Projects funded by the NCN
De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhibitors
2018/31/B/ST5/02631
Keywords:
peptides inhibitors computer-aided design beta-amino acids
Descriptors:
- ST5_11:
- NZ1_4:
- ST5_22:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Politechnika Wrocławska, Wydział Chemiczny
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 9
Call: OPUS 16 - announced on 2018-09-14
Amount awarded: 2 364 600 PLN
Project start date (Y-m-d): 2019-07-15
Project end date (Y-m-d): 2023-07-14
Project duration:: 36 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Book publications / chapters in book publications (1)
- Scalable Synthesis of All Stereoisomers of 2-Aminocyclopentanecarboxylic Acid─ A Toolbox for Peptide Foldamer ChemistryAuthors:Vitaly Kovalenko, Ewa Rudzinska-Szostak, Katarzyna Slepokura, Łukasz BerlickiAcademic press:The Journal of Organic Chemistry (rok: 2024, tom: 89, strony: 4760–4767), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acs.joc.3c02991 - link to the publication
- Miniproteins in medicinal chemistryAuthors:Agnieszka Ciesiołkiewicz, Juan Lizandra Perez, Łukasz BerlickiAcademic press:Bioorganic & Medicinal Chemistry Letters (rok: 2022, tom: 71, strony: 128806), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bmcl.2022.128806 - link to the publication
- Miniprotein engineering for inhibition of PD-1/PD-L1 interactionAuthors:Agnieszka Ciesiołkiewicz, Juan Lizandra Perez, Lukasz Skalniak, Paweł Noceń, Łukasz BerlickiAcademic press:Protein Science (rok: 2024, tom: 33, strony: e5106), Wydawca: The Protein Society/WileyStatus:PublishedDOI:10.1002/pro.5106 - link to the publication
- Tailoring peptides and peptidomimetics for targeting proteinprotein interactionsAuthors:Łukasz BerlickiBook:Peptide and Peptidomimetic Therapeutics From Bench to Bedside (rok: 2022, tom: 1, strony: 57-71), Wydawca: Elsevier - Academic PressStatus:Published