop inhibitors of H. pylori oxidative protein folding

2018/29/B/NZ1/00140

Keywords:

disulfide bonds new therapies inhibitors Helicobacter spp.

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dariusz Bartosik 

Number of co-investigators in the project: 9

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 753 440 PLN

Project start date (Y-m-d): 2019-06-03

Project end date (Y-m-d): 2023-06-02

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Generowanie mostków disiarczkowych w białkach – różnorodność strukturalna i funkcjonalna białek DsbA
    Authors:
    Anna Marta Banaś, Anna Petrykowska, Elżbieta Katarzyna Jagusztyn-Krynicka
    Academic press:
    Postępy Mikrobiologii – Advancements in Microbiology (rok: 2020, tom: 59, strony: 345-355), Wydawca: PTM
    Status:
    Published
    DOI:
    10.21307/PM-2020.59.4.26 - link to the publication
  2. Exploring the inhibitory potential of in silico-designed small peptides on Helicobacter pylori Hp0231 (DsbK), a periplasmic oxidoreductase involved in disulfide bond formation
    Authors:
    Paula Roszczenko-Jasińska, Artur Giełdoń, Dominika Mazur, Marta Spodzieja, Maciej Plichta, Cezary Czaplewski, Wojciech Bal, Elzbieta K. Jagusztyn-Krynicka, Dariusz Bartosik
    Academic press:
    Frontiers in Molecular Sciences (rok: 2024, tom: 10, strony: 1335704), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fmolb.2023.1335704 - link to the publication
  3. Helicobacter pylori treatment in the post-antibiotics era-searching for new drug targets.
    Authors:
    Roszczenko-Jasińska P, Wojtyś MI, Jagusztyn-Krynicka EK
    Academic press:
    Appl Microbiol Biotechnol. (rok: 2020, tom: 104, strony: 9891-9905), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00253-020-10945- - link to the publication

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